People find it easier to learn about topics that interest them, but little is known about the mechanisms by which intrinsic motivational states affect learning. We used functional magnetic resonance ...imaging to investigate how curiosity (intrinsic motivation to learn) influences memory. In both immediate and one-day-delayed memory tests, participants showed improved memory for information that they were curious about and for incidental material learned during states of high curiosity. Functional magnetic resonance imaging results revealed that activity in the midbrain and the nucleus accumbens was enhanced during states of high curiosity. Importantly, individual variability in curiosity-driven memory benefits for incidental material was supported by anticipatory activity in the midbrain and hippocampus and by functional connectivity between these regions. These findings suggest a link between the mechanisms supporting extrinsic reward motivation and intrinsic curiosity and highlight the importance of stimulating curiosity to create more effective learning experiences.
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•People are better at learning information that they are curious about•Memory for incidental material presented during curious states was also enhanced•Curiosity associated with anticipatory activity in nucleus accumbens and midbrain•Memory benefits for incidental material depend on midbrain-hippocampus involvement
Real-life learning is often motivated by intrinsic curiosity. Gruber et al. demonstrate that learning is enhanced during states of high curiosity, both for interesting material and for incidental, unrelated material. These memory benefits depended on midbrain-hippocampus interactions.
Among the great ironies of quantum mechanics is not only that its conceptual foundations seem strange even to the physicists who use it, but that philosophers have largely ignored it. Here, Bernard ...d'Espagnat argues that quantum physics--by casting doubts on once hallowed concepts such as space, material objects, and causality-demands serious reconsideration of most of traditional philosophy. On Physics and Philosophy is an accessible, mathematics-free reflection on the philosophical meaning of the quantum revolution, by one of the world's leading authorities on the subject. D'Espagnat presents an objective account of the main guiding principles of contemporary physics-in particular, quantum mechanics-followed by a look at just what consequences these should imply for philosophical thinking. The author begins by describing recent discoveries in quantum physics such as nonseparability, and explicating the significance of contemporary developments such as decoherence. Then he proceeds to set various philosophical theories of knowledge--such as materialism, realism, Kantism, and neo-Kantism--against the conceptual problems quantum theory raises. His overall conclusion is that while the physical implications of quantum theory suggest that scientific knowledge will never truly describe mind-independent reality, the notion of such an ultimate reality--one we can never access directly or rationally and which he calls "veiled reality"--remains conceptually necessary nonetheless.
Infective endocarditis Cahill, Thomas J, MRCP; Prendergast, Bernard D, Dr
The Lancet (British edition),
02/2016, Volume:
387, Issue:
10021
Journal Article
Peer reviewed
Open access
Summary Infective endocarditis occurs worldwide, and is defined by infection of a native or prosthetic heart valve, the endocardial surface, or an indwelling cardiac device. The causes and ...epidemiology of the disease have evolved in recent decades with a doubling of the average patient age and an increased prevalence in patients with indwelling cardiac devices. The microbiology of the disease has also changed, and staphylococci, most often associated with health-care contact and invasive procedures, have overtaken streptococci as the most common cause of the disease. Although novel diagnostic and therapeutic strategies have emerged, 1 year mortality has not improved and remains at 30%, which is worse than for many cancers. Logistical barriers and an absence of randomised trials hinder clinical management, and longstanding controversies such as use of antibiotic prophylaxis remain unresolved. In this Seminar, we discuss clinical practice, controversies, and strategies needed to target this potentially devastating disease.
Abstract
Background
Globally, access to healthcare and diagnostic technologies are known to substantially impact the reported birth prevalence of congenital heart disease (CHD). Previous studies have ...shown marked heterogeneity between different regions, with a suggestion that CHD prevalence is rising globally, but the degree to which this reflects differences due to environmental or genetic risk factors, as opposed to improved detection, is uncertain. We performed an updated systematic review to address these issues.
Methods
Studies reporting the birth prevalence of CHD between the years 1970–2017 were identified from searches of PubMed, EMBASE, Web of Science and Google Scholar. Data on the prevalence of total CHD and 27 anatomical subtypes of CHD were collected. Data were combined using random-effect models. Subgroup and meta-regression analyses were conducted, focused on geographical regions and levels of national income.
Results
Two hundred and sixty studies met the inclusion criteria, encompassing 130 758 851 live births. The birth prevalence of CHD from 1970–2017 progressively increased to a maximum in the period 2010–17 of 9.410/1000 95% CI (confidence interval) 8.602–10.253. This represented a significant increase over the fifteen prior years (P = 0.031). The change in prevalence of mild CHD lesions (ventricular septal defect, atrial septal defect and patent ductus arteriosus) together explained 93.4% of the increased overall prevalence, consistent with a major role of improved postnatal detection of less severe lesions. In contrast the prevalence of lesions grouped together as left ventricular outflow tract obstruction (which includes hypoplastic left heart syndrome) decreased from 0.689/1000 (95% CI 0.607–0.776) in 1995–99, to 0.475/1000 (95% CI 0.392–0.565; P = 0.004) in 2010–17, which would be consistent with improved prenatal detection and consequent termination of pregnancy when these very severe lesions are discovered. There was marked heterogeneity among geographical regions, with Africa reporting the lowest prevalence 2.315/1000 (95% CI 0.429–5.696) and Asia the highest 9.342/1000 (95% CI 8.072–10.704).
Conclusions
The reported prevalence of CHD globally continues to increase, with evidence of severe unmet diagnostic need in Africa. The recent prevalence of CHD in Asia for the first time appears higher than in Europe and America, where disease ascertainment is likely to be near-complete, suggesting higher genetic or environmental susceptibility to CHD among Asian people.
Challenges in Infective Endocarditis Cahill, Thomas J., MBBS; Baddour, Larry M., MD; Habib, Gilbert, MD ...
Journal of the American College of Cardiology,
01/2017, Volume:
69, Issue:
3
Journal Article
Peer reviewed
Open access
Abstract Infective endocarditis is defined by a focus of infection within the heart and is a feared disease across the field of cardiology. It is frequently acquired in the health care setting, and ...more than one-half of cases now occur in patients without known heart disease. Despite optimal care, mortality approaches 30% at 1 year. The challenges posed by infective endocarditis are significant. It is heterogeneous in etiology, clinical manifestations, and course. Staphylococcus aureus , which has become the predominant causative organism in the developed world, leads to an aggressive form of the disease, often in vulnerable or elderly patient populations. There is a lack of research infrastructure and funding, with few randomized controlled trials to guide practice. Longstanding controversies such as the timing of surgery or the role of antibiotic prophylaxis have not been resolved. The present article reviews the challenges posed by infective endocarditis and outlines current and future strategies to limit its impact.
The rapid increase in unconventional natural gas (UNG) development in the United States during the past decade has brought wells and related infrastructure closer to population centers. This review ...evaluates risks to public health from chemical and nonchemical stressors associated with UNG, describes likely exposure pathways and potential health effects, and identifies major uncertainties to address with future research. The most important occupational stressors include mortality, exposure to hazardous materials and increased risk of industrial accidents. For communities near development and production sites the major stressors are air pollutants, ground and surface water contamination, truck traffic and noise pollution, accidents and malfunctions, and psychosocial stress associated with community change. Despite broad public concern, no comprehensive population-based studies of the public health effects of UNG operations exist. Major uncertainties are the unknown frequency and duration of human exposure, future extent of development, potential emission control and mitigation strategies, and a paucity of baseline data to enable substantive before and after comparisons for affected populations and environmental media. Overall, the current literature suggests that research needs to address these uncertainties before we can reasonably quantify the likelihood of occurrence or magnitude of adverse health effects associated with UNG production in workers and communities.
Saharan silver ants, Cataglyphis bombycina, forage under extreme temperature conditions in the African desert. We show that the ants' conspicuous silvery appearance is created by a dense array of ...triangular hairs with two thermoregulatory effects. They enhance not only the reflectivity of the ant's body surface in the visible and near-infrared range of the spectrum, where solar radiation culminates, but also the emissivity of the ant in the mid-infrared. The latter effect enables the animals to efficiently dissipate heat back to the surroundings via blackbody radiation under full daylight conditions. This biological solution for a thermoregulatory problem may lead to the development of biomimetic coatings for passive radiative cooling of objects.
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