Scale is a fundamental concept that has attracted persistent attention in geography literature over the past several decades. However, it creates enormous confusion and frustration, particularly in ...the context of geographic information science, because of scale-related issues such as image resolution and the modifiable areal unit problem (MAUP). This paper argues that the confusion and frustration arise from traditional Euclidean geometric thinking, in which locations, directions, and sizes are considered absolute, and it is now time to revise this conventional thinking. Hence, we review fractal geometry, together with its underlying way of thinking, and compare it to Euclidean geometry. Under the paradigm of Euclidean geometry, everything is measurable, no matter how big or small. However, most geographic features, due to their fractal nature, are essentially unmeasurable or their sizes depend on scale. For example, the length of a coastline, the area of a lake, and the slope of a topographic surface are all scale-dependent. Seen from the perspective of fractal geometry, many scale issues, such as the MAUP, are inevitable. They appear unsolvable, but can be dealt with. To effectively deal with scale-related issues, we present topological and scaling analyses illustrated by street-related concepts such as natural streets, street blocks, and natural cities. We further contend that one of the two spatial properties, spatial heterogeneity, is de facto the fractal nature of geographic features, and it should be considered the first effect among the two, because it is global and universal across all scales, which should receive more attention from practitioners of geography.
Fish-eye lenses are convenient in such applications where a very wide angle of view is needed, but their use for measurement purposes has been limited by the lack of an accurate, generic, and ...easy-to-use calibration procedure. We hence propose a generic camera model, which is suitable for fish-eye lens cameras as well as for conventional and wide-angle lens cameras, and a calibration method for estimating the parameters of the model. The achieved level of calibration accuracy is comparable to the previously reported state-of-the-art
Advanced paternal age (APA) is associated with infertility and other reproductive risks. Studies looking at APA and outcomes have used different paternal age cut‐offs, which has complicated ...systematic evaluations of reproductive risk associated with paternal aging. This review of the literature suggests that the impact of paternal aging on adverse reproductive outcomes is small, but significant. Studies suggest the incidence of paternal age effect disorders attributed to de novo autosomal dominant mutations is less than 0.5%. Other risks associated with APA include infertility, miscarriage, birth defects, poor neurodevelopmental outcomes, and childhood cancer. Although the increasing prevalence of APA has mirrored the rise in maternal age, this topic has not received similar attention. In this review, we summarize the available literature on the reproductive risks associated with APA to provide a framework for comprehensive genetic counseling and evidence‐based management of APA pregnancies.
What is already known about this topic?
The increasing prevalence of APA has mirrored the rise in maternal age, but there has not been similar attention to the associated risks.
What does this study add?
In this review, we summarize the reproductive risks associated with APA and suggest guidelines for evidence‐based management of these pregnancies.
Further studies are needed to assess providers' understanding of APA risks and the use of cell free DNA and prenatal whole exome sequencing (WES) to identify de novo paternal age effect (PAE) mutations.
►AHP is sensitive to the level of uncertainty in fuzzification. ► The paper can serve as a guideline on doing a sensitivity analysis in spatial MCDA. ► The fuzzification may be used for exploring ...uncertainties in AHP.
Multicriteria decision analysis (MCDA) involves techniques which relatively recently have received great increase in interest for their capabilities of solving spatial decision problems. One of the most frequently used techniques of MCDA is Analytic Hierarchy Process (AHP). In the AHP, decision-makers make pairwise comparisons between different criteria to obtain values of their relative importance. The AHP initially only dealt with crisp numbers or exact values in the pairwise comparisons, but later it has been modified and adapted to also consider fuzzy values. It is necessary to empirically validate the ability of the fuzzified AHP for solving spatial problems. Further, the effects of different levels of fuzzification on the method have to be studied. In the context of a hypothetical GIS-based decision-making problem of locating a dam in Costa Rica using real-world data, this paper illustrates and compares the effects of increasing levels of uncertainty exemplified through different levels of fuzzification of the AHP. Practical comparison of the methods in this work, in accordance with the theoretical research, revealed that by increasing the level of uncertainty or fuzziness in the fuzzy AHP, differences between results of the conventional and fuzzy AHPs become more significant. These differences in the results of the methods may affect the final decisions in decision-making processes. This study concludes that the AHP is sensitive to the level of fuzzification and decision-makers should be aware of this sensitivity while using the fuzzy AHP. Furthermore, the methodology described may serve as a guideline on how to perform a sensitivity analysis in spatial MCDA. Depending on the character of criteria weights, i.e. the degree of fuzzification, and its impact on the results of a selected decision rule (e.g. AHP), the results from a fuzzy analysis may be used to produce sensitivity estimates for crisp AHP MCDA methods.
We report the INTernational Gamma-ray Astrophysics Laboratory (INTEGRAL) detection of the short gamma-ray burst GRB 170817A (discovered by Fermi-GBM) with a signal-to-noise ratio of 4.6, and, for the ...first time, its association with the gravitational waves (GWs) from binary neutron star (BNS) merging event GW170817 detected by the LIGO and Virgo observatories. The significance of association between the gamma-ray burst observed by INTEGRAL and GW170817 is 3.2 , while the association between the Fermi-GBM and INTEGRAL detections is 4.2 . GRB 170817A was detected by the SPI-ACS instrument about 2 s after the end of the GW event. We measure a fluence of (1.4 0.4 0.6) × 10−7 erg cm−2 (75-2000 keV), where, respectively, the statistical error is given at the 1 confidence level, and the systematic error corresponds to the uncertainty in the spectral model and instrument response. We also report on the pointed follow-up observations carried out by INTEGRAL, starting 19.5 hr after the event, and lasting for 5.4 days. We provide a stringent upper limit on any electromagnetic signal in a very broad energy range, from 3 keV to 8 MeV, constraining the soft gamma-ray afterglow flux to <7.1 × 10−11 erg cm−2 s−1 (80-300 keV). Exploiting the unique capabilities of INTEGRAL, we constrained the gamma-ray line emission from radioactive decays that are expected to be the principal source of the energy behind a kilonova event following a BNS coalescence. Finally, we put a stringent upper limit on any delayed bursting activity, for example, from a newly formed magnetar.
Abstract
Structural, geophysical and age data indicate that the tilted cross-section of the Variscan continental crust exposed in the Serre of southern Calabria forms the uppermost Alpine nappe ...(‘Serre nappe’) of three Variscan basement slices derived from the southern European margin. This Alpine nappe stack is a fragment of the western Mediterranean Alps and rests now, after Miocene emplacement, on top of the Apennine carbonate platform. We report for the first time a P–T path for prograde Alpine metamorphism, which is restricted to the two lower nappes (Castagna and Bagni nappes) that are squeezed between cooler tectonic units, the Serre nappe above and the Apennine platform below. Therefore, we attribute their metamorphism to tectonic loading and concomitant shear heating during Eocene south-directed overthrusting of the crustal-scale Serre nappe. In the underlying Castagna nappe, Alpine metamorphism is only locally recorded, mainly by new growth of garnet, forming at the expense of retrogressed Variscan biotite dated at 43 Ma. The local existence of Alpine besides relict Variscan mineral assemblages in the strongly but heterogeneously overprinted rocks allows for characterization of metamorphic evolutions during both the Alpine and Variscan orogeneses in the former intermediate level of the Variscan crust of Calabria. The metamorphic evolutions have been reconstructed through P–T pseudosection modelling for Al-rich metasediments. In the Castagna nappe, rarely preserved Variscan garnet–sillimanite–biotite–ilmenite–plagioclase–quartz (± K-feldspar ± Si-poor white mica) assemblages formed under amphibolite-facies subsolidus conditions (650 ± 60 °C, 4·0 ± 0·5 kbar). During subsequent decompression and cooling to greenschist-facies conditions garnet was replaced by biotite–sillimanite and later by white mica–chlorite intergrowths. Retrogression of Variscan biotite is evidenced by the exsolution of ilmenite along grain boundaries and cleavages, textures that were subsequently overgrown by Alpine garnet coexisting with Si-rich white mica, rare chloritoid (in metapelites), and hornblende (in metagreywackes). Alpine garnet shows prograde zoning and is Ca-rich, and thus is distinct from unzoned and Ca-poor Variscan garnet porphyroblasts. Estimated conditions (520 ± 40 °C, 8·0 ± 1·0 kbar) record elevated pressures during Alpine lower amphibolite-facies metamorphism. In the lowermost Bagni nappe, rare prograde-zoned, Ca-rich garnet in strongly retrogressed mylonitic quartz-phyllites allows isopleth thermobarometry, which indicates lower amphibolite-facies conditions (555 ± 10 °C, 7·4 ± 0·3 kbar) resembling those for Alpine garnet growth in the Castagna nappe. The similar clockwise P–T paths for prograde Alpine metamorphism and the consistent peak pressures of 7–9 kbar in the Castagna and Bagni nappes point to a joint short-lived metamorphism during overthrusting of the crustal-scale Serre nappe within the south European margin during the north-directed subduction of the Alpine Tethys. South-directed overthrusting of the now tilted Variscan crustal section of the Serre along the up to 500 m thick mylonite horizon of the Curinga–Girifalco Line is in agreement with seismic data indicating an extended, few kilometres thick low-velocity zone (Bagni and Castagna nappes and mylonites of the Curinga–Girifalco Line) below the exposed lower crustal section of the Serre nappe. Alpine tectonic transport direction, timing and metamorphic conditions described here are consistent with those reported from the Aspromonte area in southernmost Calabria, suggesting a coeval Alpine history characterized by metamorphism owing to nappe loading and concomitant shear heating. The Alpine subduction–erosion–accretion processes inferred here for the Calabrian basement nappes resemble those proposed for the Dent Blanche nappe system in the Western Alps.
The increasing rate of autoimmune disorders and cancer in recent years has been a controversial issue in all aspects of prevention, diagnosis, prognosis and treatment. Among dietary factors, ...flavonoids have specific immunomodulatory effects that might be of importance to several cancers. Over different types of immune cells, T lymphocytes play a critical role in protecting the immune system as well as in the pathogenesis of specific autoimmune diseases. One of the important mediators of metabolism and immune system is mTOR, especially in T lymphocytes. In the current review, we assessed the effects of flavonoids on the immune system and then their impact on the mTOR pathway. Flavonoids can suppress mTOR activity and are consequently able to induce the T regulatory subset.
New technology has provided new tools for effective spatial planning. Through the example of locating suitable sites for urban development in Ulaanbaatar, this paper illustrates how multicriteria ...decision analysis and geographical information systems can be used for more effective urban planning. Several constraint and factor criteria were identified, transformed into map layers, and weighted together using the analytic hierarchy process. Besides localization results, this study shows the effect of using poor elevation data and how a sensitivity analysis can be applied to yield further information, spot weighting weaknesses, and assess the quality of the criteria.
Facing the challenges of environmental and social changes, sustainable management of ecosystem services is a worldwide priority. The Programme on Ecosystem Change and Society (PECS) approach provides ...a unique opportunity for promoting transdisciplinary place-based comparative research for social-ecological systems (SES) management. As part of the PECS-sponsored WaterSES project, we used four place-based SES research sites to analyze patterns in perceptions of ecosystem services. Our data come from about 1,500 face-to-face surveys conducted in southern Spain, the south-central Great Plains of Oklahoma (USA), and the Portneuf and Treasure Valleys, Idaho (USA). Specifically, this study aimed to (1) describe and compare perceptions of ecosystem services within and across SES sites, (2) explore how perceptions of ecosystem services vary among local respondents and by sociodemographic factors, and (3) evaluate the overall relationship between place-based SES contexts and ecosystem service perceptions. Our results revealed that cultural ecosystem services were the most highly mentioned among those surveyed across all four sites. However, we found differences in how ecosystem services were perceived among the four SES contexts. For instance, both, social (e.g., gender, education) and local ecological (e.g., land use and climate) characteristics play roles in influencing people's perceptions of which services are important. Overall, our findings suggest the relationship between people's perceptions of ecosystem services and their social-environmental context is complex, which highlights the value of the PECS approach for crafting more effective and inclusive landscape management strategies.
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