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Protibakterijske spojine z multiplim delovanjem = Antibacterial compounds with multiple mode of actionDurcik, Martina ; Ilaš, JanezOdkritje antibiotikov, ki jih včasih imenujemo kar »čudežna zdravila«, je močno pripomoglo k manjši smrtnosti in pozitivno vplivalo na medicinski napredek. V odgovor na rabo antibiotikov so bakterije ... razvile različne mehanizme odpornosti in tako naraščajoča bakterijska odpornost proti znanim protibakterijskim učinkovinam v 21. stoletju predstavlja globalni problem. Bakterije lahko razvijejo odpornost na vsa znana protimikrobna zdravila in kljub velikemu številu raziskav ter veliko spojinam v kliničnih preskušanjih je potreba po odkrivanju novih učinkovin in terapevtskih pristopov vedno večja. Spojine, ki zavirajo več bakterijskih tarč, multitarčni ligandi, so ena od strategij boja z bakterijsko odpornostjo. Simultano zaviranje več tarč v bakteriji namreč pomeni, da bi mutacije za pridobitev odpornosti morale poteči na več mestih hkrati, kar je manj verjetno. Četudi spojine z multiplim delovanjem ne predstavljajo absolutne rešitve, pa lahko znatno pripomorejo k upočasnitvi pojava odpornih sevov.Source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 73, št. 3, jul. 2022, str. 241-251)Type of material - article, component part ; adult, seriousPublish date - 2022Language - slovenianCOBISS.SI-ID - 115506179
Author
Durcik, Martina |
Ilaš, Janez
Topics
Bakterijska rezistenca |
bakterijska odpornost |
konjugati |
multipli zaviralci |
protibakterijske spojine
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source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 73, št. 3, jul. 2022, str. 241-251)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Durcik, Martina | 50490 |
Ilaš, Janez | 24400 |
Source: Personal bibliographies
and: SICRIS
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