The Greenland ice sheet is experiencing increasing rates of mass loss, the majority of which results from changes in discharge from tidewater glaciers. Both atmospheric and ocean drivers have been ...implicated in these dynamic changes, but understanding the nature of the response has been hampered by the lack of measurements of glacier flow rates predating the recent period of warming. Here, using Landsat-5 data from 1985 onwards, we extend back in time the record of surface velocities and ice-front position for 16 of Greenland's fastest-flowing tidewater glaciers, and compare these to more recent data from Landsat-7 and satellite-borne synthetic-aperture radar. Climate re-analysis data and sea surface temperatures from 1982 show that since 1995 most of Greenland and its surrounding oceans have experienced significant overall warming, and a switch to a warming trend. During the period from 1985 to 1995 when Greenland and the surrounding oceans were not warming, major tidewater outlet glaciers around Greenland, including Kangerdlugssuaq and Helheim, were dynamically stable. Since the mid-1990s, glacier discharge has consistently been both greater and more variable. Together, these observations support the hypothesis that recent dynamic change is a rapid response to climate forcing. Both air and ocean temperatures in this region are predicted to continue to warm, and will therefore likely drive further change in outlet glacier discharge.
Overall mass loss from the Greenland ice sheet nearly doubled during the early 2000s resulting in an increased contribution to sea-level rise, with this step-change being mainly attributed to the ...widespread frontal retreat and accompanying dynamic thinning of tidewater glaciers. Changes in glacier calving-front positions are easily derived from remotely sensed imagery and provide a record of dynamic change. However, ice-sheet-wide studies of calving fronts have been either spatially or temporally limited. In this study multiple calving-front positions were derived for 199 Greenland marine-terminating outlet glaciers with width greater than 1 km using Landsat imagery for the 11-year period 2000–2010 in order to identify regional seasonal and inter-annual variations. During this period, outlet glaciers were characterized by sustained and substantial retreat summing to more than 267 km, with only 11 glaciers showing overall advance. In general, the pattern of mass loss detected by GRACE (Gravity Recovery and Climate Experiment) and other measurements is reflected in the calving record of Greenland glaciers. Our results suggest several regions in the south and east of the ice sheet likely share controls on their dynamic changes, but no simple single control is apparent.
Many scenarios of physics beyond the standard model predict the existence of new gauge singlets, which might be substantially lighter than the weak scale. The experimental constraints on additional ...scalars with masses in the MeV to GeV range could be significantly weakened if they interact predominantly with leptons rather than quarks. At an e+e− collider, such a leptophilic scalar (ϕL) would be produced predominantly through radiation from a τ lepton. We report herein a search for e+e−→τ+τ−ϕL, ϕL→ℓ+ℓ− (ℓ=e, μ) using data collected by the BABAR experiment at SLAC. No significant signal is observed, and we set limits on the ϕL coupling to leptons in the range 0.04<mϕL<7.0 GeV. These bounds significantly improve upon the current constraints, excluding almost entirely the parameter space favored by the observed discrepancy in the muon anomalous magnetic moment below 4 GeV at 90% confidence level.
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Disability measures in multiple sclerosis (MS) rely heavily on ambulatory function, and current metrics fail to capture potentially important variability in walking behavior. We sought to determine ...whether remote step count monitoring using a consumer-friendly accelerometer (Fitbit Flex) can enhance MS disability assessment. 99 adults with relapsing or progressive MS able to walk ≥2-min were prospectively recruited. At 4 weeks, study retention was 97% and median Fitbit use was 97% of days. Substudy validation resulted in high interclass correlations between Fitbit, ActiGraph and manual step count tally during a 2-minute walk test, and between Fitbit and ActiGraph (ICC = 0.76) during 7-day home monitoring. Over 4 weeks of continuous monitoring, daily steps were lower in progressive versus relapsing MS (mean difference 2546 steps,
p
< 0.01). Lower average daily step count was associated with greater disability on the Expanded Disability Status Scale (EDSS) (
p
< 0.001). Within each EDSS category, substantial variability in step count was apparent (i.e., EDSS = 6.0 range 1097–7152). Step count demonstrated moderate-strong correlations with other walking measures. Lower average daily step count is associated with greater MS disability and captures important variability in real-world walking activity otherwise masked by standard disability scales, including the EDSS. These results support remote step count monitoring as an exploratory outcome in MS trials.
The occurrence of surface melt in Antarctica has hitherto been associated with the austral summer season, when the dominant source of melt energy is provided by solar radiation. We use in situ and ...satellite observations from a previously unsurveyed region to show that events of intense surface melt on Larsen C Ice Shelf occur frequently throughout the dark Antarctic winter, with peak intensities sometimes exceeding summertime values. A regional atmospheric model confirms that in the absence of solar radiation, these multiday melt events are driven by outbreaks of warm and dry föhn wind descending down the leeside of the Antarctic Peninsula mountain range, resulting in downward turbulent fluxes of sensible heat that drive sustained surface melt fluxes in excess of 200 W/m2. From 2015 to 2017 (including the extreme melt winter of 2016), ∼23% of the annual melt flux was produced in winter, and spaceborne observations of surface melt since 2000 show that wintertime melt is widespread in some years. Winter melt heats the firn layer to the melting point up to a depth of ∼3 m, thereby facilitating the formation of impenetrable ice layers and retarding or reversing autumn and winter cooling of the firn. While the absence of a trend in winter melt is consistent with insignificant changes in the observed Southern Hemisphere atmospheric circulation during winter, we anticipate an increase in winter melt as a response to increasing greenhouse gas concentration.
Plain Language Summary
Around the coast of Antarctica, it gets warm enough in summer for snow to start melting, and the sun provides most of the energy for that melt. Almost all meltwater refreezes in the snowpack, but especially on floating glaciers in Antarctica, it has been observed that meltwater forms large ponds. The pressure exerted by these ponds may have led to ice shelves collapsing into numerous icebergs in recent decades. It is therefore important to understand how much meltwater is formed. To find out, we installed an automatic weather station on a glacier in Cabinet Inlet, in the Antarctic Peninsula in 2014. The station recorded temperatures well above the melting point even in winter. The occurrence of winter melt is confirmed by satellite images and by thermometers buried in the snow, which measured a warming of the snow even at 3 m depth. Between 2014 and 2017, about 23% of all melt in Cabinet Inlet occurred in winter. Winter melt is due to warm winds that descend from the mountains, known as föhn. We have not seen the amount of winter melt increasing since 2000. However, we expect winter melt to happen more frequently if greenhouse gas continues to accumulate in the atmosphere.
Key Points
Wintertime surface melt occurs frequently in the Antarctic Peninsula
Winter melt heats the firn to a depth of about 3 m, retarding or reversing winter cooling
Increased greenhouse gas concentrations could increase the occurrence of winter surface melt
Conservationists are increasingly engaging with the concept of human well‐being to improve the design and evaluation of their interventions. Since the convening of the influential Sarkozy Commission ...in 2009, development researchers have been refining conceptualizations and frameworks to understand and measure human well‐being and are starting to converge on a common understanding of how best to do this. In conservation, the term human well‐being is in widespread use, but there is a need for guidance on operationalizing it to measure the impacts of conservation interventions on people. We present a framework for understanding human well‐being, which could be particularly useful in conservation. The framework includes 3 conditions; meeting needs, pursuing goals, and experiencing a satisfactory quality of life. We outline some of the complexities involved in evaluating the well‐being effects of conservation interventions, with the understanding that well‐being varies between people and over time and with the priorities of the evaluator. Key challenges for research into the well‐being impacts of conservation interventions include the need to build up a collection of case studies so as to draw out generalizable lessons; harness the potential of modern technology to support well‐being research; and contextualize evaluations of conservation impacts on well‐being spatially and temporally within the wider landscape of social change. Pathways through the smog of confusion around the term well‐being exist, and existing frameworks such as the Well‐being in Developing Countries approach can help conservationists negotiate the challenges of operationalizing the concept. Conservationists have the opportunity to benefit from the recent flurry of research in the development field so as to carry out more nuanced and locally relevant evaluations of the effects of their interventions on human well‐being.
Ice shelves play a key role in the dynamics of marine ice sheets by buttressing grounded ice and limiting rates of ice flux to the oceans. In response to recent climatic and oceanic change, ice ...shelves fringing the West Antarctic Ice Sheet (WAIS) have begun to fragment and retreat, with major implications for ice-sheet stability. Here, we focus on the Thwaites Eastern Ice Shelf (TEIS), the remaining pinned floating extension of Thwaites Glacier. We show that TEIS has undergone a process of fragmentation in the last 5 years, including brittle failure along a major shear zone, formation of tensile cracks on the main body of the shelf, and a release of tabular bergs on both the eastern and western flanks. Simulations with the Helsinki Discrete Element Model (HiDEM) show that this pattern of failure is associated with high backstress from a submarine pinning point at the distal edge of the shelf. We show that a significant zone of shear, upstream of the main pinning point, developed in response to the rapid acceleration of the shelf between 2002 and 2006, seeding damage on the shelf. Subsequently, basal melting and positive feedback between damage and strain rates weakened TEIS, allowing damage to accumulate. Thus, although backstress on TEIS has likely diminished over time as the pinning point shrunk, accumulation of damage has ensured that the ice in the shear zone remained the weakest link in the system. Experiments with the BISICLES ice-sheet model indicate that additional damage to or unpinning of TEIS is unlikely to trigger significantly increased ice loss from WAIS, but the calving response to the loss of TEIS remains highly uncertain. It is widely recognised that ice-shelf fragmentation and collapse can be triggered by hydrofracturing and/or unpinning from ice-shelf margins or grounding points. Our results indicate a third mechanism, backstress triggered failure, that can occur if and when an ice shelf is no longer able to withstand stress imposed by pinning points. In most circumstances, pinning points are essential for ice-shelf stability, but as ice shelves thin and weaken, the concentration of backstress in damaged ice upstream of a pinning point may provide the seeds of their demise.
Complement is involved in developmental synaptic pruning and pathological synapse loss in Alzheimer's disease. It is posited that C1 binding initiates complement activation on synapses; C3 fragments ...then tag them for microglial phagocytosis. However, the precise mechanisms of complement-mediated synaptic loss remain unclear, and the role of the lytic membrane attack complex (MAC) is unexplored. We here address several knowledge gaps: (i) is complement activated through to MAC at the synapse? (ii) does MAC contribute to synaptic loss? (iii) can MAC inhibition prevent synaptic loss? Novel methods were developed and optimised to quantify C1q, C3 fragments and MAC in total and regional brain homogenates and synaptoneurosomes from WT and App.sup.NL-G-F Alzheimer's disease model mouse brains at 3, 6, 9 and 12 months of age. The impact on synapse loss of systemic treatment with a MAC blocking antibody and gene knockout of a MAC component was assessed in Alzheimer's disease model mice. A significant increase in C1q, C3 fragments and MAC was observed in App.sup.NL-G-F mice compared to controls, increasing with age and severity. Administration of anti-C7 antibody to App.sup.NL-G-F mice modulated synapse loss, reflected by the density of dendritic spines in the vicinity of plaques. Constitutive knockout of C6 significantly reduced synapse loss in 3xTg-AD mice. We demonstrate that complement dysregulation occurs in Alzheimer's disease mice involving the activation (C1q; C3b/iC3b) and terminal (MAC) pathways in brain areas associated with pathology. Inhibition or ablation of MAC formation reduced synapse loss in two Alzheimer's disease mouse models, demonstrating that MAC formation is a driver of synapse loss. We suggest that MAC directly damages synapses, analogous to neuromuscular junction destruction in myasthenia gravis. Keywords: Complement, Membrane attack complex, Synapse loss, Alzheimer's disease
Conventional surgery and radiotherapy for acromegaly have limitations. There are few data on the use of the somatostatin analog octreotide (Oct) as primary medical therapy. An open prospective study ...of 27 patients with newly diagnosed acromegaly was conducted in nine endocrine centers in the United Kingdom. Twenty patients had macroadenomas, and 7 had microadenomas. For the first 24 wk (phase 1), patients received sc Oct in an initial dose of 100 μg, 3 times daily, increased to 200 μg three times daily after 4 wk in the 13 patients whose mean serum GH remained greater than 5 mU/liter (2 μg/liter). Five-point GH profiles were performed at 0, 4, 12, and 24 wk, and high resolution pituitary imaging using a standard protocol was performed at 0, 12, and 24 wk (magnetic resonance imaging in 25 patients and computed tomography in 2). Tumor dimensions and volumes were calculated by a central, reporting neuroradiologist, and the results were audited by a second, independent neuroradiologist. After 24 wk, 15 patients proceeded to phase 2 of the study with a direct switch to monthly injections of the depot formulation of Oct, Sandostatin long-acting release (Oct-LAR). Further GH profiles were performed at 36 and 48 wk, and pituitary imaging was performed at 48 wk.
The median pretreatment serum GH concentration was 30.7 mU/liter (range, 6.7–141.4). During sc Oct, serum GH fell to less than 5 mU/liter in 9 patients (38%), and IGF-I fell to normal in 8 patients (33%). All 27 tumors shrank during sc Oct; for microadenomas the median tumor volume reduction was 49% (range, 12–73), and for macroadenomas it was 43% (range, 6–92). After 24 wk of Oct-LAR (end of phase 2), the GH level was less than 5 mU/liter in 11 of 14 patients (79%), and IGF-I was normal in 8 of 15 patients (53%). In the 15 patients given Oct-LAR (10 macroadenomas), wk 48 scans showed a further overall median tumor volume reduction of 24%. At the end of the study 79% of patients had mean serum GH levels below 5 mU/liter, 53% had normal IGF-I levels, and 73% showed greater than 30% tumor shrinkage. Twenty-nine percent of patients achieved all 3 targets, but no patient with pretreatment GH levels above 50 mU/liter did so at any stage of the study.
Primary medical therapy with Oct offers the prospect of normalization of GH/IGF-I levels together with substantial tumor shrinkage in a significant subset of acromegalic patients. This is most likely to occur in patients with pretreatment GH levels less than 50 mU/liter (20 μg/liter).
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