Faculty of Pharmacy, Lj. (FFALJ)
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Učinkovitost i sigurnost ramiprila kao monoterapije i u fiksnoj kombinaciji s hidroklorotijazidom u liječenju različitih skupina hipertenzivnih bolesnika i njegov učinak na kardiovaskularnu prevenciju = The efficacy and safety of ramipril as monotherapy and in fixed-dose combination with hydrochlorothiazide in the treatment of different groups of hypertensive patients and its effect on cardiovascular preventionŽikić, Saša ; Grošelj, Mateja, farmacevtka ; Barbič-Žagar, BredaArterijska hipertenzija predstavlja vodeči zdravstveni problem u svijetu. Jedna od tri osobe ima visoke vrijednosti arterijskog tlaka (AT). Previsoka vrijednost pritiska na stijenke arterija ... uzrokovana visokim vrijednostima AT može uzrokovati oštečenje krvnih žila, kao i organa u tijelu. Nekontrolirano visoke vrijednosti AT mogu uzrokovati različite komplikacije. Hipertenzija je najmanje u dvije trečine svih slučajeva pračena čimbenicima kardiovaskularnog rizika poput dijabetesa, preboljelog infarkta miokarda ili moždanog udara, dislipidemije, pretilosti ili dokazane vaskularne bolest. Današnje liječenje hipertenzije je vrlo izazovno, posebno u bolesnika s povečanim kardiovaskularnim rizikom, pri čemu se od višestrukog farmakoloŽkog pristupa zahtijeva da se postigne prihvatljiva ciljna vrijednost AT. Ramipril je lipofilni ACE inhibitor pogodan za primjenu jednom dnevno. On učinkovito smanjuje perifernu vaskularnu rezistenciju regulirajuči tako visoki AT. U kombinaciji s hidroklorotijazidom ima sinergistički učinak koji povečava učinkovitost i sigurnost oba lijeka. Ramipril je istraživan u brojnim kliničkim studijama. Tako jer je istraživana i učinkovitost te sigurnost Krkinog ramiprila (Ampril) u nekoliko kliničkih i postautorizacijskih studijao sigurnosti i učinkovitosti. Krkin ramipril dostupan je u različitim jačinama i pakiranjima, uz fiksne kombinacije.Source: Kardio list. - ISSN 1846-0836 (Vol. 6, no. 9-10, 2011, str. 257-261)Type of material - article, component partPublish date - 2011Language - croatian, englishCOBISS.SI-ID - 3426929
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Database name | Field | Year |
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Žikić, Saša | ![]() |
Grošelj, Mateja, farmacevtka | 30292 |
Barbič-Žagar, Breda | 22747 |
Source: Personal bibliographies
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