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Oxidative stress, acetylcholine and excitotoxicity
Dettbarn, Wolf D ...
This chapter gives an overview based on experiments investigating the hypothesis that a causal relationship exists between the generation of reactive oxygen species (ROS), lipid peroxidation and ...excitotoxicity. Reactiveoxygen species are suggested to contribute to muscle fiber and neuronal damage associated with cholinergic excitotoxicity. Most of the evidence is based on indirect techniques such as determination od products of lipid peroxidation. The results of expeiments using direct determination of reactive oxygen species with spin trapping agents are difficult to interpret due to lack of identification and quantification of the reactive oxygen species involved. Spin trapping agents have numerous pharmacological actions unrelated to trapping of ROS, and these should be considered when explaining the protection afforded by spin trapping agents.
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