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Vloga fibroblastnega rastnega faktorja 23 (FGF23) v homeostazi fosfata = The role of fibroblast growth factor 23 (FGF23) in phosphate homeostasis
Gorenjak, Maksimiljan
FGF23 je ključni modulator homeostaze fosfata. S svojim specifičnim delovanjem na celice ledvičnih tubulov pospešuje izločanje fosfata z urinom. Hkrati zavira nastanek aktivne oblike vitamina D in ...pospešuje njeno presnovo v manj aktivni metabolit. Vse omenjene aktivnosti vodijo v znižanje plazemske koncentracije fosfata. FGF23 izločajo osteociti in osteoblasti kosti kot odgovor na povišano koncentracijo fosfata ali aktivne oblike vitamina D v krvi. Pri KLB predstavlja FGF23 kompenzacijski mehanizem, ki znižuje serumsko koncentracijo fosfata. Z napredovanjem bolezni in izgubo veznega elementa proteina Klotho, ta mehanizem popušča. Merjenje FGF23 v krvi predstavlja pomembno diagnostično sredstvo za laboratorijsko diagnostiko bolnikov z različnimi motnjami v homeostazi fosfata. Uporaba občutljive tehnologije določanja FGF23 omogoča nove informacije in vpogled v regulacijo metabolizma kosti in mineralov.
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