National and University Library, Ljubljana (NUK)
-
Zaviralci poli (adenozin difosfat-riboza) polimeraze pri zdravljenju raka = Poly (adenosine diphosphate-ribose) polymerase inhibitors in cancer therapyKenig, SašaOlaparib, zaviralec poli (ADP-riboza) polimeraze (PARP) je prvo protutumorsko zdravilo, ki deluje po principu t.i. sintezne smrtnosti, odobreno za uporabo v kliniki, in sicer za zdravljenje raka ... jajčnikov za bolnice z mutacijo genov BRCA1 ali BRCA2, ki sta pomembna pri popravljanju poškodb DNA s homologno rekombinacijo. Leta 2016 so odobrili še en zaviralec PARP -rukaparib, v različnih fazah kliničnih raziskav pa jih je še več. Mutacije BRCA so značilne tudi za druge vrste raka, poleg tega pa obstaja še mnogo mutacij ali epigenetskih sprememb, ki imajo za celico podobne posledice - za vse te bi zaviralci PARP bili lahko uporabni. So torej obetavni za široko skupino onkoloških bolnikov, vendar pa je za načrtovanje zdravljenja potrebno tako natančno poznavanje mehanizma delovanja zaviralcev, skupaj z možnimi načini razvoja odpornosti, kot tudi poznavanje genetskega ozadja bolnika. V peiapwvku predstavljamo kratek pregled novih spoznanj o tej skupini zdravil in njihovi uporabi.Source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn.68, št. 3, jul. 2017, str. 203-209)Type of material - article, component partPublish date - 2017Language - slovenianCOBISS.SI-ID - 1539529668
Author
Kenig, Saša
Topics
homologna rekombinacija |
protitumorska zdravila |
olaparib |
rak (medicina) |
sintezna smrtnost |
zaviralci PARP
![loading ... loading ...](themes/default/img/ajax-loading.gif)
source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn.68, št. 3, jul. 2017, str. 203-209)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Kenig, Saša | 25525 |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location:
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi