•The rs11030099 of brain-derived neurotrophic factor neurotrophin is associated with nerve damage in leprosy patients.•The rs11030099 is not associated with brain-derived neurotrophic factor serum ...level.•The rs11030099 is located in a miR-26a binding region.•The miR-26 and rs11030099 may be acting synergistically.•Other investigated single nucleotide polymorphisms of neurotrophins are not associated with leprosy phenotypes.
Mycobacterium leprae is able to infect Schwann cells leading to neural damage. Neurotrophins are involved in nervous system plasticity and impact neural integrity during diseases. Investigate the association between single nucleotide polymorphisms in neurotrophin genes and leprosy phenotypes, especially neural damage.
We selected single nucleotide polymorphisms in neurotrophins or their receptors genes associated with neural disorders: rs6265 and rs11030099 of brain-derived neurotrophic factor (BDNF), rs6330 of BDNF, rs6332 in NT3 and rs2072446 of P75NTR. The association of genetic frequencies with leprosy phenotypes was investigated in a case-control study.
An association of the BDNF single nucleotide polymorphism rs11030099 with the number of affected nerves was demonstrated. The “AA+AC” genotypes were demonstrated to be protective against nerve impairment. However, this variation does not affect BDNF serum levels. BDNF is an important factor for myelination of Schwann cells and polymorphisms in this gene can be associated with leprosy outcome. Moreover, rs11030099 is located in the binding region for micro-RNA (miRNA) 26a that could be involved in control of BDNF expression. We demonstrated different expression levels of this miRNA in polar forms of leprosy.
Our findings demonstrate for the first time an association between the polymorphism rs11030099 in the BDNF gene and neural commitment in leprosy and may indicate a possible role of miRNA-26a acting synergistically to these genetic variants in neural damage development.
Background
This study evaluated and compared cardiorespiratory and blood gas parameters, as well as sedation, analgesia and recovery of two protocols: ketamine (10 mg/kg) or dexmedetomidine ...(10 μg/kg), with midazolam (0.5 mg/kg) and butorphanol (0.3 mg/kg), IM (KBM and DBM, respectively) in brown howler monkeys (Alouatta guariba clamitans).
Material and methods
Twelve brown howler monkeys were selected in two groups and evaluated for cardiorespiratory parameters and sedation, from 5‐30 minutes after latency. Blood gas and arterial lactate were taken at 5 and 30 minutes. In the end, time and quality of recovery were evaluated.
Results
The HR in DBM group was significantly lower at all times. The sedation score was higher in DBM. Recovery in DBM was faster. All animals had moderate hypoxaemia.
Conclusion
Both protocols produce satisfactory anaesthesia and analgesia, but DBM provides deeper sedation with faster recovery. Oxygen supplementation is recommended in both due to hypoxaemia.
to determine the prevalence and key factors associated with fatigue in chronic low back pain patients.
cross-sectional study of 215 chronic low back pain patients from three health care centers and ...two industrial corporations. The crude prevalence of fatigue and its 95% confidence interval (CI) were calculated. Associations between fatigue and the independent variables were measured.
the prevalence of fatigue among the participants was 26.0% 95% CI: 20.3-32.5. Fatigue was independently associated with depression and self-efficacy. An increase of one unit in the score of depression increased the risk of fatigue by 9%; an increase of one unit in the score of self-efficacy reduced the risk of fatigue by 2%.
fatigue was prevalent in chronic low back pain patients and associated with depression and self-efficacy. Knowing these factors can direct strategies for prevention and control of fatigue in chronic low back pain patients.
Abstract
Background
A survey was conducted in three hospitals, between July 2016 and June 2018, about surgical site infection (SSI) in patients undergoing surgeries to correct aortic artery aneurysms ...in the city of Belo Horizonte, with more than 3,000,000 of inhabitants. The general objective is to statistically evaluate such incidences and enable an analysis of the predictive power of SSI, through MLP (Multilayer Perceptron) pattern recognition algorithms.
Methods
Through the Hospital Infection Control Committees (CCIH) of the hospitals involved in the research, data collection on SSI was carried out. Such data is used in the analysis during your routine SSI surveillance procedures. Thus, three procedures were performed: a treatment of the database collected for use of intact samples; a statistical analysis on the profile of the collected hospitals and; an assessment of the predictive power of five types of MLPs (Backpropagation Standard, Momentum, Resilient Propagation, Weight Decay and Quick Propagation) for SSI prediction. The MLPs were tested with 3, 5, 7 and 10 neurons in the hidden layer and with a division of the database for the resampling process (65% or 75% for testing, 35% or 25% for validation). They were compared by measuring the AUC (Area Under the Curve - ranging from 0 to 1) for each of the configurations.
Results
From 600 records, 575 were complete for analysis. It was found that: the average age is 68 years (from 24 to 98 years); the average hospital stay is 9 days (with a maximum of 127 days), the death rate reached 6.43% and the SSI rate 2.78%. A maximum prediction power of 0.75 was found.
Conclusion
There was a loss of 4% of the database samples due to the presence of noise. It was possible to evaluate the profile of the three hospitals. The predictive process presented configurations with results that reached 0.75, which promises the use of the structure for the monitoring of automated SSI for patients undergoing surgery to correct aortic artery aneurysms. To optimize data collection, enable other hospitals to use the prediction tool and minimize noise from the database, two mobile application were developed: one for monitoring the patient in the hospital and another for monitoring after hospital discharge. The SSI prediction analysis tool is available at www.nois.org.br.
Disclosures
All Authors: No reported disclosures
OBJECTIVES: to determine the prevalence and key factors associated with fatigue in chronic low back pain patients. METHODS: cross-sectional study of 215 chronic low back pain patients from three ...health care centers and two industrial corporations. The crude prevalence of fatigue and its 95% confidence interval (CI) were calculated. Associations between fatigue and the independent variables were measured. RESULTS: the prevalence of fatigue among the participants was 26.0% 95% CI: 20.3 - 32.5. Fatigue was independently associated with depression and self-efficacy. An increase of one unit in the score of depression increased the risk of fatigue by 9%; an increase of one unit in the score of self-efficacy reduced the risk of fatigue by 2%. CONCLUSIONS: fatigue was prevalent in chronic low back pain patients and associated with depression and self-efficacy. Knowing these factors can direct strategies for prevention and control of fatigue in chronic low back pain patients.OBJETIVOS: Determinar la prevalencia y factores asociados con la fatiga en pacientes con dolor lumbar crónico. MÉTODOS: Estudio transversal con 215 pacientes con dolor lumbar crónico en tres servicios de salud y dos industrias. La prevalencia de la fatiga y su intervalo de confianza (IC) se calcularon. Las asociaciones entre variables independientes y la fatiga se calcularon. RESULTADOS: La prevalencia de la fatiga en los pacientes con dolor lumbar crónico fue del 26% 20,3 a 32,5, IC 95%. La fatiga se asocia con la depresión y la autoeficacia. El aumento de un punto en la puntuación de depresión aumentó un 9% el riesgo de fatiga y un aumento de un punto en la auto-eficacia reduce el riesgo de la fatiga en el 2%. CONCLUSIONES: La fatiga es frecuente en pacientes con dolor lumbar crónico y se asocia con la depresión y la autoeficacia. Conocer estos factores puede dirigir las estrategias de prevención y control de la fatiga en pacientes con dolor lumbar crónico.OBJETIVOS: determinar a prevalência e os principais fatores relacionados à fadiga em pacientes com dor lombar crônica. MÉTODOS: trata-se de estudo transversal, com a participação de 215 pacientes com dor lombar crônica, em três centros de saúde e duas indústrias. Foram calculadas a prevalência bruta de fadiga e seu intervalo de confiabilidade de 95% (IC). RESULTADOS: a prevalência de fadiga entre os participantes com dor lombar crônica foi de 26% 20,3-32,5; IC 95%. A fadiga foi associada à depressão e à autoeficácia de forma independente. O aumento de um ponto no escore de depressão aumentou o risco de fadiga em 9% e o aumento de um ponto no escore de autoeficácia reduziu o risco de fadiga em 2%. CONCLUSÕES: fadiga foi um fator predominante em pacientes com dor lombar crônica e indicou relação com depressão e autoeficácia. O conhecimento desses fatores pode orientar estratégias para prevenção e controle da fadiga em pacientes com dor lombar crônica.
A incapacidade relacionada à dor lombar crônica (DLC) é um fenômeno complexo e multifatorial. O objetivo desse estudo foi identificar a prevalência e os fatores associados à incapacidade em pacientes ...com dor lombar crônica. Estudo transversal com amostra composta por 177 pacientes com DLC, de três serviços de saúde; que responderam ao formulário com dados demográficos, ao Inventário de Depressão de Beck, às Escalas Oswestry Disability Index, de autoeficácia para dor crônica, Tampa de Cinesiofobia e de Fadiga de Piper. A prevalência de incapacidade foi de 65% (IC95%: 57,5 - 72,0) e era de moderada a grave em 80,7% dos pacientes. O modelo de regressão múltipla identificou três fatores independentemente associados à incapacidade: ausência de trabalho remunerado, autoeficácia baixa e depressão. Os fatores associados à incapacidade identificados são modificáveis. Intervenções como recolocação no trabalho, tratamento para a depressão e reconceitualização da crença de autoeficácia podem ter um impacto importante na prevenção e redução de incapacidade.
La discapacidad relacionada con el dolor lumbar crónico (DLC) es complejo y multifactorial. El objetivo fue identificar la prevalencia y factores asociados a la discapacidad en pacientes con DLC. Estudio transversal con 177 pacientes de tres servicios de salud; que respondieron al formulario con los datos demográficos, Inventario de Depresión de Beck, Escala de discapacidad de Oswestry, autoeficacia para el dolor crónico, Tampa kinesiophobia and Piper fatiga. La prevalencia de la discapacidad fue del 65% (IC 95%: 57,5 a 72,0) y de moderada a severa en 80,7% de los pacientes. El modelo de regresión se identificó tres factores independientemente asociados con la discapacidad: la falta de trabajo, baja autoeficacia y la depresión. Los factores identificados son modificables. Intervenciones como el trabajo de sustitución, el tratamiento de la depresión y la reconceptualización de la creencia de la autoeficacia puede tener un impacto importante en la prevención y reducción de la discapacidad.
Disability related to chronic low back pain (CLBP) is a complex and multidimensional phenomenon. The aim of the study was to identify the prevalence of disability and factors associated with disability outcome in 177 CLBP adults. Respondents were recruited from three health care service centers and answered questions from: Demographic Identification Form, Oswestry Disability Index, Chronic Pain Self-efficacy Scale, Tampa Scale Kinesiophobia, Beck Depression Inventory, and the Revised Piper Fatigue Scale. The prevalence of disability among the respondents was 65% (95% CI: 57.5 - 72.0), and disability was moderate to severe in 80.7% of them. The multiple regression model identified three factors as independently associated with disability: work situation, low self-efficacy and depression. The factors identified to be associated with disability are modifiable. Interventions such as work relocation, depression treatment and re-conceptualization of self-efficacy may have an important impact in preventing and reducing disability in chronic low back pain patients.
Disability related to chronic low back pain (CLBP) is a complex and multidimensional phenomenon. The aim of the study was to identify the prevalence of disability and factors associated with ...disability outcome in 177 CLBP adults. Respondents were recruited from three health care service centers and answered questions from: Demographic Identification Form, Oswestry Disability Index, Chronic Pain Self-efficacy Scale, Tampa Scale Kinesiophobia, Beck Depression Inventory, and the Revised Piper Fatigue Scale. The prevalence of disability among the respondents was 65% (95% CI: 57.5 - 72.0), and disability was moderate to severe in 80.7% of them. The multiple regression model identified three factors as independently associated with disability: work situation, low self-efficacy and depression. The factors identified to be associated with disability are modifiable. Interventions such as work relocation, depression treatment and re-conceptualization of self-efficacy may have an important impact in preventing and reducing disability in chronic low back pain patients.
A incapacidade relacionada à dor lombar crônica (DLC) é um fenômeno complexo e multifatorial. O objetivo desse estudo foi identificar a prevalência e os fatores associados à incapacidade em pacientes ...com dor lombar crônica. Estudo transversal com amostra composta por 177 pacientes com DLC, de três serviços de saúde; que responderam ao formulário com dados demográficos, ao Inventário de Depressão de Beck, às Escalas Oswestry Disability Index, de autoeficácia para dor crônica, Tampa de Cinesiofobia e de Fadiga de Piper. A prevalência de incapacidade foi de 65% (IC95%: 57,5 - 72,0) e era de moderada a grave em 80,7% dos pacientes. O modelo de regressão múltipla identificou três fatores independentemente associados à incapacidade: ausência de trabalho remunerado, autoeficácia baixa e depressão. Os fatores associados à incapacidade identificados são modificáveis. Intervenções como recolocação no trabalho, tratamento para a depressão e reconceitualização da crença de autoeficácia podem ter um impacto importante na prevenção e redução de incapacidade.
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