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BRCA1/2 status and clinicopathologic characteristics of patients with double primary breast and ovarian cancerCvelbar, Martina ...The aim of the study was to analyse the results of BRCA1/2 testing in a group of patients with double primary breast and ovarian cancer (DPBOC) in Slovenia.Additionally, the family history and the ... clinicopathologic characteristics of BRCA1/2 mutation positive and negative patients with DPBOC were analysed, comparing them to a group of untested patients with DPBOC. For these groups of patients, survival analysis was also performed. From the 52 patients who were invited to genetic counselling and testing, 20 responded positively (38% compliance). BRCA1/2 mutations were found in 60% (12/20): 45% BRCA1 and 15% BRCA2 (9 and 3 patients, respectively). There was significantly higher grade of ovarian cancer and significantly higher rate of multiple primary breast cancer in BRCA1/2 positive group. Additionaly, there was a trend towards higher rate of first-degree family history of breast cancer, a trend towards higher stage of ovarian cancer, and a trend towards breast cancer being the first cancer in BRCA1/2 positive group. According to survivalanalysis, the tested group was not a representative sample of the larger untested group (of 51 patients), so we estimate that the rate of BRCA1/2 mutations in DPBOC patients is probably less than 60%.Source: Neoplasma. - ISSN 0028-2685 (Vol. 58, issue 3, 2011, str. 198-204)Type of material - article, component partPublish date - 2011Language - englishCOBISS.SI-ID - 28753881
Author
Cvelbar, Martina |
Hočevar, Marko, 1964- |
Vidmar, Gaj |
Teugels, Erik
Topics
Breast Neoplasms |
Pathology |
Genetics |
Ovarian Neoplasms |
Pathology |
Genetics |
Neoplasms, Multiple Primary |
Genes, Brca1 |
Mutation |
Survival Analysis |
Novotvorbe multiple primarne |
Dojka, novotvorbe |
Geni BRCA1 |
Jajčnik, novotvorbe |
Mutacija |
Preživetje, analiza
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Cvelbar, Martina | 14936 |
Hočevar, Marko, 1964- | 12023 |
Vidmar, Gaj | 17837 |
Teugels, Erik | ![]() |
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