Attention - here, the selection of visual information - is necessary for the control of skills and procedures. In amendment of the principles discussed by Luck et al. Luck, S. J., Gaspelin, N., Folk, ...C. L., Remington, R. W., & Theeuwes, J. (2021). Progress toward resolving the attentional capture debate. Visual Cognition, 29(1), 1-21. https://doi.org/10.1080/13506285.2020.1848949, we review evidence for this general influence: the moderating influence of stimulus awareness on attention capture by abrupt onsets; and the influence of linguistic differences between languages on stimulus-driven attention capture.
Inclusive science in the South Atlantic Perez, Renellys; Garzoli, Silvia; Hummels, Rebecca ...
Communications earth & environment,
12/2023, Volume:
4, Issue:
1
Journal Article
Peer reviewed
Open access
The South Atlantic Meridional Overturning Circulation initiative began as a grassroots effort to study the South Atlantic Ocean and its impact on climate. In striving towards this goal, it has also ...become a platform for the empowerment of women and international scientists.The South Atlantic Meridional Overturning Circulation initiative began as a grassroots effort to study the South Atlantic Ocean and its impact on climate. This Comment discusses how, in striving towards this goal, it has also become a platform for the empowerment of women and international scientists.
Engaging in yoga may mitigate stress and anxiety in individuals while potentially enhancing one's capacity to manage distractions. Our research aimed to explore the relation between these two ...outcomes: Can an eight-week yoga program foster distraction suppression, thereby reducing stress and discomfort? To answer this question, we used Hatha Yoga, the most commonly practiced form of yoga. We tested if the intervention improved participants' ability to suppress distractions and selectively decrease self-reported stress and stress reactivity. In Addition, we investigated whether such an intervention would increase participants' mindfulness. Our study included 98 healthy yoga novices between 18 and 40 years who were randomly assigned to either an experimental or a waitlist condition, with each participant completing pre- and post-intervention assessments, including questionnaires, as well as electrophysiological and behavioral measures. After eight weeks of yoga practice, significant reductions in self-reported stress and stress reactivity levels, as well as increased mindfulness, were observed among those participating in the intervention relative to those in the waitlist control group. There were, however, no significant changes in state or trait anxiety due to the intervention. Changes in stress measures could not be explained by changes in participants' ability to suppress distractors, which was not affected by the intervention. Overall, our findings suggest that regular participation in Hatha Yoga can improve mental health outcomes without impacting cognitive functioning directly related to distractor suppression.
NCT05232422
Sounds in our environment can easily capture human visual attention. Previous studies have investigated the impact of spatially localized, brief sounds on concurrent visuospatial attention. However, ...little is known on how the presence of a continuous, lateralized auditory stimulus (e.g., a person talking next to you while driving a car) impacts visual spatial attention (e.g., detection of critical events in traffic). In two experiments, we investigated whether a continuous auditory stream presented from one side biases visual spatial attention toward that side. Participants had to either passively or actively listen to sounds of various semantic complexities (tone pips, spoken digits, and a spoken story) while performing a visual target discrimination task. During both passive and active listening, we observed faster response times to visual targets presented spatially close to the relevant auditory stream. Additionally, we found that higher levels of semantic complexity of the presented sounds led to reduced visual discrimination sensitivity, but only during active listening to the sounds. We provide important novel results by showing that the presence of a continuous, ongoing auditory stimulus can impact visual processing, even when the sounds are not endogenously attended to. Together, our findings demonstrate the implications of ongoing sounds on visual processing in everyday scenarios such as moving about in traffic.
Serotonin and dopamine are associated with multiple psychiatric disorders. How they interact during development to affect subsequent behavior remains unknown. Knockout of the serotonin transporter or ...postnatal blockade with selective serotonin reuptake inhibitors (SSRIs) leads to novelty-induced exploration deficits in adulthood, potentially involving the dopamine system. Here, we show in the mouse that raphe nucleus serotonin neurons activate ventral tegmental area dopamine neurons via glutamate co-transmission and that this co-transmission is reduced in animals exposed postnatally to SSRIs. Blocking serotonin neuron glutamate co-transmission mimics this SSRI-induced hypolocomotion, while optogenetic activation of dopamine neurons reverses this hypolocomotor phenotype. Our data demonstrate that serotonin neurons modulate dopamine neuron activity via glutamate co-transmission and that this pathway is developmentally malleable, with high serotonin levels during early life reducing co-transmission, revealing the basis for the reduced novelty-induced exploration in adulthood due to postnatal SSRI exposure.
In Parkinson’s disease, misfolded α-synuclein accumulates, often in a ubiquitinated form, in neuronal inclusions termed Lewy bodies. An important outstanding question is whether ubiquitination in ...Lewy bodies is directly relevant to α-synuclein trafficking or turnover and Parkinson’s pathogenesis. By comparative analysis in human postmortem brains, we found that ubiquitin immunoreactivity in Lewy bodies is largely due to K63-linked ubiquitin chains and markedly reduced in the substantia nigra compared with the neocortex. The ubiquitin staining in cells with Lewy bodies inversely correlated with the content and pathological localization of the deubiquitinase Usp8. Usp8 interacted and partly colocalized with α-synuclein in endosomal membranes and, both in cells and after purification, it deubiquitinated K63-linked chains on α-synuclein. Knockdown of Usp8 in the Drosophila eye reduced α-synuclein levels and α-synuclein–induced eye toxicity. Accordingly, in human cells, Usp8 knockdown increased the lysosomal degradation of α-synuclein. In the dopaminergic neurons of the Drosophila model, unlike knockdown of other deubiquitinases, Usp8 protected from α-synuclein–induced locomotor deficits and cell loss. These findings strongly suggest that removal of K63-linked ubiquitin chains on α-synuclein by Usp8 is a critical mechanism that reduces its lysosomal degradation in dopaminergic neurons and may contribute to α-synuclein accumulation in Lewy body disease.
Task cues that correctly (vs.incorrectly) inform humans about their upcoming tasks, benefit (vs. interfere with) performance because participants can use task cues to retrieve the corresponding task ...set, so that targets can (vs. cannot) be processed according to the currently applying task set from target onset onwards. Here, we tested if task-associated features of peripheral cues have a similar effect. Typically, peripheral cues with a task-associated, searched-for color (i.e., top-down matching cues) capture attention: Search for targets presented at the cued position (valid condition) is faster than for targets presented away from the cue (invalid condition), even if cues do not predict the likely target location. For example, when searching for red and green targets, a red cue captures attention even if presented prior to a green target, but a blue cue does not. We know that cue-target color congruence—whether the cue has a target-similar color (congruent case) vs. a target-dissimilar color (incongruent case)—additionally expedites vs. delays search times. However, it is unclear if this congruence effect reflects feed-forward color priming of the target only; or if cue-elicited retrieval of color-specific task sets is involved. Crucially, we hypothesized that cue-based task-set retrieval should incur additional costs if the task sets for the two target colors differ more. In contrast, mere feed-forward priming should not be affected by task-set similarity between color-associated task sets. Congruence effects were indeed larger when color-associated task sets were more different. This finding indicates cue-elicited retrieval of color-associated task sets can contribute to effects of cue-target color congruence. Results are discussed in light of recent theories.
In the current review, we argue that experimental results usually interpreted as evidence for cognitive resource limitations could also reflect functional necessities of human information processing. ...First, we point out that selective processing of only specific features, objects, or locations at each moment in time allows humans to monitor the success and failure of their own overt actions and covert cognitive procedures. We then proceed to show how certain instances of selectivity are at odds with commonly assumed resource limitations. Next, we discuss examples of seemingly automatic, resource-free processing that challenge the resource view but can be easily understood from the functional perspective of monitoring cognitive procedures. Finally, we suggest that neurophysiological data supporting resource limitations might actually reflect mechanisms of how procedural control is implemented in the brain.
In Parkinson's disease, misfolded a-synuclein accumulates, often in a ubiquitinated form, in neuronal inclusions termed Lewy bodies. An important outstanding question is whether ubiquitination in ...Lewy bodies is directly relevant to a-synuclein trafficking or turnover and Parkinson's pathogenesis. By comparative analysis in human postmortem brains, we found that ubiquitin immunoreactivity in Lewy bodies is largely due to K63-linked ubiquitin chains and markedly reduced in the substantia nigra compared with the neocortex. The ubiquitin staining in cells with Lewy bodies inversely correlated with the content and pathological localization of the deubiquitinase Usp8. Usp8 interacted and partly colocalized with a-synuclein in endosomal membranes and, both in cells and after purification, it deubiquitinated K63-linked chains on a-synuclein. Knockdown of Usp8 in the Drosophila eye reduced a-synuclein levels and a-synuclein-induced eye toxicity. Accordingly, in human cells, Usp8 knockdown increased the lysosomal degradation of a-synuclein. In the dopaminergic neurons of the Drosophila model, unlike knockdown of other deubiquitinases, Usp8 protected from a-synuclein-induced locomotor deficits and cell loss. These findings strongly suggest that removal of K63-linked ubiquitin chains on a-synuclein by Usp8 is a critical mechanism that reduces its lysosomal degradation in dopaminergic neurons and may contribute to a-synuclein accumulation in Lewy body disease.
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