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Mutagenicity and DNA damage of bisphenol A and its structural analogs = Mutagenost in poškodbe DNA povzročene z bisfenolom A in njegovimi strukturnimi analogiFic, Anja ...An environmental estrogen, bisphenol A (BPA), and its analogs are widespread in our living environment. Because their production and use are increasing, exposure of humans to bisphenols is becoming a ... significant issue. We evaluatedthe mutagenic and genotoxic potential of eight BPA structural analogs(BPF, BPAF, BPZ, BPS, DMBPA, DMBPS, BP-1 and BP-2), with Ames and cometassays, respectively. None of the tested bisphenols (0.004, 0.02, 0.1 and0.5 mg/plate) showed a mutagenic effect in Salmonella typhimurium strains TA98 and TA100, in either the presence or absence of external S9-mediated metabolic activation (Aroclor 1254-induced male rat liver). The potential genotoxicity of bisphenols was determined in the human hepatoma cell line (HepG2) at non-cytotoxic concentrations (0.1 - 10 ŽM) after 4 and 24 h exposure. In the comet assay, BPA and its analog BPS induced significant DNA damage only after 24 h exposure, while analogs DMBPS, BP-1 and BP-2 induced transient increase in DNA strand breaks observed only after 4 h exposure. BPF,BPAF, BPZ and DMBPA did not induce DNA damage in the applied experimental conditions.Source: Arhiv za higijenu rada i toksikologiju = Archives of industrial hygiene and toxicology. - ISSN 0004-1254 (Vol. 64, no. 2, 2013, str. 189-200)Type of material - article, component partPublish date - 2013Language - englishCOBISS.SI-ID - 3437937
Author
Fic, Anja |
Žegura, Bojana |
Sollner Dolenc, Marija |
Filipič, Metka, 1954- |
Peterlin-Mašič, Lucija
Topics
bisfenol A |
bisfenoli |
mutagenost |
genotoksičnost |
kometni test |
Amesov test
source: Arhiv za higijenu rada i toksikologiju = Archives of industrial hygiene and toxicology. - ISSN 0004-1254 (Vol. 64, no. 2, 2013, str. 189-200)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Fic, Anja | 33295 |
Žegura, Bojana | 20767 |
Sollner Dolenc, Marija | 08519 |
Filipič, Metka, 1954- | 09892 |
Peterlin-Mašič, Lucija | 19317 |
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