Abstract The term “exposome” describes the totality of exposures to which an individual is subjected from conception to death. It includes both external and internal factors as well as the human ...body’s response to these factors. Current exposome research aims to understand the effects all factors have on specific organs, yet today, the exposome of human skin has not received major attention and a corresponding definition is lacking. This review was compiled with the collaboration of European scientists, specialized in either environmental medicine or skin biology. A comprehensive review of the existing literature was performed using PubMed. The search was restricted to exposome factors and skin aging. Key review papers and all relevant, epidemiological, in vitro , ex vivo and clinical studies were analyzed to determine the key elements of the exposome influencing skin aging. Here we propose a definition of the skin aging exposome. It is based on a summary of the existing scientific evidence for the role of exposome factors in skin aging. We also identify future research needs which concern knowledge about the interaction of distinct exposomal factors with each other and the resulting net effects on skin aging and suggest some protective measures.
Nucleotide binding site leucine-rich repeat (NLR) proteins of the plant innate immune system are negatively regulated by the miR482/2118 family miRNAs that are in a distinct 22-nt class of miRNAs ...with a double mode of action. First, they cleave the target RNA, as with the canonical 21-nt miRNAs, and second, they trigger secondary siRNA production using the target RNA as a template. Here, we address the extent to which the miR482/2118 family affects expression of NLR mRNAs and disease resistance. We show that structural differences of miR482/2118 family members in tomato (Solanum lycopersicum) are functionally significant. The predicted target of the miR482 subfamily is a conserved motif in multiple NLR mRNAs, whereas for miR2118b, it is a noncoding RNA target formed by rearrangement of several different NLR genes. From RNA sequencing and degradome data in lines expressing short tandem target mimic (STTM) RNAs of miR482/2118, we confirm the different targets of these miRNAs. The effect on NLR mRNA accumulation is slight, but nevertheless, the tomato STTM lines display enhanced resistance to infection with the oomycete and bacterial pathogens. These data implicate an RNA cascade of miRNAs and secondary siRNAs in the regulation of NLR RNAs and show that the encoded NLR proteins have a role in quantitative disease resistance in addition to dominant gene resistance that has been well characterized elsewhere. We also illustrate the use of STTM RNA in a biotechnological approach for enhancing quantitative disease resistance in highly bred cultivars.
Plastic pollution is a rapidly worsening environmental problem, especially in oceanic habitats. Environmental pollution with microplastic particles is also causing food consumed by humans to be ...increasingly polluted, including table salts. Therefore, we present the first study which focuses only on table salt products purchased in Taiwan which we examined for the presence of microplastics. We used Fourier transform infrared spectroscopy to identify the polymer type of each particle. Within 4.4 kg of salt, we detected 43 microplastic particles which averages to 9.77 microplastic particles/kg. The identified polymer types were, in descending abundance, polypropylene, polyethylene, polystyrene, polyester, polyetherimide, polyethylene terephthalate, and polyoxymethylene. We combined our novel results with those of previous studies to provide the first global review of microplastic contamination of table salts. We found that 94% of salt products tested worldwide contained microplastics, with 3 out of 27 polymer types (polyethylene terephthalate, polypropylene, polyethylene) accounting for the majority of all particles. Averaging over seven separate studies, table salts contain a mean of 140.2 microplastic particles/kg. With a mean annual salt consumption of ~3.75 kg/year, humans therefore annually ingest several hundred microplastic particles from salt alone.
The Energetic Proton, Electron, and Alpha Detector (EPEAD) and High Energy Proton and Alpha Detector (HEPAD) instruments on the Geostationary Operational Environmental Satellite (GOES) spacecraft ...have served over many years as monitors of the solar particle intensities, surveying the Sun and measuring in situ its effect on the near‐Earth solar‐terrestrial environment. However, the reconstruction of the differential energy spectra is affected by large uncertainties related to the poor energy resolution, the small geometrical factor, and the high contamination by out‐of‐acceptance particles. In this work, the high‐quality data set from the Payload for Antimatter Matter Exploration and Light‐nuclei Astrophysics (PAMELA) space mission is used to calibrate the high‐energy (>80 MeV) proton channels of the EPEAD and the HEPAD sensors on board the GOES 13 and 15, bringing the measured spectral intensities inline with those registered by PAMELA. Suggested corrections significantly reduce the uncertainties on the response of GOES detectors, thus improving the reliability of the spectroscopic observations of solar energetic particle events.
Key Points
The high‐quality data of PAMELA are used to calibrate the high‐energy (>80 MeV) channels of the proton detectors on board of GOES 13 and 15
The effective energies of the two most energetic EPEAD channels are derived; results for both uncorrected and corrected fluxes are provided
The procedure is extended to the HEPAD channels, providing the first attempt to calibrate the HEPAD sensors with space‐based observations
Arriving at a medical diagnosis is a highly complex process that is extremely error prone. Missed or delayed diagnoses often lead to patient harm and missed opportunities for treatment. Since medical ...imaging is a major contributor to the overall diagnostic process, it is also a major potential source of diagnostic error. Although some diagnoses may be missed because of the technical or physical limitations of the imaging modality, including image resolution, intrinsic or extrinsic contrast, and signal-to-noise ratio, most missed radiologic diagnoses are attributable to image interpretation errors by radiologists. Radiologic interpretation cannot be mechanized or automated; it is a human enterprise based on complex psychophysiologic and cognitive processes and is itself subject to a wide variety of error types, including perceptual errors (those in which an important abnormality is simply not seen on the images) and cognitive errors (those in which the abnormality is visually detected but the meaning or importance of the finding is not correctly understood or appreciated). The overall prevalence of radiologists' errors in practice does not appear to have changed since it was first estimated in the 1960s. The authors review the epidemiology of errors in diagnostic radiology, including a recently proposed taxonomy of radiologists' errors, as well as research findings, in an attempt to elucidate possible underlying causes of these errors. The authors also propose strategies for error reduction in radiology. On the basis of current understanding, specific suggestions are offered as to how radiologists can improve their performance in practice.
The global importance of online advertising calls for a detailed understanding of consumer-specific responses to online ad repetitions. A key concern for advertisers is not only whether some ...consumers display degrees of "wearout" but also whether they can surpass a point at which additional exposures have a negative marginal effect: "weariness." The authors examine a large-scale advertising campaign aimed at driving viewers to a target website, which comprises more than 12,000 users across over 400 websites. These data are analyzed using a flexible discrete mixture specification that accommodates different response shapes over ad stock and timing and parcels ad viewers into response classes based on their internet usage metrics. The resulting classes display varying degrees of wearout, with one subgroup, accounting for about 24% of the sample, evincing weariness. The model also estimates differential publisher effectiveness, with the most effective publisher being nine times more effective than the one 26 places down. The authors demonstrate that the finding of weariness is robust to all the model's main components, with one key exception: heterogeneity in users' ad response. Analysis further suggests that an appropriate "profiling and capping" strategy can improve ad deployment by as much as 15% overall for these data.
Collectivist versus individualistic values are important attributes of intercultural variation. Collectivist values favour in-group members over out-group members and may have evolved to protect ...in-group members against pathogen transmission. As predicted by the pathogen stress theory of cultural values, more collectivist countries are associated with a higher historical pathogen burden. However, if lifestyles of collectivist countries indeed function as a social defence which decreases pathogen transmission, then these countries should also have experienced fewer disease outbreaks in recent times. We tested this novel hypothesis by correlating the values of collectivism-individualism for 66 countries against their historical pathogen burden, recent number of infectious disease outbreaks and zoonotic disease outbreaks and emerging infectious disease events, and four potentially confounding variables. We confirmed the previously established negative relationship between individualism and historical pathogen burden with new data. While we did not find a correlation for emerging infectious disease events, we found significant positive correlations between individualism and the number of infectious disease outbreaks and zoonotic disease outbreaks. Therefore, one possible cost for individualistic cultures may be their higher susceptibility to disease outbreaks. We support further studies into the exact protective behaviours and mechanisms of collectivist societies which may inhibit disease outbreaks.
The idea of programmable networks has recently re-gained considerable momentum due to the emergence of the Software-Defined Networking (SDN) paradigm. SDN, often referred to as a "radical new idea in ...networking", promises to dramatically simplify network management and enable innovation through network programmability. This paper surveys the state-of-the-art in programmable networks with an emphasis on SDN. We provide a historic perspective of programmable networks from early ideas to recent developments. Then we present the SDN architecture and the OpenFlow standard in particular, discuss current alternatives for implementation and testing of SDN-based protocols and services, examine current and future SDN applications, and explore promising research directions based on the SDN paradigm.
Over the course of evolution, organism size has diversified markedly. Changes in size are thought to have occurred because of developmental, morphological and/or ecological pressures. To perform ...phylogenetic tests of the potential effects of these pressures, here we generated a dataset of more than ten thousand descriptions of insect eggs, and combined these with genetic and life-history datasets. We show that, across eight orders of magnitude of variation in egg volume, the relationship between size and shape itself evolves, such that previously predicted global patterns of scaling do not adequately explain the diversity in egg shapes. We show that egg size is not correlated with developmental rate and that, for many insects, egg size is not correlated with adult body size. Instead, we find that the evolution of parasitoidism and aquatic oviposition help to explain the diversification in the size and shape of insect eggs. Our study suggests that where eggs are laid, rather than universal allometric constants, underlies the evolution of insect egg size and shape.
The quantum Rabi model describing the fundamental interaction between light and matter is a cornerstone of quantum physics. It predicts exotic phenomena like quantum phase transitions and ...ground-state entanglement in ultrastrong and deep-strong coupling regimes, where coupling strengths are comparable to or larger than subsystem energies. Demonstrating dynamics remains an outstanding challenge, the few experiments reaching these regimes being limited to spectroscopy. Here, we employ a circuit quantum electrodynamics chip with moderate coupling between a resonator and transmon qubit to realise accurate digital quantum simulation of deep-strong coupling dynamics. We advance the state of the art in solid-state digital quantum simulation by using up to 90 second-order Trotter steps and probing both subsystems in a combined Hilbert space dimension of ∼80, demonstrating characteristic Schrödinger-cat-like entanglement and large photon build-up. Our approach will enable exploration of extreme coupling regimes and quantum phase transitions, and demonstrates a clear first step towards larger complexities such as in the Dicke model.
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