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Atorvastatin therapy may reduce the incidence of sudden cardiac death in patients with advanced chronic heart failureVrtovec, Bojan, 1972- ...Background: In retrospective studies, statin therapy has been related to decreased incidence of sudden cardiac death (SCD) in heart failure. We sought to prospectively investigate a relation between ... atorvastatin therapy and SCD in patients with advanced chronic heart failure. Methods and results: We enrolled 110 patients with heart failure with a left ventricular ejection fraction less than 30% and cholesterol level greater than 150 mg/dL. Fifty-five patients were randomized to atorvastatin (10 mg/day) (statin group); the remaining 55 patients received no statins (controls). Patients were followed for 1 year. At baseline, the two groups did not differ in age, sex, left ventricular ejection fraction, cholesterol, B-type natriuretic peptide, heart rate variability, or QT variability. During follow-up, 29 patients died (26%) and 2 patients (2%) underwent heart transplantation. Of the 29 deaths, 13 were attributed to pump failure, 15 were attributed to SCD, and 1 was attributed to noncardiac causes. All-cause mortality was lower in the statin group (9/55, 16%) than in controls (20/55, 36%) (P = .017). The same was true of the SCD rate (3/55 š5%đ vs. 12/55 š22%đ, P = .012), but not of the pump failure (5/55 š9%đ vs. 8/55 š15%đ, P = .38). SCD-free survival was2.3-times higher in the statin group than in controls (P = .01). Conclusion: Atorvastatin therapy seems to be associated with decreased incidence of SCD in patients with advanced chronic heart failure. Larger studies are ongoing to confirm this hypothesis.Source: Journal of cardiac failure. - ISSN 1071-9164 (Letn. 14, št. 2, 2008, str. 140-144)Type of material - article, component partPublish date - 2008Language - englishCOBISS.SI-ID - 24072409
Author
Vrtovec, Bojan, 1972- |
Okrajšek, Renata |
Goličnik, Alenka |
Ferjan, Mateja |
Starc, Vito |
Schlegel, Todd T. |
Radovančević, Branislav
Topics
Heart Failure, Congestive |
Death, Sudden, Cardiac |
Prevention And Control |
Antilipemic Agents |
Hypercholesterolemia |
Natriuretic Hormone |
Cardiac Output, Low |
Retrospective Studies |
Lipolitiki |
Natriuretični hormon |
Srce, odpoved kongestivna |
Hiperholesterolemija |
Smrt nenadna, srčna |
Retrospektivne študije |
Srce, iztisni volumen nizki
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Vrtovec, Bojan, 1972- | 18826 |
Okrajšek, Renata | 32517 |
Goličnik, Alenka | 51514 |
Ferjan, Mateja | ![]() |
Starc, Vito | 04341 |
Schlegel, Todd T. | ![]() |
Radovančević, Branislav | ![]() |
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