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Antibacterial and beta-lactamase inhibitory activity of monocyclic beta-lactams [Elektronski vir]Decuyper, Lena ...Due to the widespread emergence of resistant bacterial strains, an urgent need for the development of new antibacterial agents with novel modes of action has emerged. The discovery of naturally ... occurring monocyclic beta-lactams in the late 1970s, mainly active against aerobic Gram-negative bacteria, has introduced a new approach in the design and development of novel antibacterial beta-lactam agents. The main goal was the derivatization of the azetidin-2-one core in order to improve their antibacterial potency, broaden their spectrum of activity, and enhance their beta-lactamase stability. In that respect, our review covers the updates in the field of monocyclic beta-lactam antibiotics during the last three decades, taking into account an extensive collection of references. An overview of the relationships between the structural features of these monocyclic beta-lactams, classified according to their N-substituent, and the associated antibacterial or beta-lactamase inhibitory activities is provided. The different paragraphs disclose a number of well-established classes of compounds, such as monobactams, monosulfactams, monocarbams, monophosphams, nocardicins, as well as other known representative classes. Moreover, this review draws attention to some less common but, nevertheless, possibly important types of monocyclic beta-lactams and concludes by highlighting the recent developments on siderophore-conjugated classes of monocyclic beta-lactams.Source: Medicinal research reviews. - ISSN 1098-1128 (Vol. 38, iss. 2, 2018, Str. 426-503)Type of material - e-articlePublish date - 2018Language - englishCOBISS.SI-ID - 4363633
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Decuyper, Lena | |
Jukič, Marko | 32587 |
Sosič, Izidor | 30816 |
Žula, Aleš | 33054 |
D'hooghe, Matthias | |
Gobec, Stanislav, 1970- | 15284 |
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