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Analytical performance evaluation of biochemical parameters of a public hospital laboratory = Avaliação do desempenho analítico de parâmetros bioquímicos do laboratório de análises clínicas de um hospital públicoRahn, Barbara ...Introduction: Every process is subject to variation in the results of repeated analyses, that is why quality control was conceived to measure and evaluate this variation. In addition to the daily ... analysis of control results, a long-term assessment should evaluate the analytical performance of each method for inaccuracy and imprecision according to quality specifications (QS). Objective: This study aimed to evaluate the analytical performance of biochemical parameters of the Clinical Analysis Laboratory (CAL) of a Brazilian university hospital, according to the QS based on biological variation and comparing to an international laboratory. Material and method: Twenty-six biochemical parameters were analyzed. The QS for coefficient of variation (CV), bias and total error (TE) were calculated according to the intraindividual (CVbi) and interindividual (CVbg) biological variation of the analytes described in the literature. The sigma metric (σ) was also calculated based on desirable TE and Clinical Laboratory Improvement Amendments (CLIA). Results: Calcium and sodium analytes were out of the QS for all criteria used (CV, bias and TE) in both laboratories. CAL showed 19% of analytes (albumin, calcium, magnesium, total protein, and sodium) outside the QS in all criteria, and the international laboratory 8%. Using the sigma metric, the analytical performance of CAL was also inferior regarding to the comparative laboratory: 54% of analytes with σ < 3 versus 38%. Conclusion: The sigma metric was more rigorous in the evaluation of the analytical performance of biochemical parameters compared to the QS based on biological variation. The non-achievement of quality goals was not laboratory-specific.Source: Jornal Brasileiro de Patologia e Medicina Laboratorial. - ISSN 1678-4774 (Vol. 57, no. 1, 2021, str. 1-10)Type of material - e-articlePublish date - 2021Language - english, portugueseCOBISS.SI-ID - 93586435
Author
Rahn, Barbara |
Jerin, Aleš |
Skitek, Milan |
Snoj, Nada, 1966- |
Martinello, Flávia
Topics
Biometrija |
Laboratorijska medicina
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Rahn, Barbara | |
Jerin, Aleš | 17160 |
Skitek, Milan | 11331 |
Snoj, Nada, 1966- | 15984 |
Martinello, Flávia |
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