Ultrafast angle-resolved XUV photoemission reveals the time- and momentum-dependent electronic structure of 1T-TaS2, a hybrid Mott and charge-density-wave insulator. Both electronic orderings melt ...well before the lattice responds, suggesting that electronic correlations play a role not just in the Mott localization but in the CDW ordering as well.
Transforming growth factor (TGF)-β is a potent regulator of growth and differentiation in normal squamous epithelium. TGF-β
exerts its antiproliferative effect via the TGF-β type II receptor ...(TβR-II). A decrease in TβR-II expression is believed to
be responsible, in part, for the resistance of squamous cell carcinoma (SqCC) to the antiproliferative effects of TGF-β. In
the present study, we used immunohistochemistry and in situ hybridization to analyze the expression of TβR-II along the successive oncogenic stages of head and neck squamous neoplasia,
from normal epithelium to dysplasia to carcinoma. Quantitation of TβR-II expression in 38 SqCCs was assessed on a visual scale
ranging from negative (absence of staining) to 3+ (strong staining). Normal squamous epithelium and squamous epithelium in
the vicinity of the tumors showed homogenous receptor expression with moderate intensity. Dysplastic epithelium and carcinoma
in situ showed a mild decrease in receptor expression intensity. Well-differentiated to moderately differentiated carcinomas showed
heterogeneous expression of variable intensity, and poorly differentiated carcinomas were completely devoid of TβR-II. In
every tumor, the superficial component showed more intense receptor expression than the invasive component. These results
indicate that TβR-II expression inversely correlates with disease aggressiveness and suggest that aberrant TβR-II expression
is a contributing factor to the pathogenesis of SqCC.
This two-phase action research examined the profile and knowledge level of Grade III pupils about their knowledge on the distinct local vocabularies in order to formulate enrichment or intervention, ...to address any deficiency or lack of, and to assess whether such enrichment programs are effective for authentic, localized implementation of the MTB-MLE. The research instruments used in the first phase included survey and vocabulary assessment test. The researchers initially employed descriptive statistics to interpret the result. Majority of the respondents have established residency in Lopez, Quezon for at least four years. All of the pupils speak Tagalog only at home. The first phase of the research revealed that the pupils of Lopez West Elementary School Bldg. 1 performed satisfactorily in the language test. Most of them found that the most difficult words are generally content words. The initial results of this study serve as baseline information implying that the pupils’ level of understanding of the Lopezeños words needs enhancement and/or reinforcements; hence, there is an urgent need to implement the 2
cycle of this action research. The second phase once implemented seeks to evaluate the effectiveness of the intervention and/or enrichment activities that may guide language teachers in the conduct of classroom-based, culturally sensitive, contextualized language instruction.
P53-based immunization is an attractive approach to cancer immunotherapy due to the accumulation of p53 protein in tumor, but not in normal cells. However, it was not known whether immune response ...against self-protein (p53) could be generated in vivo. Mouse dendritic cells (DCs) were transduced with adenoviral construct containing murine full-length wild-type p53 (Ad-p53). Repeated immunizations with these cells protected 60% of mice against challenge with MethA sarcoma cells bearing point mutations in p53 gene. Activation of DCs via ligation of CD40 significantly improved the results of immunization: all mice were protected against MethA sarcoma. The treatment of MethA tumor-bearing mice with activated Ad-p53-transduced DCs showed complete tumor rejection in four out of six mice. The specificity of antitumor immune response was confirmed by CTL assay. The analysis of phenotype and function of DCs demonstrated that the effect of CD40 ligation on these cells was enhanced by their infection with Ad-p53. The level of neutralizing anti-adenovirus antibody was moderately elevated in these mice. No signs of autoimmune reaction were evident during detailed pathological evaluation of treated mice. These data demonstrate that activated Ad-p53-infected DCs are able to break tolerance to this protein and can be used in immunotherapy of cancer.
We have explored the spin polarisation of excited electrons in amorphous ferromagnetic iron-boron alloy by spin-resolved two-photon photoemission. These measurements were carried out with a spin ...resolved electron Time-of-Flight (ToF) analyser combined to a femtosecond laser source. The low kinetic energy was probed by caesium preparation of the sample surface. A constant spin polarisation of 18% was measured in the energy region between 1.3 and 3.2 eV above the Fermi level. The magnetic properties of the sample were characterised by a spin-resolved square hysteresis loop.
In this paper, the Langmuir–Freundlich isotherm (LF) is used to characterise a propazine-imprinted polymer obtained by precipitation polymerisation (MIP-P). Different rebinding studies were carried ...out allowing to explain the different interactions taking place between the molecularly imprinted polymer and six triazinic herbicides (desisopropylatrazine, desethylatrazine, simazine, atrazine, propazine and prometryn). The LF fitting parameters obtained (total number of binding sites, heterogeneity index and mean binding affinity) were compared to those obtained in a previous work for a propazine-imprinted polymer prepared by bulk polymerisation (MIP-B). From that study, it was concluded that precipitation polymerisation yielded polymers with a more homogeneous binding site distribution and higher affinity constants.
PDF
