The aim of this study is to determine the effectiveness of antenatal corticosteroid in reducing respiratory morbidity in babies born in the late preterm period.
Two hundred and eighty-six pregnant ...women at risk of having a late preterm delivery were studied. One hundred and forty-three (143) served as the cases and were given 2 doses of 12 mg intramuscular dexamethasone 12 h apart, while 143 served as the controls and were given a similar quantity of placebo. The women were followed up prospectively and data were collected on the pregnant women and their newborns on a standardized form. The neonates were assessed for acute respiratory distress syndrome and transient tachypnea of the newborn based on clinical signs, symptoms, and chest x-ray results (when indicated). The primary outcome was the occurrence of neonatal respiratory morbidity.
The primary outcome occurred in 5 out of 130 infants (3.8%) in the dexamethasone group and 31 out of 122 (25.4%) in the placebo group (P value = 0.000003). Birth asphyxia, neonatal intensive care admission and need for active resuscitation at birth also occurred significantly less frequently in the dexamethasone group (P value 0.004, 0.009, 0.014 respectively). There were no significant group differences in the incidence of neonatal sepsis, neonatal jaundice, hypoglycemia and feeding difficulties.
Administration of dexamethasone to women at risk for late preterm delivery significantly reduced the rate of neonatal respiratory complications, neonatal intensive care unit admission, and need for active resuscitation at birth.
PACTR ( www.pactr.org ) Registration Number: PACTR202304579281358. The study was retrospectively registered on April 19, 2023.
Respiratory viral infections are a leading cause of disease worldwide. A variety of respiratory viruses produce infections in humans with effects ranging from asymptomatic to life-treathening. ...Standard surveillance systems typically only target severe infections (ED outpatients, hospitalisations, deaths) and fail to track asymptomatic or mild infections. Here we performed a large-scale community study across multiple age groups to assess the pathogenicity of 18 respiratory viruses. We enrolled 214 individuals at multiple New York City locations and tested weekly for respiratory viral pathogens, irrespective of symptom status, from fall 2016 to spring 2018. We combined these test results with participant-provided daily records of cold and flu symptoms and used this information to characterise symptom severity by virus and age category. Asymptomatic infection rates exceeded 70% for most viruses, excepting influenza and human metapneumovirus, which produced significantly more severe outcomes. Symptoms were negatively associated with infection frequency, with children displaying the lowest score among age groups. Upper respiratory manifestations were most common for all viruses, whereas systemic effects were less typical. These findings indicate a high burden of asymptomatic respiratory virus infection exists in the general population.
We analyse up-to-date epidemiological data of the Ebola virus disease outbreak in Nigeria as of 1 October 2014 in order to estimate the case fatality rate, the proportion of healthcare workers ...infected and the transmission tree. We also model the impact of control interventions on the size of the epidemic. Results indicate that Nigeria’s quick and forceful implementation of control interventions was determinant in controlling the outbreak rapidly and avoiding a far worse scenario in this country.
Iron (Fe) toxicity is recognized as one of the most widely spread soil constraints for rice production especially in West Africa. Oryza glaberrima the cultivated rice species that originated from ...West Africa is well-adapted to its growing ecologies. The aim of this study was to identify the promising O. glaberrima accessions tolerant to Fe toxicity from the 2106 accessions held at the AfricaRice gene bank. The screenings were conducted over a four-year period and involved evaluating the entries under Fe-toxic field conditions in West Africa, selecting good yielding accessions and repeating the testing with newly selected lines. Three accessions (TOG 7206, TOG 6218-B and TOG 7250-A) were higher yielding than O. sativa checks under stress but with similar yields under control conditions. These accessions yielded over 300g/m2 under both Fe toxicity and control conditions. In conclusion, these materials could be used as donors in breeding programs for developing high yielding rice varieties suited to Fe toxicity affected areas in West Africa.
Chloride diffusion through concrete is influenced by harsh environmental conditions such as high ambient temperature and relative humidity. This paper examined the influence of temperature gradient ...on chloride diffusion in concrete under high ambient temperature conditions. Chloride diffusion tests using cylindrical concrete samples were performed in constant temperature and temperature gradient conditions. In a temperature gradient condition, a much higher chloride concentration was measured than at constant temperatures, which could not be explained only by the mass diffusion driven by the concentration gradient. A new analytical model of chloride diffusion with the mass diffusion term including the temperature effect and the thermo-diffusion term including the temperature gradient effect was applied to the results, which showed that the thermo-diffusion contribution was significant. Using the analytical model with the mass diffusion (DCl) and thermo-diffusion (DT) coefficients, the service life of reactor containment buildings (RCBs) in nuclear power plants (NPPs) in the Middle Eastern and North African (MENA) region was estimated. The results showed that the service life of the RCBs could be reduced by the temperature gradient, indicating the possible application of the proposed analytical model.
•Chronic exposure to EOMABRSL increased the markers of liver toxicity and kidney failure•Chronic exposure to mixture of environmental toxicants decreased the key markers of hepatorenal ATP•Phenolic ...antioxidants from Croton zambiscus leaves promoted hepatorenal wellness.
Chronic exposure of mixed-metal intoxication has been associated with prolonged oxidative stress and severe hepatorenal damage. This present study demonstrates the hepatoprotective and renoprotective activity of Croton zambesicus (C-ZAMB) leaves, naturally occurring phenolic compounds against chronic mixed-metal (EOMABRSL) induced toxicity. 0.5 ml of EOMABRSL via oral route induced chronic hepatoxicity and nephrotoxicity on exposure for 98 days (non-withdrawal) and 70 days (withdrawal) by abnormal alteration in the levels of endogenous antioxidants. Moreover, EOMABRSL induced hepatorenal damage by increasing the markers of liver toxicity (ALT, AST, ALP, GGT and bilirubin) and kidney failure (creatinine, urea, uric acid, and renal electrolytes-Na+ and K+). Both non-withdrawal and withdrawal approaches of EOMABRSL-exposed animals exhibited hepatorenal dysfunctions by increasing the activity of eco-51-nucleotidase (51ENT) followed by the decreased in the activity of lactate dehydrogenase (LDH)-index of cellular ATP. These results were further supported by the histopathological examination of nephritic cells, hepatocytes and splenocytes, manifested by hepatocellular necrosis, swelling or degeneration of tubular kidney epithelial cells as well as coalescing splenic periarteriolar lymphoid sheaths (PALSs) and lymphoid haemosiderin. The chronic EOMABRSL intoxication was ameliorated by administration of phenolic antioxidants from C-ZAMB leaves. Therefore, our study supports the view that phenolic C-ZAMB leaves may mediate hepatorenal wellness on chronic exposure to mixed-metal intoxication
Prior caesarean delivery (CD) impacts CD rates in many parts of the world. In low and middle-income countries, few women attempt a trial of labour after caesarean delivery (TOLAC) due to inadequate ...resources for safe vaginal birth after caesarean delivery (VBAC). The CD rates continue to rise as more women undergo repeat CD. In Nigeria, VBAC rate is low and the contribution of women's prior childbirth experiences and delivery wishes to this situation deserves further investigation. This study examined the parturient factor in the low VBAC rate to recommend strategies for change.
To describe prior caesarean-related childbirth experiences and attitudes towards subsequent vaginal birth in pregnant women with one previous CD.
This cross-sectional study of antenatal clinic attendees in a tertiary hospital employed the convenience sampling method to recruit 216 consenting women with one previous CD. Structured questionnaires were used to collect information on participants' prior caesarean-related birth experiences, attitudes to vaginal birth in the index pregnancy, future delivery intentions and eventual delivery route. Univariate and bivariate analyses compared delivery wishes based on CD type. SPSS version 22.0 was used for data analysis.
The modal maternal and gestational age groups were 30-39 years (68.1%) and 29-34 weeks (49.1%) respectively; majorities (60.6%) were secundigravida; 61.6% experienced labour before their CDs while 76.9% had emergency CDs. Complications were documented in 1.4% and 11.1% of mothers and babies respectively. Ninety percent reported a satisfactory overall childbirth experience. A majority (83.3%) preferred TOLAC in the index pregnancy because they desired natural childbirth while 16.7% wanted a repeat CD due to the fear of fetal-maternal complications. The previous CD type and desire for more babies were significantly associated with respondents' preferred mode of delivery (p = 0.001 and 0.023 respectively). Women with previous emergency CD were more likely to prefer vaginal delivery.
Antenatal women prefer TOLAC in subsequent pregnancies despite prior satisfactory caesarean-related birth experiences. Adoption of TOLAC in appropriately selected cases will impact women's psyche positively and reduce CD rate.
The two-tank water system is common practice for the storage and distribution of water in many homes. Water is transported via a pipeline network from the storage tank (lower tank) to the ...distribution tank (overhead tank) using an electric pumping machine. Due to limited control in the existing pumping system, water wastage becomes inevitable. Determining the quality of water in the overhead tank before supply in the home is still unaddressed. In this work, an integrated Android mobile App and a control system were developed to assess the water quality, perform level check in the overhead tank, and activate intelligent pumping control. An ultrasonic pulse-echo technique was used for water level checks, while the water turbidity and pH signals were used for water quality checks. Three-level control conditions (LC_1, LC_2, LC_3) and two water quality check conditions (QC_1 and QC_2) were devised and used in the intelligent control algorithm of the system. Control valve1 regulates the flushable poor water quality while valve2 regulates the house's supply of good water quality. The absolute relative error between the expected time and the system time of filling the tank level was observed to be less than 10% when the water volume is less than 81%. Hence, distortion in the sensory signals increases and worsen as the water level approaches the ultrasonic sensor position. The poor internet signal network was observed to affect the real-time monitoring and automation of the system control through delay in system responses to commands. However, the average recorded response time of the system is 3 s, and it could be less in the situation of good internet network services.
Firebase, Pitch-catch, Pulse-echo, Time-of-flight, Turbidity, pH scale.
Reductions in sperm quality due to free radical formation during cancer chemotherapy are well documented, hence the need for an adjunct antioxidant treatment during chemotherapy. This study was ...designed to investigate the effects of N-acetylcysteine on sperm quality following cyclophosphamide exposure in male Wistar rats.
wenty male Wistar rats weighing 150-170g were randomly assigned into 4 groups of five rats each, and were orally administered distilled water (Control), Cyclophosphamide (6mg/kg), N-acetylcysteine (100mg/kg) or Cyclophosphamide + N-acetylcysteine for 21 days. Sperm count, histone-protamine replacement, chromatin integrity, testicular histomorphometry and BAX Protein expression were assessed using standard procedures. The data was presented as mean ± SEM and analyzed using students' t- test. A
<0.05 was considered significant.
Sperm counts were significantly reduced (
<0.05) among the cyclophosphamide (69.95±7.78 x10
/ml) and cyclophosphamide + N-acetylcysteine (64.78±3.52 x10
/ml) treated rats, while it increased significantly (
<0.05) in the N-acetylcysteine (132.20±28.71 x10
/ml) treated rats compared to the control animals (115.30±8.70x10
/ml). Increased interstitial space distance, degenerated Leydig cells and impaired histone-protamine replacement observed among the cyclophosphamide-treated rats were ameliorated in the cyclophosphamide + N-acetylcysteine-treated rats. Sperm chromatin integrity, which was poor in the cyclophosphamide-treated rats, was considerably improved when compared with the Control and the N-acetylcysteine-treated rats. Bax protein expression was reduced in the cyclophosphamide (20%) and cyclophosphamide+N-acetylcysteine (20%) groups when compared with the Control (50%) and N-acetylcysteine (50%) groups.
We concluded that N-acetylcysteine might improve sperm histone protamine replacement, which is one of the stage-specific effect of cyclophosphamide toxicity.
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