This study describes the prevalence of SARS-CoV-2 co-infection with noncoronavirus respiratory pathogens in a sample of symptomatic patients undergoing PCR testing in March 2020.
Brown studies recent developments and research in the methods and applications of the bond valence model. The history of the model and its theorems are also discussed.
This article presents the simultaneous magnetic and structural topology optimization of a transverse laminated synchronous reluctance machine rotor using a solid isotropic with material penalization ...(SIMP)-based approach with the globally convergent method of moving asymptotes (GCMMA) optimization algorithm. Magneto-structural single and multi-objective optimization formulations are presented. The single objective formulation maximizes the average torque subject to constraints on torque ripple, Von Mises stress, and compliance. The multiobjective formulation simultaneously maximizes average torque and minimizes compliance subject to constraints on torque ripple and Von Mises stress. In both optimization formulations, the electrical steel densities in the rotor mesh elements are the control variables. Including stress and compliance in the optimization formulation ensures a structurally feasible design. The design-dependent centripetal force contributed by each element in the rotor mesh is considered dependent on its density and mass. An intermediate density material issue is observed where the density of the material in a mesh element does not converge fully to air or electrical steel. This issue is addressed through the use of a thresholding mass function which forces the convergence of the mass but not the density. The two optimization formulations are compared for rotors operating at 4000 and 12 000 r/min. An initial magnetic only topology optimization is used to seed the magneto-structural topology optimization to decrease the computational time. The impact of the magnetic only seed and rotor mesh density on the optimization outcomes is also examined.
A magneto-structural combined dimensional and topology optimization approach for interior permanent magnet synchronous machine (IPMSM) rotor design is proposed using the solid isotropic material with ...penalization (SIMP) density-based topology optimization method. This method optimizes the location and dimensions of the permanent magnets (PMs) embedded in the rotor, while simultaneously optimizing the lamination flux barriers using topology optimization. To allow for the location and dimensions of the PMs to change a Laplace smoothing mesh deformation technique is used. Three examples of IPMSM rotor optimizations are presented to demonstrate the proposed approach. In addition, a geometric template-based optimization is carried out for a comparison to one of the dimensional and topology optimized examples to better illustrate the difference.
: Manipulation of the cellular stress response offers strategies to protect brain cells from damage induced by ischemia and neurodegenerative diseases. Overexpression of Hsp70 reduced ischemic ...injury in the mammalian brain. Investigation of the domains within Hsp70 that confers ischemic neuroprotection revealed the importance of the carboxyl‐terminal domain. Arimoclomol, a coinducer of heat shock proteins, delayed progression of amyotrophic lateral sclerosis (ALS) in a mouse model in which motor neurons in the spinal cord and motor cortex degenerate. Celastrol, a promising candidate as an agent to counter neurodegenerative diseases, induced expression of a set of Hsps in differentiated neurons grown in tissue culture. Heat shock “preconditioning” protected the nervous system at the functional level of the synapse and selective overexpression of Hsp70 enhanced the level of synaptic protection. Following hyperthermia, constitutively expressed Hsc70 increased in synapse‐rich areas of the brain where it associates with Hsp40 to form a complex that can refold denatured proteins. Stress tolerance in neurons is not solely dependent on their own Hsps but can be supplemented by Hsps from adjacent glial cells. Hence, application of exogenous Hsps at neural injury sites is an effective strategy to maintain neuronal viability.
This paper presents a magneto-structural combined dimensional and topology optimization technique for interior permanent magnet synchronous machine (IPMSM) and wound field synchronous machine (WFSM) ...rotors. Dimensional changes to the permanent magnet (PM) and rotor winding location or size are accomplished by interpolating or projecting a smoothed Heaviside rectangular function representing the presence of PM material onto the IPMSM rotor design domain mesh, whereas the presence of copper material for WFSM rotor is interpolated in the same manner. A density based Solid Isotropic Material with Penalization (SIMP) topology optimization approach is then used to vary the presence of electrical steel in mesh elements to form flux barriers around the PM. The proposed method enforces a defined shape for the PM without requiring the mesh in the design domain to be deformed. Four examples are presented to demonstrate the technique: two flat bar IPMSM, one V-shaped IPMSM and a WFSM. A comparative study is performed on one of the flat bar IPMSMs using Metamodel of Optimal Prognosis (MOP) based method.
As a metric for measuring the combined space harmonic content of electric machine winding magnetomotive force (MMF), the winding total harmonic distortion (THD) is defined with an infinite series. ...Without truncation, the exact THD can be evaluated via a "family grouping" facilitated by a "family sum" over the fewest possible winding factors. Uniformly applicable to distributed windings and fractional-slot concentrated windings (FSCWs), this procedure also explains the inherent difference in harmonic content between both winding categories. Furthermore, the minimal THD (mTHD) that can be achieved by optimizing a winding is revealed with a closed-form expression. While intended for windings, the mTHD concept also benefits the design of low harmonic content rotor magnetic fields. Examples of both winding and rotor mTHD designs are provided.
Approximately 30 % of colorectal carcinomas develop via the serrated neoplasia pathway characterized by widespread DNA methylation and frequent
BRAF
mutation. Serrated polyps represent a ...heterogeneous group of polyps which are the precursor lesions to serrated pathway colorectal carcinomas. The histological classification of serrated polyps has evolved over the last two decades to distinguish three separate entities: hyperplastic polyp, sessile serrated adenoma (SSA), and traditional serrated adenoma (TSA). The malignant potential of SSAs and TSAs has been clearly demonstrated. SSAs are more challenging to detect by colonoscopy and are likely to account for some interval carcinomas of the proximal colon. Serrated polyposis syndrome is now widely recognized as conferring a high risk of colorectal carcinoma although its cause remains elusive. The current understanding of the actual malignant potential of each serrated polyp subtype is still limited due to the lack of large-scale prospective studies. Patient management guidelines have been recently updated although high-level evidence to support them is still required.
This paper studies the design of electric machine windings with reduced magnetomotive force (MMF) space harmonic content by adjusting the slot distribution and coil turns. Closed-form expressions for ...the winding factor and harmonic magnitudes established from a mathematical representation of winding functions are used to formulate the MMF space harmonic suppression problem. The framework is applicable to both distributed windings and fractional-slot concentrated windings (FSCWs) and can be solved with different techniques. No special requirements on the slot/pole combination and the number of layers are necessary. One example uses a linear algebraic technique to solve simultaneous equations and the result is a mixed-layer distributed winding. The process also reveals the criterion when multiple requirements on the winding factor and harmonic magnitudes can be satisfied concurrently. Contour plots are included to provide additional graphical insight. Another example designs a 24-slot 22-pole FSCW subset with numerical optimization. The resultant winding is a four-layer FSCW with two subsets and 3/4 of the harmonic orders are eliminated. The performance improvement of this winding is verified with finite-element simulations.
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