New topics in bradykinin research Maurer, M.; Bader, M.; Bas, M. ...
Allergy (Copenhagen),
November 2011, Volume:
66, Issue:
11
Journal Article
Peer reviewed
Open access
To cite this article: Maurer M, Bader M, Bas M, Bossi F, Cicardi M, Cugno M, Howarth P, Kaplan A, Kojda G, Leeb‐Lundberg F, Lötvall J, Magerl M. New topics in bradykinin research. Allergy 2011; 66: ...1397–1406.
Bradykinin has been implicated to contribute to allergic inflammation and the pathogenesis of allergic conditions. It binds to endothelial B1 and B2 receptors and exerts potent pharmacological and physiological effects, notably, decreased blood pressure, increased vascular permeability and the promotion of classical symptoms of inflammation such as vasodilation, hyperthermia, oedema and pain. Towards potential clinical benefit, bradykinin has also been shown to exert potent antithrombogenic, antiproliferative and antifibrogenic effects. The development of pharmacologically active substances, such as bradykinin receptor blockers, opens up new therapeutic options that require further research into bradykinin. This review presents current understanding surrounding the role of bradykinin in nonallergic angioedema and other conditions seen by allergists and emergency physicians, and its potential role as a therapeutic target.
The existence of a new force beyond the Standard Model is compelling because it could explain several striking astrophysical observations which fail standard interpretations. We searched for the ...light vector mediator of this dark force, the U boson, with the KLOE detector at the DAΦNE e+e− collider. Using an integrated luminosity of 1.54 fb−1, we studied the process e+e−→Uγ, with U→e+e−, using radiative return to search for a resonant peak in the dielectron invariant-mass distribution. We did not find evidence for a signal, and set a 90% CL upper limit on the mixing strength between the Standard Model photon and the dark photon, ε2, at 10−6–10−4 in the 5–520 MeV/c2 mass range.
To cite this article: Bossi F, Frossi B, Radillo O, Cugno M, Tedeschi A, Riboldi P, Asero R, Tedesco F, Pucillo C. Mast cells are critically involved in serum‐mediated vascular leakage in chronic ...urticaria beyond high‐affinity IgE receptor stimulation. Allergy 2011; 66: 1538–1545.
Background: Chronic urticaria (CU) is one of the most common skin disorders whose pathogenic mechanisms are not fully clarified. Autoimmune aetiology can be ascribed to 45% of patients with CU, and basophil histamine release is positive in 40% of cases. Our aim was to use a novel approach to evaluate the serum permeabilizing effect to identify the mediators of endothelial cell (EC) leakage and to define the role of mast cells (MCs) in the process.
Methods: Permeabilizing activity of sera from 19 patients with CU and 11 healthy blood donors was evaluated by measuring serum‐induced degranulation of two MC lines, expressing (LAD2) or lacking (HMC‐1) the IgE receptor. Mast cell supernatant (SN) was then incubated with an EC monolayer, and endothelial permeability was evaluated by Fluorescein isothiocyanate–bovine serum albumin leakage in a transwell system.
Results: All 19 patient sera failed to induce direct EC leakage, but 15/19 and 17/19 promoted degranulation of HMC‐1 and LAD2, respectively. Interestingly, 85% of autologous serum skin test‐negative sera were able to cause MC degranulation. Also, 17/19 SNs from HMC‐1 and all SNs from LAD2 incubated with CU sera increased endothelial permeability. Endothelial cell leakage remained unchanged after Ig depletion and was prevented by antihistamine, platelet‐activating factor or leukotriene antagonist.
Conclusions: Our study shows that CU sera are able to degranulate MCs through an IgE‐ and IgG‐independent mechanism. The nature of histamine‐releasing factors involved is still unclear, but our finding opens new ways to the understanding of the pathogenesis of CU, particularly in patients not showing circulating autoantibodies to FcεRI or IgE.
We have searched for a light vector boson U, the possible carrier of a “dark force”, with the KLOE detector at the DAΦNE e+e− collider, motivated by astrophysical evidence for the presence of dark ...matter in the Universe. Using e+e− collisions collected with an integrated luminosity of 239.3 pb−1, we look for a dimuon mass peak in the reaction e+e−→μ+μ−γ, corresponding to the decay U→μ+μ−. We find no evidence for a U vector boson signal. We set a 90% CL upper limit for the mixing parameter squared between the photon and the U boson of 1.6×10−5 to 8.6×10−7 for the mass region 520<mU<980 MeV.
We searched for the μ+μ− decay of a light vector gauge boson, also known as dark photon, in the e+e−→μ+μ−γISR process by means of the Initial State Radiation (ISR) method. We used 1.93 fb−1 of data ...collected by the KLOE experiment at the DAΦNE ϕ-factory. No structures have been observed over the irreducible μ+μ− background. A 90% CL limit on the ratio ε2=α′/α between the dark coupling constant and the fine structure constant of 3×10−6–2×10−7 has been set in the dark photon mass region between 519 MeV and 973 MeV. This new limit has been combined with the published result obtained investigating the hypothesis of the dark photon decaying into hadrons in e+e−→π+π−γISR events. The combined 90% CL limit increases the sensitivity especially in the ρ–ω interference region and excludes ε2 greater than (13−2)×10−7. For dark photon masses greater than 600 MeV the combined limit is lower than 8 ×10−7 resulting more stringent than present constraints from other experiments.
Tests of the T, CP and CPT symmetries in the neutral kaon system are performed by the direct comparison of the probabilities of a kaon transition process to its symmetry-conjugate. The exchange of in ...and out states required for a genuine test involving an antiunitary transformation implied by time-reversal is implemented exploiting the entanglement of K0K‾0 pairs produced at a ϕ-factory.
A data sample collected by the KLOE experiment at DAΦNE corresponding to an integrated luminosity of about 1.7 fb−1 is analysed to study the Δt distributions of the ϕ→KSKL→π+π−π±e∓ν and ϕ→KSKL→π±e∓ν3π0 processes, with Δt the difference of the kaon decay times. A comparison of the measured Δt distributions in the asymptotic region Δt≫τS allows to test for the first time T and CPT symmetries in kaon transitions with a precision of few percent, and to observe CP violation with this novel method.
We have measured the running of the effective QED coupling constant α(s) in the time-like region 0.6<s<0.975 GeV with the KLOE detector at DAΦNE using the Initial-State Radiation process e+e−→μ+μ−γ. ...It represents the first measurement of the running of α(s) in this energy region. Our results show a more than 5σ significance of the hadronic contribution to the running of α(s), which is the strongest direct evidence both in time- and space-like regions achieved in a single measurement. By using the e+e−→π+π− cross section measured by KLOE, the real and imaginary parts of the shift Δα(s) have been extracted. From a fit of the real part of Δα(s) and assuming the lepton universality the branching ratio BR(ω→μ+μ−)=(6.6±1.4stat±1.7syst)⋅10−5 has been determined.
Based on a sample of 300 million KS mesons produced in ϕ→KLKS decays recorded by the KLOE experiment at the DAΦNE e+e− collider we have measured the branching fraction for the decay KS→πμν. The KS ...mesons are identified by the interaction of KL mesons in the detector. The KS→πμν decays are selected by a boosted decision tree built with kinematic variables and by a time-of-flight measurement. Signal efficiencies are evaluated with data control samples of KL→πμν decays. A fit to the reconstructed muon mass distribution finds 7223±180 signal events. Normalising to the KS→π+π− decay events the result for the branching fraction is B(KS→πμν)=(4.56±0.11stat±0.17syst)×10−4. It is the first measurement of this decay mode and the result allows an independent determination of |Vus| and a test of the lepton-flavour universality.
Background and aims
The effect of surgical treatment for spontaneous intracerebral hemorrhage (ICH) remains uncertain. We conducted an observational retrospective cohort study on supra-centimeter ...spontaneous ICH treated with either neurosurgical or conservative management. The baseline demographics and risk factors were correlated with in-hospital mortality and 3 and 6-month survival rates stratified by management.
Methods
We included all patients with evidence of spontaneous ICH > 1 cm detected by CT and admitted between august 2020 and march 2021 to the “SMM” Hospital in Perugia.
Results
Onehundredandtwentytwo patients were included in the study, and 45% (n.55) were surgically treated. The mean age was 71.9 ± 15.3, and 61% (n.75) were males. Intra-hospital mortality ended up being 31% (n.38), 3 months-survival was 63% (n.77) and 6 months-survival was 60% (n.73).
From the multivariate analysis of the surgical patients versus medical patient, we observed that the surgical patients were younger (67.5 ± 14.9 vs 75.5 ± 14.7 y; OR 0.87; Cl 95% 0.85–0.94; p 0.001), with greater ICH volume at the onset (61 ± 39.4 cc vs 51 ± 64 cc; OR 1.03; Cl 95% 1.005–1.07; p 0.05), more midline shift (7.61 ± 5.54 mm vs 4.09 ± 5.88 mm; OR 1.37; Cl 95% 1.045–1.79; p 0.023), and a higher ICH score (3 vs 2 mean ICH score; OR 21.12; Cl 95% 2.6–170.6; p 0.004). Intra-hospital mortality in the surgical group and in the conservative treatment group was respectively 33% vs 30%, 3 month-survival was 64% vs 63% and 6 month- survival were 60% in both groups.
Conclusions
Our patient cohort shows no overall benefit from surgery over conservative treatment, but surgical patients were younger and had larger ICH volume.
The PADME beam line Monte Carlo simulation Bossi, F.; Branchini, P.; Buonomo, B. ...
The journal of high energy physics,
09/2022, Volume:
2022, Issue:
9
Journal Article
Peer reviewed
Open access
A
bstract
The PADME experiment at the DAΦNE Beam-Test Facility (BTF) of the INFN Laboratory of Frascati is designed to search for invisible decays of dark sector particles produced in ...electron-positron annihilation events with a positron beam and a thin fixed target, by measuring the missing mass of single-photon final states. The presence of backgrounds originating from beam halo particles can significantly reduce the sensitivity of the experiment. To thoroughly understand the origin of the beam background contribution, a detailed G
eant
4-based Monte Carlo simulation has been developed, containing a full description of the detector together with the beam line and its optical elements. This simulation allows the full interactions of each particle to be described, both during beam line transport and during detection, a possibility which represents an innovative way to obtain reliable background predictions.
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