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Interakcije kanabinoidov z zdraviliPeterlin-Mašič, LucijaIstočasna izpostavljenost THC (delta-9-tetrahidrokanabinolu) in/ali CBD (kanabidiolu) z drugimi učinkovinami lahko vodi do interakcij, ki imajo vpliv na učinkovitost in varnost zdravljenja. ... Kanabinoidi se praviloma uporabljajo skupaj z drugimi učinkovinami, zato je razumevanje klinično pomembnih interakcij relevantno. Obstaja potencial za klinično pomembno zvišanje koncentracij THC pri posameznikih, ki imajo zmanjšano funkcijo encimov CYP2C9 in/ali CYP3A4 ter za klinično pomembno zvišanje koncentracij CBD pri posameznikih z zmanjšano funkcijo encimov CYP2C19 in/ali CYP3A4. Po eni strani so tveganja za interakcije med kanabinoidi in učinkovinami večja pri starostnikih, po drugi strani pa pri učinkovinah z ozkim terapevtskim oknom (npr. varfarin) ter induktorjih in zaviralcih metaboličnih encimov. Prav tako vplivata na tveganje za interakcije med kanabinoidi in učinkovinami način aplikacije kanabinoidov ter odmerek. V realnosti so interakcije med kanabinoidi in učinkovinami kompleksne in obstaja še veliko praznin v njihovem razumevanju in klinični pomembnosti. Trenutno lahko podamo le nespecifična priporočila o previdnosti, bolj specifičnih priporočil o klinično pomembnih interakcijah trenutno ni mogoče podati na osnovi podatkov, ki so na voljo.Source: Uporaba kanabinoidov : strokovno izpopolnjevanje s področja farmacije, [Ljubljana, 11., 12. in 18. junij 2019] (Str. 57-64)Type of material - conference contributionPublish date - 2019Language - slovenianCOBISS.SI-ID - 4731249
Author
Peterlin-Mašič, Lucija
Topics
Zdravila |
kanabinoidi |
interakcije učinkovin |
antiepileptiki |
varfarin |
metabolizem CBD
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Peterlin-Mašič, Lucija | 19317 |
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