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Razvoj in validacija LC-MS/MS metode za sočasno določanje fentanila in midazolama v plazemskih vzorcih : [Krkine nagrade]Rožman, Eva ; Vrbek, SanjaPri huje bolnih otrocih se za sedacijo lahko uporablja kombinacija fentanila in midazolama. Pri otrocih je za analize velikokrat na voljo le majhen volumen plazme, zato predstavljajo veliko prednost ... analizne metode, ki omogočajo sočasno določevanje več učinkovin v plazmi. Zaradi potrebe po nizki meji kvantifikacije in selektivnosti pri določanju analitov v plazemskih vzorcih, smo se odločili za uporabo tekočinske kromatografije sklopljene z masno spektrometrijo (LC-MS/MS). Analizna metoda, ki smo jo razvili in validirali za sočasno določanje fentanila in midazolama, je za fentanil linearna v območju 0,04-40 [micro]g/L in za midazolam v območju 2-2000 [micro]g/L.Metoda pokriva plazemske koncentracije fentanila in midazolama, ki so predvidene v primeru sedacije in analgezije pri otrocih. Metoda izkazuje tudi ustrezno ponovljivost, točnost in uspešnost ekstrakcije tekoče-tekoče za oba analita. Meja kvantifikacije za midazolam znaša [micro]g/L, za fentanil pa 0,04 [micro]g/l. Pri fentanilu, ki je še zlasti problematičen zaradi nizkih plazemskih koncentracij, je meja kvantifikacije primerljiva z že objavljenimi analiznimi metodami za fentanil, a veliko nižja kot pri metodah, ki sočasno analizirajo fentanil in midazolam. Analizno metoda smo uspešno uporabiti v raziskavi, kjer so otroci s hudim bronhiolitisom prejemali fentanil in midazolam v obliki kontinuirane intravenske infuzije.Type of material - research projectPublication and manufacture - Ljubljana : [E. Rožman] : [S. Vrbek], 2012Language - slovenianCOBISS.SI-ID - 3672689
Author
Rožman, Eva |
Vrbek, Sanja
Other authors
Kerec Kos, Mojca |
Roškar, Robert, 1975-
Topics
fentanil |
midazolam |
farmakokinetika |
tekočinska kromatografija |
masna spektrometrija
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Rožman, Eva | |
Vrbek, Sanja | 38165 |
Kerec Kos, Mojca | 20370 |
Roškar, Robert, 1975- | 23549 |
Source: Personal bibliographies
and: SICRIS
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