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Duodenocutaneous fistulainrats asa modelfor "wound healing-therapy" inulcer healing : the effect of pentadecapeptide BPC157, L-nitro-arginine methylester and L-arginine
Škorjanec, Sandra, zdravnica ...
While very rarely reported, duodenocutanenous fistula research might alter the duodenal ulcer disease background andtherapy. Our research focused on rat duodenocutaneous fistulas, therapy, stable ...gastric pentadecapeptide BPC 157, ananti-ulcer peptide that healed other fistulas, nitric oxide synthase-substrate L-arginine, and nitric oxide synthase-inhibitor L-nitro-arginine methyl ester (L-NAME). The hypothesis was, duodenal ulcer-healing, like the skin ulcer, usingthe successful BPC 157, with nitric oxide-system involvement, the "wound healing-therapy", to heal the duodenal ulcer,the fistula-model that recently highlighted gastric and skin ulcer healing. Pressure in the lower esophageal and pyloricsphincters was simultaneously assessed. Duodenocutaneous fistula-rats received BPC 157 (10 microg/kg or 10 ng/kg,intraperitoneally or perorally (in drinking water)), L-NAME (5 mg/kg intraperitoneally), L-arginine (100 mg/kgintraperitoneally) alone and/or together, throughout 21 days. Duodenocutaneous fistula-rats maintained persistentdefects, continuous fistula leakage, sphincter failure, mortality rate at 40% until the 4thday, all fully counteracted in allBPC 157-rats. The BPC 157-rats experienced rapidly improved complete presentation (maximal volume instilledalready at 7thday). L-NAME further aggravated the duodenocutaneous fistula-course (mortality at 70% until the 4thday);L-arginine was beneficial (no mortality; however, maximal volume instilled not before 21th day). L-NAME-worseningwas counteracted to the control level with the L-arginine effect, and vice versa, while BPC 157 annulled the L-NAMEeffects (L-NAME + L-arginine; L-NAME + BPC157; L-NAME + L-arginine + BPC157 brought below the level of thecontrol). It is likely that duodenocutaneous fistulas, duodenal/skin defect simultaneous healing, reinstated sphincterfunction, are a new nitric oxide-system related phenomenon. In conclusion, resolving the duodenocutanenous fistulas-healing, nitric oxide-system involvement, should illustrate further wound healing therapy to heal duodenal ulcers.
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