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Mixture design of theophylline retard formulationKristl, Albin ...Three different cellulose derivatives (hydroxypropyl cellulose (HPC), hydroxypropyl methyl cellulose (HPMC) and microcrystalline cellulose (MC) wereused to prepare 10% of thephylline with the aid of ... wet granulation. The retardation effevt of different compositions of these cellulose derivatives was investigated. Using mixture design, the formulations with the best retardation properties were selected. On the basis of these results, tablets with different compositions containing 60% (300 mg) of thephylline were prepared. The simulation was performed on a personal computer with the implemented digital simulation language SIMCOS to predict steady-state plasma levels. It was established that formulation C, composed of 34,6% of MC, 4,7% of HPMC, 0,7% of HPC and 60% of thephylline in vivo the same retardation effect as commercially available theophylline tablets.Source: International journal of pharmaceutics. - ISSN 0378-5173 (Vol. 100, 1993, str. 33-40)Type of material - article, component part ; adult, seriousPublish date - 1993Language - englishCOBISS.SI-ID - 96881
Author
Kristl, Albin |
Vojnović, Dario |
Karba, Rihard |
Mrhar, Aleš |
Rubessa, Fulvio |
Zupančič, Borut
Topics
derivati |
celuloza |
simulacija |
metode |
teofilin
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Kristl, Albin | 11122 |
Karba, Rihard | 01952 |
Mrhar, Aleš | 06086 |
Source: Personal bibliographies
and: SICRIS
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