Four new mixed-ligand divalent coordination polymers (CPs) Cu2(muco)2(4-clpy)2 (1), Cu2(muco)2(4-brpy)2 (2), Zn2(bdc)2(4-clpy)2 (3), and Zn2(bdc)2(4-brpy)2 (4) (H2muco = trans,trans-muconic ...acid or 1,3-butadiene-1,4-dicarboxylic acid; H2bdc = 1,4-benzene dicarboxylic acid; 4-clpy = 4-chloropyridine and 4-brpy = 4-bromopyridine) have been synthesized and well characterized by elemental analysis, infrared spectra, single-crystal X-ray diffraction techniques, powder X-ray diffraction patterns, and thermogravimetric analysis. All the compounds 1–4 have a two-dimensional (2D) coordination polymeric sheet structure. Of these, 1 and 2 are isotypical and form a 3D supramolecular aggregation based on type-I halogen–halogen interactions (Cl···Cl or Br···Br) and have an impact on CO2 sorption properties. For the first time, halogen–halogen interactions have been used as a tool in the construction of high-dimensional CPs for sorption studies. However, analogous compounds 3 and 4 are expanded to 3D supramolecular structures based on π···π interactions. These compounds have no halogen–halogen interactions and hence become nonporous toward CO2 sorption. It appears that the halogen–halogen interactions between the 2D sheets are desirable for the uptake of CO2 gas.
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Naringenin, a natural dihydrochalcone flavonoid, exhibits diverse pharmacological properties. This study investigates the hypolipidemic effects of Nar-NPs on obese mice. The ...characteristics of Nar-NPs, including morphology, particle size, zeta potential, UV–vis, and FT-IR spectra, were examined. The anti-obesity properties of Nar-NPs were evaluated in obese rats, considering LD50, 1/20 LD50, and 1/50 LD50 for treatment preparation. Results indicated that synthesized Nar-NPs were uniform, spherical, and well-dispersed, with a size of 130.06 ± 1.98 nm and with a zeta potential of −25.6 ± 0.8 mV. Nar-NPs exhibited enhancement in the cumulative release of naringenin (56.87 ± 2.45 %) as compared to pure naringenin suspension 87.83 ± 1.84 % in 24 h of the study. The LD50 of Nar-NPs was determined as 412.5 mg/kg.b.w. HFD induced elevated glycemic, oxidative stress, and inflammatory biomarkers while reducing HDL-C, GSH, and superoxide dismutase (SOD) levels. Administration of Nar-NPs significantly mitigated body weight, glucose, insulin, leptin, TC, TG, SREBP1c, pAMPK, PPAR-α, as well as vanin-1, MCP-1, and iNOS mRNA gene expression. Histological investigations supported the biochemical and PCR findings. In a nutshell, the study suggests that the Nar-NPs could serve as a promising and viable pharmacological strategy for the treatment of obesity-related disorders.
CL spectra for the quantitative analysis of GFLX; (4) calcein–KMnO4 system, (5) calcein–KMnO4–GFLX system and (6) calcein–KMnO4–GFLX–AgNP system; conditions: GFLX=1.0×10−5M, calcein=1.0×10−4M, ...KMnO4=7.0×10−4M, NaOH=0.05M, AgNP=5.0×10−4M. Display omitted
•Precise and reliable method was developed for the determination of gatifloxacin.•Silver nanoparticle was used as chemiluminescence enhancer.•This method is easily performed and affords good precision and accuracy.•The sensitivity of this technique does not affected by coexisting ions/compounds.•The method was successfully applied to analysis of drug and spiked urine.
Silver nanoparticles have been utilized for the enhanced chemiluminogenic estimation of fluoroquinolone antibiotic gatifloxacin. It has been found that the weak chemiluminescence intensity produced from the reaction between calcein and KMnO4 can further be strengthened by the addition of silver nanoparticles in the presence of gatifloxacin. This phenomenon has been exploited to the quantitative determination of gatifloxacin. Under the optimum experimental conditions, the calibration curves are linear over the range of 8.9×10−9–4.0×10−6M, while the limits of detections were found to be 2.6×10−9M with correlation coefficient value (r2) 0.9999. The relative standard deviation calculated from six replicate measurements (1.0×10−4M gatifloxacin) was 1.70%. The method was applied to pharmaceutical preparations and the results obtained were in reasonable agreement with the amount labeled on the formulations. The proposed method was also used for the determination of gatifloxacin in spiked urine samples with satisfactory results. No interference effects from some common excipients used in pharmaceutical preparations have been found.
A Co(II) based coordination polymer (CP) Co2(ip)2(4-phpy)4•(H2O)2 has been synthesized by slow diffusion method in a single pot technique using angular ligand isophthalic acid (H2ipa) and monodentate ...N-donor ligand 4-phenylpyridine (4-phpy). The synthesized material has been structurally characterized by single crystal (SCXRD), which reveals that the synthesized compound consists of one-dimensional (1D) chain and each 1D chain polymers undergo hydrogen bonding interactions to generate ribbon like 1D double chain ladder polymer. These ladder polymers are stacked together via π···π interactions among aromatic rings of neighboring isophthalate to fabricate 2D layer structure. Hirshfeld surface analysis further confirms the possible extensive intermolecular interactions. The biological affinity behavior of the compound has been realized determining extent of interaction using Docking study.
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•X-ray crystallographic analysis of a new Co(II)-based coordination polymer exhibit 3D supramolecular architecture.•Structural analysis reveals the formation of 2D coordination polymer composed of ribbon like 1D double chain ladder polymer.•Supramolecular network is formed by means of various non-covalent interactions, including hydrogen bonding, CH⋯π and π⋯π stacking.•The compound reveals biological affinity as examined by Docking study.
A Co(II) compound Co2(ip)2(4-phpy)4·(H2O)2 (1); (H2ip = isophthalic acid and 4-phpy = 4-phenylpyridine) has been synthesized employing slow diffusion technique. Single crystal X-ray analysis reveals that compound 1 crystallizes in the triclinic system, space group P1¯ with a = 10.7041(3) Å, b = 14.2959(4) Å, c = 18.3474(5) Å; α = 73.3930(10)°, β = 76.0190(10)°, γ = 88.4780(10)° with V = 2608.06(13) Å3. The compound 1 forms based one-dimensional coordination polymer (1D CP) constructed by distorted octahedral Co(II) centres, which are interconnected via strands of isophthalate bridges resulting in a 1D chain polymer. The pyridine-based ligands are decorated as arms on both sides of Co(II) centers. The unique coordinating characteristics of isophthalate and pyridine ligands are accounted for the strong affinity towards DNA molecules for compound1. The binding affinities of compound 1 with DNA have been investigated via docking studies. Hirshfeld surface analysis was performed in order to check out the nature of intermolecular interactions and packing modes of compound 1 in the crystalline state.
A Cu(II) based 1D zig–zag coordination polymer Cu2(5-nip)2(3-brpy)2·(H2O)2·(DMF)2 (1); (H25-nip = 5-nitroisophthalic acid and 3-brpy = 3-bromopyridine) was synthesized and characterized by single ...crystal X-ray diffraction, powder X-ray diffraction, UV–Vis spectroscopy, IR spectroscopy and TGA analysis. The interaction between CT-DNA was illustrated through a Benesi-Hildebrand plot. Finally, docking study was conducted to assess its DNA binding affinity.
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A Cu(II) compound Cu2(5-nip)2(3-brpy)2·(H2O)2·(DMF)2 (1) was synthesized using 5-nitroisophthalic acid (H25-nip) and 3-bromopyridine (3-brpy) employing slow diffusion technique. Visibly distinct blue-colored crystals of compound 1 were obtained. Single crystal X-ray analysis discloses that compound 1 crystallizes in the triclinic system, having space group P1¯ with cell dimensions a = 12.4491(14) Å, b = 13.6238(15) Å, c = 14.3315(15) Å; α = 68.027(3)°, β = 69.914(3)°, γ = 87.173(3)°and V = 2108.3(4)Å3. The compound contains core metal atom Cu(II) that is hexa-coordinated to 5-nip, 3-brpy, dimethylformamide (DMF), and aqua molecule resulting in one- dimensional coordination polymer (1D CP), propagated via strands of 5-nip bridges. The pyridine-based ligand and aqua ligands are decorated as arms on both sides of Cu(II) centers. The prominence of hydrogen bonding interactions in compound 1 was found which leads to the formation of 1D double-chain strand. The combination of 5-nip and 3-brpy ligands is responsible for the strong affinity towards DNA molecules for compound1. Docking studies have been employed to examine DNA binding affinity. Hirshfeld surface analysis was carried out in order to check out the nature of intermolecular interactions and packing modes of compound 1 in the crystalline state.
A new nickel(II) compound, Ni(NCS)2(4-nvp)4 4-nvp = 4-naphthylvinylpyridine (1) has been synthesized which shows significant CH⋯π interactions in the formation of a supramolecular 3D network ...structure. Hirshfeld surfaces analysis was performed to investigate non-covalent interactions in the crystal packing. Compound 1 shows DNA binding affinity as confirmed by molecular docking study. The binding was driven by a negative free energy change, −3.65 kcal/mole which compensated free energy change (2.2 kcal/mole) of DNA helix. During binding, the compound was stabilized by hydrogen bond as well as π⋯π interaction between DNA base pair and naphthalene ring of the ligand.
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•A nickel(II) based compound with 4-naphthylvinylpyridine ligand has been synthesized.•Cmpound 1 shows significant CH⋯π interactions to form supramolecular 3D network structure.•Compound 1 exhibits DNA binding affinity studied via molecular docking study.
A new nickel(II) compound, Ni(NCS)2(4-nvp)4 4-nvp = 4-(1-naphthylvinyl)pyridine 1 was synthesized and characterized by elemental analysis as well as single-crystal X-ray diffraction (SCXRD) technique. Compound 1 crystallized in triclinic space group Pī. It exhibited significant CH⋯π interactions leading to supramolecular 3D network structure. Hirshfeld surfaces analysis was performed to investigate non-covalent interactions in the crystal packing. Compound 1 was investigated for DNA binding (in silico) by molecular docking study. The binding was driven by a negative free energy change, −3.65 kcal/mole which compensated free energy change (2.2 kcal/mole) of DNA helix. During binding, the compound was stabilized by hydrogen bond as well as π⋯π interaction between DNA base pair and naphthalene ring of the ligand.
This article describes the synthesis of a new Zn(II)-based three-dimensional coordination polymer (3D CP) Zn2(4,4′-dsb)2(4,4′-bpy)3·(solvent) x H24,4′-dsb = 4,4′-disulfanediyldibenzoic acid and ...4,4′-bipyridine (4,4′-bpy) (1). Here, the originally used 4-mercaptobenzoic acid (4-mba) undergoes in situ dimerization via the S–S bond to produce H24,4′-dsb. Fascinatingly, compound 1 exhibits a scarcely reported self-catenated 5-connected underlying net with point symbol {42·68}. As far as our knowledge is concerned, this tangled network is the first of this kind among CPs. The calculated highest occupied molecular orbital–lowest unoccupied molecular orbital (HOMO–LUMO) band gap computed from density functional theory (DFT) calculation along with well-corroborated experimental values obtained by Tauc’s plot reveals the conducting nature of the synthesized material.
•X-ray crystallographic analysis of a new Zn(II)-based metal-organic framework (MOF).•Structural analysis reveals the formation of 2D square-grid framework with (4,4) net topology.•In situ cis-trans ...isomerization of cis,cis- muconate ligand in visible light.•The compound reveals photoluminescence property as examined by fluorescence spectroscopy.
A Zn(II) based two-dimensional (2D) metal-organic framework (MOF) Zn3(cis,trans-muco)3(4,4′-bpy)3·4H2O (1) has been synthesized by slow diffusion method using cis,cis-muconic acid (H2cis,cis-muco) and 4,4′-bipyridine (4,4′-bpy) mixed ligands. The synthesized compound 1 has been structurally characterized by single crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD) techniques, and thermogravimetric analysis (TGA). The solid-state structure of 1 reveals in situ cis,cis- to cis, trans- isomerization of muconate ligand under visible light, which predominately coordinates to Zn(II). The compound 1 comprises binuclear Zn2 secondary building units (SBUs) which propagate in ab plane to furnish 2D framework with (4,4) net topology. Interestingly, compound 1 shows photoluminescence property and can be used as luminescent probe. The non-covalent interactions within the compound 1 have been investigated by means of Hirshfeld surface analysis.
A Zn(II) based two-dimensional (2D) metal-organic framework (MOF) Zn2(cis,trans-muco)2(4,4′-bpy)2·4H2O has been synthesized by slow diffusion technique. The synthesized material has been structurally characterized by single crystal (SCXRD), powder X-ray diffraction techniques (PXRD), and thermogravimetric analysis (TGA). Here, cis,cis-muconate ligand has been transformed into a cis,trans-muconate ligand prior to the formation of MOF. This is quite unanticipated because no cis,trans-muconate was introduced in the reaction, and the starting material used cis,cis-muconic acid was pure. To the best of our knowledge, no such example was reported for cis,trans transformation of cis,cis-muconate ligand in the synthesis of MOFs. The photoluminescence of the compound has also been studied. Display omitted
