A measure concerning family management of children with chronic conditions is needed to identify the relationship between family management and family and child outcomes. This study aimed to use cognitive interviews to apply the Family Management Measure (FaMM) to Taiwanese families with children who have chronic conditions. When using a measure from other cultures, cultural adaption should be considered besides the language translation from foreign language to first language. Conducting a cognitive interviewing study is an efficient way to examine semantic equivalence and culture applicability of a measure. Our study involved cognitive interviews with 28 caregivers to develop the Family Management Measure Taiwanese Version (FaMM-TW). Through cognitive interviews, three types of problems in the initial translation version were identified. Four items were modified due to semantic problems. One language expression and three items with colloquial and idiomatic problems were rephrased. One item was revised for cultural and experiential reasons. Each modified item in the translated version was culturally adapted, but the key concepts in the original measure were still reserved. This paper shed light on the application of cognitive interviews to cross-culturally adapt the FaMM for Taiwanese participants with different family types.