Faculty of Pharmacy, Lj. (FFALJ)
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Primerjava proučevanja prehoda nekaterih učinkovin skozi monosloj Caco-2 celic in podganji jejunum in vitro = Comparison of transport properties for different substances through CACO-2 cell monolayer and rat jejunum in vitro : diplomska nalogaPehan, SandraV diplomskem delu smo z uporabo modificiranih Sweetana-Grass difuzijskih komorprouèevali prehod izbranih uèinkovin skozi izoliran podganji jejunum in monosloj Caco-2 celic in vitro. Rezultate ... navideznih permeabilnostnih koeficientov (Papp) smo statistièno vrednotili in iz (ne)signifikantnosti razlik med M-S (AP-BL) in S-M (BL-AP) Papp vrednosti za posamezno uèinkovino ugotavljali, na kaksen naèin se uèinkovina prenasa skozi tkivo oz. celice ter ugotavljali razlike v prehodu med obema in vitro modeloma.V nadaljevanju smo uèinkovine uvrstili v BCS sistem glede na fabs, doloèen pri èloveku, in le-tega razsirili z uvedbo razreda srednje permeabilnosti. V razred V smo takouvrstili timolol, ranitidin, cimetidin, atenolol in guanabenz, v razred VIpa smo uvrstili etopozid. Dobro korelacijo med M-S Papp vrednostmi in frakcijo absorbirane uèinkovine (fabs) smo ugotovili za izoliran podganji jejunum, medtem ko korelacije med AP-BL Papp in fabs za Caco-2 celice nismo mogli doloèiti. Razlog za to so najverjetneje razlike v ekspresiji prenasalcevin razlike v absorpcijski povrsini med Caco-2 celicami in èloveskimjejunumom. Za nobenega od uporabljenih in vitro modelov (podganji jejunum, monosloj Caco-2 celic) nismo uspeli doloèiti korelacije med M-S (AP-BL) Papp vrednostmi in logP, kar lahko pojasnimo z dejstvom, da absorpcijauèinkovin ni odvisna le od njihove lipofilnosti, temveè tudi od drugih fizikalno-kemijskih lastnosti uèinkovine in fizioloskih lastnosti èrevesne bariere. Kljub temu, da smo z linearno regresijo doloèili visok Pearsonov koeficient (R2=0,8197) pri primerjavi M-S Papp in AP-BL Papp vrednosti, zaradi grupiranosti podatkov ne moremo trditi, da je tako doloèena korelacija resnièna. Glede na rezultate, pridobljene v tem diplomskem delu lahko sklepamo, da je podganji jejunum primeren in vitro model za napovedovanje fabs pri èloveku, medtem ko za Caco-2 celice tega nismo uspeli potrditi.Type of material - undergraduate thesisPublication and manufacture - Ljubljana : [Pehan, S.], 2006Language - slovenianCOBISS.SI-ID - 1929073
Author
Pehan, Sandra
Other authors
Kristl, Albin |
Šturm, Katja, farmacevtka
Topics
podganji jejunum |
Caco-2 celične kulture |
biofarmacija |
absorpcija učinkovin
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Knjižnica dp 0000000543 Pehan Sandra Primerjava IN: 0008937 Knjižnica dp 543 Pehan Sandra Primerjava IN: 0008937 |
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Database name | Field | Year |
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Pehan, Sandra | ![]() |
Kristl, Albin | 11122 |
Šturm, Katja, farmacevtka | 25492 |
Source: Personal bibliographies
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