The aim of the study was to report on a case of isolated spontaneous fracture of the genial tubercles, an uncommon pathological condition, the onset of which may be associated with non‐specific but ...potentially life‐threatening signs and symptoms, such as haematoma or swelling of the oral floor. We conducted a literature review to identify similar cases, focusing on their diagnosis, management and causes. To date, only 15 cases of spontaneous genial tubercle fracture have been described in 14 reports in the English medical literature. Patients were mainly female, with a mean age of 70 years. Only 5/15 cases (33%) were managed surgically, the others (66%) conservatively. A full functional recovery of the tongue movements, swallowing and talking is achievable with conservative therapy in most cases, but surgery is indicated for patients with persistent dysfunction or clinical discomfort. The case described here was treated conservatively, consistently with the literature, with active observation, corticosteroids and prophylactic i.v. antibiotic therapy leading to a complete recovery within a few weeks. Though extremely uncommon, genial tubercle fracture should be included in the differential diagnosis of haematoma and swelling of the oral floor. It is potentially life‐threatening, requiring active monitoring and careful airway management. Conservative procedures and a long‐term follow‐up are needed to control possible functional restrictions and symptoms, and surgical treatment should be considered in refractory cases.
Yersinia enterocolitica is recognized as an etiological agent of gastroenteritis, lymphadenitis, and chronic sequelae. During 2006 and 2007, 205 samples (125 pork and 80 chicken meats) were collected ...in Italy and tested for detection and most-probable-number (MPN) enumeration of Y. enterocolitica organisms. The microorganism was isolated from 45 samples (21.9%): 19 (15.2%) pork samples and 26 (32.5%) chicken samples. Y. enterocolitica MPN contamination levels were low, ranging from 0.30 to 1.50/g. Most (94.4%) Y. enterocolitica strains were biotype 1A (serotypes O:3; O:5; O:6,30; O:6,30-6,31; O:7,8-8-8,19; O:8; O:9; O:25,35; O:36; and O nontypeable), and 5.6% of the isolates were bioserotype 2/O:9. All isolates were tested for yadA, ail, inv, ystA, and ystB virulence sequences. The yadA gene was detected in two strains (3.7%) isolated from chicken samples: one Y. enterocolitica 2/O:9 yadA+ ail+ ystA+, and one Y. enterocolitica 1A/O:7,8-8-8,19 yadA+ inv+ ystB+. Two (3.7%) 2/O:9 strains, isolated from pork products, were ail+ ystA+. Most biotype 1A strains were ystB+ (84.3%) and inv+ (39.2%). All strains were sensitive to cefotaxime, ciprofloxacin, chloramphenicol, nalidixic acid, streptomycin, sulfonamide, tetracycline, trimethoprim, and trimethoprim-sulfamethoxazole. Resistance to gentamicin and aztreonam was observed in 1.9% of the isolates. High levels of resistance were detected toward amoxicillin-clavulanic acid (27.8%), ampicillin (75.9%), and erythromycin (100%). The authors hypothesize that Y. enterocolitica pathogenic biotypes are rather uncommon in foods when compared with their isolation rates from animal sources and that chicken meat could be contaminated as well as pig meat and its derived products.
The ARGO-YBJ experiment is mainly devoted to search for astronomical gamma sources. The arrival direction of air showers is reconstructed thanks to the times measured by the pixels of the detector. ...Therefore, the timing calibration of the detector pixels is crucial in order to get the best angular resolution and pointing accuracy. Because of the large number of pixels a hardware timing calibration is practically impossible. Therefore an off-line software calibration has been adopted. Here, the details of the procedure and the results are presented.
Bacci C, Sestini R, Ammannati F, Bianchini E, Palladino T, Carella M, Melchionda S, Zelante L, Papi L. Multiple spinal ganglioneuromas in a patient harboring a pathogenic NF1 mutation.
Ganglioneuroma ...is a rare benign tumor originating from autonomic ganglia and is considered the benign counterpart of neuroblastoma. Ganglioneuromas may be present as an isolated finding and, rarely, in association with neurofibromatosis type 1 (NF1). However, ganglioneuromas of the cervical spine with intradural extension and multiple locations are extremely rare. We describe a 32‐year‐old woman with multiple ganglioneuromas of the cervical, dorsal and lumbar spine associated with a few café‐au‐lait spots and subcutaneous nodules. The patient lacked other NF1 stigmata, such as freckling, Lisch nodules and cutaneous neurofibromas. Although our patient did not fulfill the NF1 diagnostic criteria, molecular diagnosis revealed a pathogenic mutation in the NF1 gene. Approximately 30 patients affected by NF1 and ganglioneuromas have been reported: in all these individuals, NF1 diagnosis was made according to the clinical diagnostic criteria and no patients have molecular diagnosis. Therefore, this is the first case with multiple spinal ganglioneuromas associated with a pathogenic NF1 mutation.
Introduction Ruminants are regarded as the natural reservoir for Shiga toxin-producing Escherichia coli (STEC), especially of serogroup O157. Materials and methods During 2011 and 2012, 320 samples ...(160 faecal samples from the rectum and 160 hide samples from the brisket area) were collected from 160 cattle at slaughter in Northern Italy during warm months (May to October). Cattle were reared in different farms and their age at slaughter ranged between nine months and 15 years, most of them being culled cattle (median age: six years; average age: 4.6 years). Samples were tested by immunomagnetic-separation technique for E coli O157 and O26 and by a screening PCR for stx genes followed by cultural detection of STEC. The virulence genes stx1, stx2, eae, and e-hlyA were detected and among stx2-positive isolates the presence of the stx2a and stx2c variants was investigated. Results Twenty-one of 160 cattle (13.1 per cent; 95 per cent CI 8.3 to 19.4 per cent) were found to be faecal carriers of STEC. STEC O157 was found in 10 (6.3 per cent) samples, STEC O26 in six (3.8 per cent) and STEC O111 in one (0.6 per cent). Four isolates (2.5 per cent) were O not determined (OND). Six out of 160 (3.8 per cent; 95 per cent CI 1.4 to 8.0 per cent) hide samples were positive for STEC; four hides (2.5 per cent) were contaminated by STEC O157 and two (1.3 per cent) by STEC O26. In three cattle (1.9 per cent) STEC from both faeces and hides were detected. Among STEC O157, 87.5 per cent of them carried the stx2c gene and 12.5 per cent carried both stx1 and stx2c genes. No O157 isolate harboured stx2a variant. STEC O26 and O111 carried the stx1 gene only. One OND strain carried both the stx2a and stx2c genes. Conclusions This study shows that STEC O157 from cattle can harbour the stx2c variant, which is associated with haemolytic uraemic syndrome in humans, and that cattle hides may be a source of human pathogenic STEC O157 and O26 in the slaughterhouse environment.
The effects of hypnosis dental pain threshold Facco, E; Casiglia, E; Zanette, G ...
International journal of oral and maxillofacial surgery,
2011, Volume:
40, Issue:
10
Journal Article
We report the GALLEX solar neutrino results for the measuring period GALLEX III, the period from 12 October 1994-4 October 1995. Counting for these runs was completed on 29 March 1996. The GALLEX III ...result (14 runs) is 53.9 ± 10.6(stat.) ± 3.1 (syst.) SNU (1σ). This is 15.8 SNU below but statistically compatible with the new combined result for GALLEX (I+II+III) (53 runs), which is 69.7 ± 6.7(stat.)
−4.5
+3.9(syst.) SNU (1σ) or (69.7
−8.1
+7.8) SNU with errors quadratically added. We also give the preliminary result from our second
51Cr-source experiment: the measured detector response is 83±10% of expectation. The combined result from both GALLEX
51Cr-source experiments is 92±8% of expectation.
The aim of the study was to evaluate the sensitivity of two m-PCR methods for the quantitative determination of E. coli O157:H7 in foodstuffs. Genomic serotyping was carried out on bacterial ...cultures, and the necessary time was optimized to increase the resolution of the method. Subsequently, artificial contamination trials using meat were conducted to assess method accuracy in foodstuffs and pursue the genetic typing of pathogens. Measurement thresholds were shown to range between 10⁵ and 10⁶ CFU/mL, but were reduced by four logarithmic cycles in 80% of samples. Relative to the meat contamination trials, serotypes were identified after 24 hours, corresponding to 10 CFU/mL inoculum, with higher rates seen when m-TSB was used for enrichment. Inoculated samples were found to contain three virulence factors (hlyA, eaeA, and stx1).
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