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Non-immunoglobulin scaffolds : a focus on their targetsŠkrlec, Katja, farmacevtka ; Štrukelj, Borut ; Berlec, AlešNon-immunoglobulin (non-Ig) scaffolds are, in contrast to antibodies, small single-domain proteins that require no post-translational modification, often lack disulfide bonds, and can undergo ... straightforward multimerization. Among the 20 different types of non-Ig scaffolds, Adhirons, Alphabodies, Centyrins, Pronectins, Repebodies, Affimers, and Obodies have been introduced in the past4 years. 102 proteins have been specifically targeted by 139 different non-Ig scaffold binders. The most frequent application of non-Ig scaffolds is in the treatment and diagnosis of cancer and inflammatory diseases, and 10 non-Ig scaffolds have already been tested in clinical trials. Recently, non-Igscaffolds have often been used in research as structure determination chaperones, for intracellular monitoring of post-translational modifications, and as antibody alternatives for microscopy, flow cytometry, and Western blotting.Source: Trends in biotechnology. - ISSN 0167-7799 (Vol. 33, iss. 7, 2015, str. 408-418)Type of material - article, component partPublish date - 2015Language - englishCOBISS.SI-ID - 3851377
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Škrlec, Katja, farmacevtka | 36337 |
Štrukelj, Borut | 07849 |
Berlec, Aleš | 24257 |
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