Institute of Oncology, Lj. (OILJ)
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Adenokarcinom želodca, možnosti preprečevanja in predlogi za endoskopsko in histološko spremljanje predrakavih sprememb v želodcu = Gastric cancer, screening possibilities and proposals for endoscopic and histologic follow-up of premalignant gastric lesionsTepeš, Bojan ; Kavalar, RajkoIzhodišča: Rak želodca je drugi razlog smrti zaradi raka na svetu. V Sloveniji je rak želodca po incidenci in po vzroku smrti na šestem mestu. Med nevarnostne dejavnike za nastanek raka želodca ... spadajo: okužba z bakterijo Helicobacter pylori (H. pylori), mutacije gena E-catherin, polimorfizem provnetnih citokinov, hrana (sol, nitrozamini, vnos antioksidantov), perniciozna anemija, stanja 20 let po resekcijah želodca, bolniki z adenomi in redko hamartomi želodca, moški spol in kajenje. Ocenjujemo, da je 65 % do 80% vseh primerov raka želodca brez raka kardije posledica okužbe z bakterijo H. pylori. Polovica prebivalcev sveta je okužena z bakterijo, rak želodca pa se pojavi le pri 1 % okuženih. Zaključki: Osnovni pristop k zdravljenju raka želodca v državah, kjer je incidenca raka večja od 20/100.000 letno, bi moral biti presejanje prebivalstva na okužbo z bakterijo H. pylori in zdravljenje okužbe. To je tudi sklep Azijsko-pacifiškega konsenza iz leta 2008. Dokler ta pristop ne bo uveljavljen v praksi, pa je potrebno posebno pozornost posvetiti endoskopskemu in histološkemu spremljanju bolnikov s predrakavimi spremembami želodčne sluznice: atrofijo, intestinalno metaplazijo in displazijo. Članek prikazuje priporočila za endoskopsko in histološko sledenje, a tudi histološke značilnosti predrakavih in začetnih rakavih sprememb sluznice želodca.Source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 79, št. 4, apr. 2010, str. 366-374)Type of material - article, component part ; adult, seriousPublish date - 2010Language - slovenianCOBISS.SI-ID - 3651391
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source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 79, št. 4, apr. 2010, str. 366-374)
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Database name | Field | Year |
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Tepeš, Bojan | 07942 |
Kavalar, Rajko | 10772 |
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