The discovery of bulk metallic glasses (BMGs) has stimulated widespread research enthusiasm because of their technological promise for practical applications and scientific importance in ...understanding glass formation and glass phenomena. Arising from their disordered atomic structure and unique glass-to-supercooled liquid transition, BMGs represent a new class of structural and functional materials with extraordinary properties including extreme strength at low temperature and high flexibility at high temperature, along with a number of superior chemical and physical properties. This article covers the general properties of BMGs based on a review of the historical milestones in metallic glass research, and recent progress on several fundamental issues in the development of a comprehensive understanding of the strength, ductility and glass-forming ability of BMGs and, more importantly, the correlation of these parameters with atomic structure, focusing on the outstanding questions and critical issues that appear to warrant future research. Recent advances in the applications of BMGs in microelectromechanical systems (MEMS), biomedicine and nanotechnology are also reviewed.
Objective To investigate the expression and clinical significance of TM9SF3 in lung adenocarcinoma (LUAD). Methods TCGA and GEPIA databases were used to screen the differentiallyexpressed TM9SF ...family molecules and analyze their effects on patient prognosis with LUAD. The expression and localization of TM9SF3 in LUAD patients were verified by a human proteomic mapping database, Western blot assay, and polymerase chain reaction assay. Herein, the GSEA was used for the signal pathway enrichment analysis of TM9SF3-related genes. Meanwhile, the TIMER database and CIBERSORT algorithm were used to analyze the correlation between differentially-expressed TM9SF3 and the degree of immune cell infiltration. Results The expression of TM9SF3 in LUAD was significantly increased and had a significant adverse effect on the prognosis of LUAD patients. In addition, immunoblotting and polymerase chain reaction confirmed that TM9SF3 was highly expressed in LUAD. Meanwhile, the genes related to TM9SF3 expression were mainly enri
Objective Slug flow is one of the main gas-liquid two-phase flow regimes. Its fluctuation characteristics not only impact the safe operation of multi-phase pumps and the measurement accuracy of ...multi-phase flowmeters but also arouse flow-induced vibrations in various pipeline sectors, such as elbows, valves, and places where pipelines are connected in parallel. Therefore, conducting a systematic study on fluctuation frequencies induced by slug flow is of utmost importance for securing the operation safety of these pipelines and associated fittings. Methods By leveraging the dynamics model of slug flow and recognizing the inherent continuity wave characteristics of slug flow, a novel continuity wave model was developed. This model employed the Strouhal number to characterize the dimensionless fluctuation frequencies induced by slug flow. Through extensive literature investigations, existing empirical calculation models for fluctuation frequencies induced by slug flow in horizontal pipelines were summarized
Objective To investigate the effects of nucleotide binding oligomerization domain-like receptor family caspase recruitment domain containing 3 (NLRC3) on the proliferation, migration and invasion of ...human colon cancer HCT116 and LoVo cells. Methods NLRC3 was knocked down in HCT116 and LoVo cells by NLRC3-specific siRNA (si-NLRC3). NLRC3 mRNA and protein expression was detected by real-time quantitative PCR and Western blotting. The proliferation ability of cancer cells was detected by CCK-8 assay; the clone formation ability was detected by clone formation assay; the invasion ability was detected by Transwell
assay; the migration ability was detected by cell scratch healing assay. Results The transfection of si-NLRC3 down-regulated the expression of NLRC3 in HCT116 and LoVo cells. After NLRC3 knockdown, the proliferation and invasion ability of colon cancer cells were significantly strengthened and the cell migration was not significantly changed. Conclusion Knockdown of NLRC3 in HCT116 and LoVo cells can enh
To explore the clinical characteristics and genetic etiology of a child with multiple pterygium syndrome (MPS).
A child with MPS who was treated at the Orthopedics Department of Guangzhou Women and ...Children's Medical Center Affiliated to Guangzhou Medical University on August 19, 2020 was selected as the study subject. Clinical data of the child was collected. Peripheral blood samples of the child and her parents were also collected. Whole exome sequencing (WES) was carried out for the child. Candidate variant was validated by Sanger sequencing of her parents and bioinformatic analysis.
The child, an 11-year-old female, had a complain of "scoliosis found 8 years before and aggravated with unequal shoulder height for 1 year". WES results revealed that she has carried a homozygous c.55+1G>C splice variant of the CHRNG gene, for which both of her parents were heterozygous carriers. By bioinformatic analysis, the c.55+1G>C variant has not been recorded by the CNKI, Wanfang data knowledge service platform and HGMG
BackgroundWith the development of negative ion based neutral beam injection system (NNBI) for China fusion engineering test reactor (CFETR), the output power control system of its supporting the ...radio frequency (RF) power source is one of the key technologies to realize the improvement of its performance.PurposeThe study aims to design an improved output power control system of RF power source to solve the problems of output power stability and insufficient control accuracy in the use of existing RF power sources.MethodsThe software and hardware separation control structure designed by ARM+CPLD dual-core were employed to ensure the operation efficiency of the output power control algorithm of the RF power source and the communication stability of the peripheral equipment. Multi-stage progressive power control method and 12-bit digital signal were adopted to control the opening and closing of RF power amplifier, so as to realize high-precision control of output power. The capacitive voltage divider method and
As the key equipment of data acquisition in oil and gas exploration, the node can be replaced by a mechanical arm because of its long-term continuous work and high efficiency, but the structure ...rigidity is weak and the motion ability is poor, so the structure optimization and lightweight design are carried out to improve the structure rigidity and motion ability. Based on the screw theory, the forward kinematics equation of the manipulator with node placement is established, the global static stiffness index and the global velocity index considering the direction of the task are proposed, and the mathematical model of the size optimization of the node-placing manipulator is established. Based on the multi-objective particle swarm algorithm and the variable density method, the size optimization and lightweight design of the node-distributed manipulator arm are carried out. The results show that the overall static stiffness index and the overall velocity performance in the mission direction are improved by 19.8
Objective: Rice bran esterase was extracted from rice bran using natural deep eutectic solvents (NADES) as media and the extraction processing of parameters was systematically optimized. The higher ...purity of rice bran esterase was obtained after purified with DEAE column and its enzyme properties were also investigated. Methods: Ten kinds of NADES including organic acids-based, polyols-based, amine-based and amino acids-based NADES were prepared. The extraction procedures including water bath agitation and ultrasonication were carried out. The effects of single factor such as the solid-to-liquid ratio, water content, extraction temperature and time on enzyme activity was studied. And then response surface methodology was used for optimization of the extraction processing. The crude enzyme solution was purified using DEAE column, as well as its enzyme characteristics were investigated. Results: The rice bran esterase activity of 2.96 U was obtained under the extraction conditions of proline-glycerol (molar rat
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