Faculty of Pharmacy, Lj. (FFALJ)
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Fiksna kombinacija perindoprila i amlodipina - optimalno liječenje arterijske hipertenzije i koronarne bolesti srca = Fixed combination perindopril-amlodipine - optimised treatment in hypertension and coronary artery diseaseLjevar, Veronika ; Knavs Vrhunec, Polona ; Barbič-Žagar, BredaArterijska hipertenzija (AH) predstavlja najveÊi pojedinaËni Ëimbenik rizika koji doprinosi globalnoj smrtnosti. Usprkos stalnom poboljŽanju lijeËenja, samo jedna treÊina lijeËenih bolesnika postiæe ... ciljane vrijednosti arterijskogtlaka (AT). Novija kliniËka istraæivanja navode da pristup koriŽtenja monoterapije za kontrolu AH vjerojatno neÊe biti uspjeŽan kod mnogih bolesnika. Stoga prednost ima kombinirana terapija, temeljem Ëinjenice da AH doprinose viŽestruki Ëimbenici, a postizanje kontrole AT sa samo jednim lijekom koje djeluje preko jednog mehanizma vjerojatno neÊe biti dostatno. Kombiniranjem lijekova u odgovarajučoj dozi smanjuje se doza pojedinačnih komponenti i učestalost nuspojava te se poboljšava suradljivost bolesnika. Temeljem dokaza iz studije Anglo-Scandinavian Cardiac Outcomes Trial Blood Pressure-Lowering Arm (ASCOT-BPLA) kombinacija inhibitora angiotenzin konvertirajuÊeg enzima (ACE) i blokatora kalcijevih kanala (CCB) predstavlja lijeËenje izbora kod AH. Kombinacija perindoprila i amlodipina jedini je oblik liječenja kombinacijom ACE inhibitora i CCB koje je dokazalo da zadovoljava primarni cilj antihipertenzivne terapije, tj. ukupno smanjenje pobola i smrti povezanog s AH. Krka je trenutno jedina generička tvrtka koja nudi fiksnu kombinaciju perindoprila i amlodipina i tako omogučava učinkovito lijeËenje prilago- Ženo pojedinaËnim potrebama bolesnika i liječnika.Source: Cardiologia Croatica. - ISSN 1848-543X (Vol. 7, no. 9-10, 2012, str. 256-259)Type of material - article, component partPublish date - 2012Language - croatian, englishCOBISS.SI-ID - 3417969
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Ljevar, Veronika | ![]() |
Knavs Vrhunec, Polona | ![]() |
Barbič-Žagar, Breda | 22747 |
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