Abstract Aseptic loosening of the tibial component remains a major cause of failure in total knee arthroplasty and may be related, directly or indirectly, to micromotion. Therefore, good fixation of ...the tibial component is a prerequisite to achieve long-term success of the implant. Cementing technique is one of the factors that play a role in this respect. We investigated the effect of different cementing techniques on the cement penetration in the proximal tibia. We compared 5 different cementing techniques in an anatomical open pore sawbone model (n = 25), using a contemporary total knee arthroplasty design and standard polymethylmetacrylate cement. We demonstrated that applying cement to both the undersurface of the tibial baseplate and as well as onto the tibial bone, either by a spatula or fingerpacking technique, leads to an optimal cement penetration of 3 to 5 mm. When cement is applied only onto the tibial component, penetration is insufficient. When a cement gun is used, cement penetration is too excessive.
Osteoarthritis is a common musculoskeletal disorder. Classification models can discriminate an osteoarthritic gait pattern from that of control subjects. However, whether the output of learned models ...(probability of belonging to a class) is usable for monitoring a person's functional recovery status post-total knee arthroplasty (TKA) is largely unexplored. The research question is two-fold: (I) Can a learned classification model's output be used to monitor a person's recovery status post-TKA? (II) Is the output related to patient-reported functioning? We constructed a logistic regression model based on (1) pre-operative IMU-data of level walking, ascending, and descending stairs and (2) 6-week post-operative data of walking, ascending-, and descending stairs. Trained models were deployed on subjects at three, six, and 12 months post-TKA. Patient-reported functioning was assessed by the KOOS-ADL section. We found that the model trained on 6-weeks post-TKA walking data showed a decrease in the probability of belonging to the TKA class over time, with moderate to strong correlations between the model's output and patient-reported functioning. Thus, the LR-model's output can be used as a screening tool to follow-up a person's recovery status post-TKA. Person-specific relationships between the probabilities and patient-reported functioning show that the recovery process varies, favouring individual approaches in rehabilitation.
Purpose To characterize the tensile and histologic properties of the anterolateral ligament (ALL), inferior glenohumeral ligament (IGHL), and knee capsule. Methods Standardized samples of the ALL ...(n = 19), anterolateral knee capsule (n = 15), and IGHL (n = 13) were isolated from fresh-frozen human cadavers for uniaxial tensile testing to failure. An additional 6 samples of the ALL, capsule, and IGHL were procured for histologic analysis and determination of elastin content. Results All investigated mechanical properties were significantly greater for both the ALL and IGHL when compared with capsular tissue. In contrast, no significant differences between the ALL and IGHL were found for any property. The elastic modulus of ALL and IGHL samples was 174 ± 92 MPa and 139 ± 60 MPa, respectively, compared with 62 ± 30 MPa for the capsule ( P = .001). Ultimate stress was significantly lower ( P < .001) for the capsule, at 13.4 ± 7.7 MPa, relative to the ALL and IGHL, at 46.4 ± 20.1 MPa and 38.7 ± 16.3 MPa, respectively. The ultimate strain at failure was 37.8% ± 7.9% for the ALL and 39.5% ± 9.4% for the IGHL; this was significantly greater ( P = .041 and P = .02, respectively) for both relative to the capsule, at 32.6% ± 8.4%. The strain energy density was 7.8 ± 3.1 MPa for the ALL, 2.1 ± 1.3 MPa for the capsule, and 7.1 ± 3.1 MPa for the IGHL ( P < .001). The ALL and IGHL consisted of collagen bundles aligned in a parallel manner, containing elastin bundles, which was in contrast to the random collagen architecture noted in capsule samples. Conclusions The ALL has similar tensile and histologic properties to the IGHL. The tensile properties of the ALL are significantly greater than those observed in the knee capsule. Clinical Relevance The ALL is not just a thickening of capsular tissue and should be considered a distinct ligamentous structure comparable to the IGHL in the shoulder. The tensile behavior of the ALL is similar to the IGHL, and treatment strategies should take this into account.
The aim of this study was to provide information about the mechanical properties of grafts used for knee ligament reconstructions and to compare those results with the mechanical properties of native ...knee ligaments.
Eleven cadaveric knees were dissected for the semitendinosus, gracilis, iliotibial band (ITB), quadriceps and patellar tendon. Uniaxial testing to failure was performed using a standardized method and mechanical properties (elastic modulus, ultimate stress, ultimate strain, strain energy density) were determined.
The elastic modulus of the gracilis tendon (1458±476MPa) (P<0.001) and the semitendinosus tendon (1036±312MPa) (P<0.05) was significantly higher than the ITB (610±171MPa), quadriceps tendon (568±194MPa), and patellar tendon (417±107MPa). In addition, the ultimate stress of the hamstring tendons (gracilis 155.0±30.7MPa and semitendinosus 120.1±30.0MPa) was significantly higher (P<0.001, respectively P<0.05), relative to the ITB (75.0±11.8MPa), quadriceps tendon (81.0±27.6MPa), and patellar tendon (76.2±25.1MPa). A significant difference (P<0.05) could be noticed between the ultimate strain of the patellar tendon (24.6±5.9%) and the hamstrings (gracilis 14.5±3.1% and semitendinosus 17.0±4.0%). No significant difference in strain energy density between the grafts was observed.
Material properties of common grafts used for knee ligament reconstructions often differ significantly from the original knee ligament which the graft is supposed to emulate.
IntroductionThe prevalence of chronic knee pain is increasing. Osteoarthritis (OA) and persistent postsurgical pain (PPSP) are two important causes of knee pain. Chronic knee pain is primarily ...treated with medications, physiotherapy, life-style changes and intra-articular infiltrations. A radiofrequency treatment (RF) of the genicular nerves is a therapeutical option for refractory knee pain. This study investigates the effectiveness and cost-effectiveness of conventional and cooled RF in patients suffering from chronic, therapy resistant, moderate to severe knee pain due to OA and PPSP.Methods and analysisThe COGENIUS trial is a double-blinded, randomised controlled trial with 2-year follow-up. Patients and outcome assessors are blinded. Patients will be recruited and treated in Belgium and the Netherlands. All PPSP after a total knee prothesis and OA patients (grades 2–4) will undergo a run-in period of 1–3 months where conservative treatment will be optimised. After the run-in period, 200 patient per group will be randomised to conventional RF, cooled RF or a sham procedure following a 2:2:1 ratio. The analysis will include a comparison of the effectiveness of each RF treatment with the sham procedure and secondarily between conventional and cooled RF. All comparisons will be made for each indication separately. The primary outcome is the Western Ontario and McMaster Universities Osteoarthritis Index score at 6 months. Other outcomes include knee pain, physical functionality, health-related quality of life, emotional health, medication use, healthcare and societal cost and adverse events up to 24 months postintervention.Ethics and disseminationEthics approval was obtained from the Ethics Committee of the University of Antwerp (Number Project ID 3069-Edge 002190-BUN B3002022000025), the Ethics committee of Maastricht University (Number NL80503.068.22-METC22-023) and the Ethics committee of all participating hospitals. Results of the study will be published in international peer-reviewed journals.Trial registration numberNCT05407610.
Purpose: The aim of this study was to identify the anatomic relation between the posterolateral drill hole and the lateral structures of the knee. The length of the posterolateral tunnel and the ...feasibility of the EndoButton CL (Smith & Nephew, Andover, MA) as posterolateral graft fixation device was also evaluated. Methods: An anatomic descriptive study was performed on 24 cadaveric knees. The double-bundle anterior cruciate ligament (ACL) was reconstructed using standard arthroscopic techniques and the EndoButton CL fixation system. The study protocol was as follows: first, an arthroscopy with posterolateral pin placement and drilling of the posterolateral tunnel was performed. Subsequently, the lateral structures were dissected and the distance between the pin and the different anatomic structures was measured. From outside in, the length of the posterolateral tunnel was also measured. Results: This study shows that there is no increased risk of injuring the lateral collateral ligament during posterolateral tunnel placement in double-bundle ACL reconstruction, when performed through a low anteromedial portal in high flexion. Furthermore, a safe margin was noted between the posterolateral tunnel and the adjacent lateral gastrocnemius and popliteus tendons. The length of the posterolateral tunnel was between 32 and 44 mm (mean, 36.92 mm). Conclusions: We conclude that the posterolateral tunnel can be created safely in double-bundle ACL reconstruction without additional risk to the surrounding structures. A 15-mm EndoButton CL fixation device is routinely advised as posterolateral graft fixation in order to avoid the risk of over-advancing the device or overdrilling. Clinical Relevance: This study has shown that there is no risk of iatrogenic lesion to the lateral collateral ligament, lateral gastrocnemius tendon, or popliteus tendon with a posterolateral tunnel drilled through a low anteromedial portal in high flexion.
Apart from biomechanical alterations in movement patterns, it is known that movement limitations in persons with knee osteoarthritis (PwKOA) are related to an individual's perception and belief ...regarding pain and disability. To gain more insights into the functional movement behaviour of PwKOA in a clinical setting, inertial sensor technology can be applied. This study first aims to evaluate the ability of inertial sensors to discriminate between healthy controls (HC) and PwKOA. Secondly, this study aims to determine the relationship between movement behaviour, pain-related factors and disability scores.
Twelve HC and 19 PwKOA were included. Five repetitions of six functional movement tasks (walking, forward lunge, sideward lunge, ascent and descent stairs, single leg squat and sit-to-stand) were simultaneously recorded by the inertial sensor system and a camera-based motion analysis system. Statistically significant differences in angular waveforms of the trunk, pelvis and lower limb joints between HC and PwKOA were determined using one-dimensional statistical parametric mapping (SPM1D). The Knee injury and Osteoarthritis Outcome Score and TAMPA scale for Kinesiophobia were used to evaluate the relationship between discriminating joint motion, pain-related factors and disability using spearman's correlation coefficients.
PwKOA had significantly less trunk rotation, internal pelvis rotation and knee flexion ROM during walking. Additionally, the reduced knee flexion (i.e. at the end of the stance phase and swing phase) was related to increased level of perceived pain. During the sideward lunge, PwKOA had significantly less knee flexion, ankle plantarflexion and hip abduction. This decreased hip abduction (i.e. during stance) was related to higher fear of movement. Finally, PwKOA had significantly less knee flexion during the forward lunge, single leg squat and during ascent and descent stairs. No significant correlations were observed with disability.
Inertial sensors were able to discriminate between movement characteristics of PwKOA and HC. Additionally, significant relationships were found between joint motion, perceived pain and fear of movement. Since inertial sensors can be used outside the laboratory setting, these results are promising as they indicate the ability to evaluate movement deviations. Further research is required to enable measurements of small movement deviations in clinically relevant tasks.
The pathology of medial tibial stress syndrome (MTSS) is unknown. Studies suggest that MTSS is a bony overload injury, but histological evidence is sparse. The presence of microdamage, and its ...potential association with targeted remodeling, could provide evidence for the pathogenesis of MTSS. Understanding the pathology underlying MTSS could contribute to effective preventative and therapeutic interventions for MTSS. Our aim was to retrospectively evaluate biopsies, previously taken from the painful area in athletes with MTSS, for the presence of linear microcracks, diffuse microdamage and remodeling. Biopsies, previously taken from athletes with MTSS, were evaluated at the Department of Anatomy and Cell Biology at the Indiana University. After preparing the specimens by en bloc staining, one investigator evaluated the presence of linear microcracks, diffuse microdamage and remodeling in the specimens. A total of six biopsies were evaluated for the presence of microdamage and remodeling. Linear microcracks were found in 4 out of 6 biopsies. Cracking in one of these specimens was artefactual due to the biopsy procedure. No diffuse microdamage was seen in any of the specimens, and only one potential remodeling front in association with the microcracks. We found only linear microcracks in vivo in biopsies taken from the painful area in 50% of the athletes with MTSS, consistent with the relationship between linear cracks and fatigue-associated overloading of bone. The nearly universal absence of a repair reaction was notable. This suggests that unrepaired microdamage accumulation may underlie the pathophysiological basis for MTSS in athletes.
Most surgeons believe that varus deformity leads to progressive tightness of the medial soft tissue envelope and laxity on the lateral side. It is, however, unclear at what stage of the deformity ...such ligament alterations occur, and whether these are the consequence of intrinsic alterations in the ligaments themselves, or rather due to extrinsic factors such as osteophytes, adhesions to the underlying bone, or other factors which may cause a tightening effect. Thirty-five varus knees that were scheduled for TKA were investigated. Ligament status was evaluated after temporary correction of alignment and removal of osteophytes, using varus/valgus testing with computer navigation technology. Knees with <10° varus deformity were easily correctable to neutral after correction of the extrinsic factors that could cause medial tightness, and these knees maintained normal mediolateral laxity during varus/valgus stress testing. When coronal plane deformity exceeded 10°, progressive shortening of the medial collateral ligament was noted, as well as progressive stretching of the lateral structures (
P
< 0.001). This study, therefore, demonstrates that the medial collateral structures become intrinsically shortened when preoperative varus deformity exceeds 10°. Likewise, the lateral soft tissues become stretched. None of these occur when the preoperative deformity is <10°.
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