Drawing on theoretical work on humans’ adaptive capacity, we propose that supervisors’ perception of top management’s high bottom-line mentality (BLM) has a dysfunctional effect on their ethical ...leadership practices. Specifically, we suggest that these perceptions hinder supervisors’ empathy, which eventuates in less ethical leadership practices. We also investigate, in a first-stage moderated mediation model, how supervisors high in trait mindfulness are resistant to the ill effects of perceptions of top management’s high BLM. Supervisors high (versus low) in this trait are less likely to respond to perceptions of top management’s high BLM with reduced empathy that then hinders ethical leadership. Results from a multi-wave, multi-source sample of working adults from the Chinese high technology industry provide general support for our theoretical model. Theoretical and practical implications are discussed.
Does work politics get in the way of nurses’ passions even when mired in a global pandemic? To address this question, we examined the nonlinear associations of general work passion with job outcomes ...for practicing nurses and investigated whether these relationships were consistent across levels of perceived work politics. Results from multi-source, time-separated data indicated that passion possessed nonlinear associations with job satisfaction (inverted U-shape), work effort (U-shape), organizational citizenship behaviors (OCBs) (U-shape), and work performance (U-shape). Furthermore, passion demonstrated nonlinear relationships with job satisfaction and work effort when perceptions of organizational politics (POPs) were high (inverted U-shape) and low (U-shape). A nonlinear relationship emerged when POPs were high (inverted U-shape) when examining work passion associations with OCBs and job performance. Conversely, nonlinear associations were nonsignificant when POPs were low. These findings question the often-held assumption of linearity in the organizational sciences, in general, and support the speculation of more complex passion – outcome forms, specifically. We discuss implications of these results for nursing practice and scholarship, strengths, limitations, and avenues for future research.
Poor household water storage is one of the major factors contributing to contamination of drinking water in Nigeria. Studies have shown that sizes of containers opening can affect water quality, but ...little has been documented on comparative effect of storage containers with different opening sizes in improving drinking water quality in Ibadan. This study was designed to assess the effect of different storage containers on household drinking water quality in selected communities in Ibadan. A quasi-experimental design was adopted. Four communities in Ibadan North Local Government namely; Akewu using protected springs as household drinking water sources were purposively selected. Forty-four households (11 from each community) were selected and randomly assigned to four treatment groups; those with Covered Buckets with Taps (CBT), Covered Buckets without Tap (CB), Covered Kegs with Taps (CKT) and Covered Kegs without Tap (CK). Prior to introducing the treatment containers, water samples were collected from their Regular Storage Containers (RSC) and springs for physicochemical and bacteriological analysis using standard methods. Participants were thereafter encouraged to store drinking water in the treatment containers provided for them. Water samples were later collected from CBT, CB, CKT and CK containers twice daily for 3 alternate days over two weeks for bacteriological analysis. In addition, oldest female of selected households were interviewed using a pre-tested semi-structured questionnaire to elicit information on their socio-demographic characteristics, storage container cleaning and handwashing practices. Results of physicochemical and bacteriological findings were compared with Standard Organisation of Nigeria (SON) guidelines. Data were analysed using descriptive statistics, t- test and ANOVA at p=0.05. At baseline, mean pH values of water samples from the springs and RSC were 6.4±0.6 and 7.1±0.7 respectively compared with 6.5-8.5 limits recommended by SON. Mean chloride concentration of springs (14.3±7.4mg/l) and RSC (19.3±10.0 mg/l) samples were below 250mg/l limit recommended by SON. Mean Total Coliform Count (TCC) of the springs in the four communities was 18.0±4.0 and mean TCC of RSC was 12.7±4.9 which exceeded the SON standard of 10MPN/100ml. Five percent of water samples from RSC had mean E.coli count of 100/100ml compared with SON guidelines of 0/100ml. The mean TCC after introducing CB, CBT, CK and CKT in all the communities were 10.0±4.0, 8.5±4.2, 6.9±2.8 and 7.3±3.7 respectively (p<0.05). No E.coli was found in the samples collected from the treatment storage containers. The percentage difference of coliform count in water from springs and RSC was 29.4% while percentage difference from RSC and CB, CBT, CK and CKT were 21.5%, 33.2%, 45.5% and 42.5% respectively. Mean age of the 44 respondents interviewed was 37.9±10.7years. Seventy-three percent washed their hands with only water after defecation and 95.0% stored water for cooking and drinking in the same container. Sixty-eight percent cleaned their containers weekly while 32.0% cleaned twice weekly.
Family planning is fundamental to women's reproductive health and is a basic human right. Global targets such as Sustainable Development Goal 3 (specifically, Target 3.7) have been established to ...promote universal access to sexual and reproductive healthcare services. Country-level estimates of contraceptive use and other family planning indicators are already available and are used for tracking progress towards these goals. However, there is likely heterogeneity in these indicators within countries, and more local estimates can provide crucial additional information about progress towards these goals in specific populations. In this analysis, we develop estimates of six family indicators at a local scale, and use these estimates to describe heterogeneity and spatial-temporal patterns in these indicators in Burkina Faso, Kenya, and Nigeria.
We used a Bayesian geostatistical modelling framework to analyse geo-located data on contraceptive use and family planning from 61 household surveys in Burkina Faso, Kenya, and Nigeria in order to generate subnational estimates of prevalence and associated uncertainty for six indicators from 2000 to 2020: contraceptive prevalence rate (CPR), modern contraceptive prevalence rate (mCPR), traditional contraceptive prevalence rate (tCPR), unmet need for modern methods of contraception, met need for family planning with modern methods, and intention to use contraception. For each country and indicator, we generated estimates at an approximately 5 × 5-km resolution and at the first and second administrative levels (regions and provinces in Burkina Faso; counties and sub-counties in Kenya; and states and local government areas in Nigeria).
We found substantial variation among locations in Burkina Faso, Kenya, and Nigeria for each of the family planning indicators estimated. For example, estimated CPR in 2020 ranged from 13.2% (95% Uncertainty Interval, 8.0-20.0%) in Oudalan to 38.9% (30.1-48.6%) in Kadiogo among provinces in Burkina Faso; from 0.4% (0.0-1.9%) in Banissa to 76.3% (58.1-89.6%) in Makueni among sub-counties in Kenya; and from 0.9% (0.3-2.0%) in Yunusari to 31.8% (19.9-46.9%) in Somolu among local government areas in Nigeria. There were also considerable differences among locations in each country in the magnitude of change over time for any given indicator; however, in most cases, there was more consistency in the direction of that change: for example, CPR, mCPR, and met need for family planning with modern methods increased nationally in all three countries between 2000 and 2020, and similarly increased in all provinces of Burkina Faso, and in large majorities of sub-counties in Kenya and local government areas in Nigeria.
Despite substantial increases in contraceptive use, too many women still have an unmet need for modern methods of contraception. Moreover, country-level estimates of family planning indicators obscure important differences among locations within the same country. The modelling approach described here enables estimating family planning indicators at a subnational level and could be readily adapted to estimate subnational trends in family planning indicators in other countries. These estimates provide a tool for better understanding local needs and informing continued efforts to ensure universal access to sexual and reproductive healthcare services.
Objectives: Honey contains phenolic acids and flavonoids, which are significant in developing drugs against neuroinflammation. The study was designed to evaluate the ameliorative potential of honey ...in lipopolysaccharides-induced neuroinflammation.
Methods: Thirty male Wistar rats were divided into six groups, namely: the control group (10 mL/kg vehicle), the LPS only group (250 µg/kg), the honey (0.26, 0.31 and 0.36 g/kg) and the ibuprofen (100 mg/kg). LPS (250 µg/kg i.p) was administered for 7days followed by the treatment with honey and Ibuprofen for another 7days. Animals were assessed for memory impairment and anxiety levels using a Novel object recognition test (NORT), elevated plus maze (EPM), and open field test (OFT). Brain levels of pro-inflammatory cytokine level, acetylcholinesterase activity, and oxidative stress were determined. The neuronal alteration was assessed histologically using cresyl fast violet staining of the hippocampus, prefrontal cortex, and striatum.
Results: Honey (0.31 and 0.36 g/kg) significantly ameliorated LPS-induced memory impairment on NORT and increased time spent in the open arm and increased the locomotor activity in the OFT. Honey significantly (p < 0.05) reduced LPS-induced elevation of tumor necrosis factor (TNF-α) and interleukin-6 (IL-6). It significantly reduced malondialdehyde and nitrite levels in mice brains and reversed depletion of reduced glutathione levels. Honey attenuated LPS-induced elevation of acetylcholinesterase activity in rat brains. Cresyl violet staining showed the restoration of neuronal organization and Nissl body distribution in the hippocampus, prefrontal cortex and striatum compared to the LPS only group.
Discussion: Honey effectively ameliorated LPS-induced poor cognitive performance, anxiety, motor coordination responses to neuroinflammation, and oxidative stress.
The bacteria
Vibrio cholerae
causes cholera, an acute diarrheal infection that can lead to dehydration and even death. Over 100,000 people die each year as a result of epidemic diseases; vaccination ...has emerged as a successful strategy for combating cholera. This study uses bioinformatics tools to create a multi-epitope vaccine against cholera infection using five structural polyproteins from the
V. cholerae
(CTB, TCPA, TCPF, OMPU, and OMPW). The antigenic retrieved protein sequence were analyzed using BCPred and IEDB bioinformatics tools to predict B cell and T cell epitopes, respectively, which were then linked with flexible linkers together with an adjuvant to boost it immunogenicity. The construct has a theoretical PI of 6.09, a molecular weight of 53.85 kDa, and an estimated half-life for mammalian reticulocytes in vitro of 4.4 h. These results demonstrate the construct’s longevity. The vaccine design was docked against the human toll-like receptor (TLR) to evaluate compatibility and effectiveness; also other additional post-vaccination assessments were carried out on the designed vaccine. Through in silico cloning, its expression was determined. The results show that it has a CAI value of 0.1 and GC contents of 58.97% which established the adequate expression and downstream processing of the vaccine construct, and our research demonstrated that the multi-epitope subunit vaccine exhibits antigenic characteristics. Additionally, we carried out an in silico immunological simulation to examine the immune reaction to an injection. Our results strongly suggest that the vaccine candidate on further validation would induce immune response against the
V. cholerae
infection.
PurposeThis research assessed the interactive effects of employee passion and ego-resilience (ER) on relevant work outcomes, including job satisfaction, citizenship behavior, job tension, and ...emotional exhaustion. The authors hypothesize that higher work passion is associated with less positive work outcomes when employees are low in ER.Design/methodology/approachThe authors collected data from three unique samples (N's = 175, 141, 164) to evaluate the moderating effect across outcomes. The authors conducted analyses with and without demographic controls and affectivity (e.g. negative and positive). The authors used a time-separated data collection approach in Sample 3. The authors also empirically assess the potential for non-linear passion and ER main effect relationships to emerge.FindingsFindings across samples confirm that high passion employees with elevated levels of ER report positive attitudinal, behavioral, and well-being outcomes. Conversely, high passion employees do not experience comparable effects when reporting low levels of ER. Results were broadly consistent when considering demographics and affectivity.Research limitations/implicationsDespite the single-source nature of the three data collections, The authors took steps to minimize common method bias concerns (e.g. time separation and including affectivity). Future research will benefit from multiple data sources collected longitudinally and examining a more comprehensive range of occupational contexts.Practical implicationsPassion is something that organizations want in all employees. However, the authors' results show that passion may not be enough to lead to favorable outcomes without considering factors that support its efficacy. Also, results show that moderate levels of passion may offer little benefit compared to low levels and may be detrimental.Originality/valueAs a focal research topic, work passion research is still in early development. Studies exploring factors that support or derail expected favorable effects of work passion are needed to establish a foundation for subsequent analyses. Moreover, the authors comment on the assumed “more is better” phenomenon. The authors argue for reconsidering the linear approach to predicting behavior in science and practice.
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