Čimbenike rizika čine stanja ili navike koje povečavaju rizik nastanka bolesti. Čimbenici rizika, poput arterijske hipertenzije, pušenja, povišene vrijednosti kolesterola i dijabetesa, značajno ...doprinose razvoju kardiovaskularnih bolesti koje su vodeči uzrok smrtnosti i pobola u industrijaliziranim zemljama. Inhibitori angiotenzin konvertirajučeg enzima smanjuju rizik od kardiovaskularnih događaja kod pacijenata sa svim razinama rizika. Brojne kliničke studije su već dokazale učinkovitost i sigurnost ramiprila u liječenju hipertenzije. Rezultati studije HOPE su već ukazali na jasne vaskularne i metaboličke prednosti terapije ramiprila. Ove prednosti su dosljedne bez obzira na prisutne čimbenike rizika bolesnika ili primjenu dodatnih liječenja. Kliničke studije Krkinog ramiprila su potvrdile njegovu učinkovitost u postizanju ciljnih razina arterijskog tlaka i ukazale na dodatne koristi kod visokorizičnih bolesnika.
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