Far-reaching changes to the structure and function of the Earth's natural systems represent a growing threat to human health. And yet, global health has mainly improved as these changes have gathered ...pace. What is the explanation? As a Commission, we are deeply concerned that the explanation is straightforward and sobering: we have been mortgaging the health of future generations to realise economic and development gains in the present.
We present a new limit on the production of a light dark-force mediator with the KLOE detector at DAΦNE. This boson, called U, has been searched for in the decay ϕ→ηU, U→e+e−, analyzing the decay ...η→π0π0π0 in a data sample of 1.7 fb−1. No structures are observed in the e+e− invariant mass distribution over the background. This search is combined with a previous result obtained from the decay η→π+π−π0, increasing the sensitivity. We set an upper limit at 90% C.L. on the ratio between the U boson coupling constant and the fine structure constant of α′/α<1.7×10−5 for 30<MU<400 MeV and α′/α⩽8×10−6 for the sub-region 50<MU<210 MeV. This result assumes the Vector Meson Dominance expectations for the ϕηγ⁎ transition form factor. The dependence of this limit on the transition form factor has also been studied.
The existence of a light dark force mediator has been tested with the KLOE detector at DAΦNE. This particle, called U, is searched for using the decay chain ϕ→ηU, η→π+π−π0, U→e+e−. No evidence is ...found in 1.5 fb−1 of data. The resulting exclusion plot covers the mass range 5<MU<470 MeV, setting an upper limit on the ratio between the U boson coupling constant and the fine structure constant, α′/α, of ⩽2×10−5 at 90% C.L. for 50<MU<420 MeV.
A
bstract
Using 1.63 fb
−1
of integrated luminosity collected by the KLOE experiment about 7 × 10
4
K
S
→
π
±
e
∓
ν
decays have been reconstructed. The measured value of the charge asymmetry for this ...decay is
A
S
= (−4.9 ± 5.7
stat
± 2.6
syst
) × 10
−3
, which is almost twice more precise than the previous KLOE result. The combination of these two measurements gives
A
S
= (−3.8 ± 5.0
stat
± 2.6
syst
) × 10
−3
and, together with the asymmetry of the
K
L
semileptonic decay, provides significant tests of the
CPT
symmetry. The obtained results are in agreement with
CPT
invariance.
Neutral kaon pairs produced in ϕ decays in anti-symmetric entangled state can be exploited to search for violation of CPT symmetry and Lorentz invariance. We present an analysis of the CP-violating ...process ϕ→KSKL→π+π−π+π− based on 1.7 fb−1 of data collected by the KLOE experiment at the Frascati ϕ-factory DAΦNE. The data are used to perform a measurement of the CPT-violating parameters Δaμ for neutral kaons in the context of the Standard Model Extension framework. The parameters measured in the reference frame of the fixed stars are:Δa0=(−6.0±7.7stat±3.1syst)×10−18 GeV,ΔaX=(0.9±1.5stat±0.6syst)×10−18 GeV,ΔaY=(−2.0±1.5stat±0.5syst)×10−18 GeV,ΔaZ=(3.1±1.7stat±0.5syst)×10−18 GeV. These are presently the most precise measurements in the quark sector of the Standard Model Extension.
Abstract Non-Technical Summary Despite growing recognition of the importance of transdisciplinary research in addressing complex sustainability challenges, in practice it has been much hampered by ...persistent inequities, power disparities, and epistemological disconnect. Planetary health as an emerging field offers a unique lens highlighting the need for knowledge integration across the environment, health, and development (EHD) nexus. Drawing upon extensive analyses, including a meta-analysis of existing transdisciplinary frameworks, a literature review of practices in these fields, and a case study of a planetary health action research project in Indonesia and Fiji, we propose a framework to guide the design and implementation of transdisciplinary research. Technical Summary The proposed framework was iteratively designed, starting with existing frameworks, complemented by findings and practice recommendations from a literature review of 36 publications of recent transdisciplinary practices in the EHD fields and an in-depth case study of a planetary health research from Indonesian perspectives. The practice framework focuses on the stakeholder collaboration process, and emphasizes reflexivity and co-learning throughout all research phases: initiation (co-design); implementation (adaptive co-management), and monitoring and refinement (co-monitoring). Foundational considerations for stakeholder engagement could inform process design by reflecting on stakeholder contributions, interactions, integration, and expected outcomes. As suggested by development studies, and implicitly agreed upon but insufficiently elaborated within environment and health, attention to the local context of the research, mapping of power dynamics, and the values of equity and inclusivity are pertinent if research is to produce credible, relevant, and legitimate knowledge and outcomes. A renewed focus on addressing power equities can help ensure stakeholders' perspectives and interests are equally valued and potential solutions are not inadvertently excluded as a legacy of systemic power imbalance. The practice framework is most effectively applied in the initial process co-design, by process initiators and funders assessing proposals for international transdisciplinary research in power-diverse settings or resource-poor contexts. Social Media Summary How can researchers across diverse fields collaborate with renewed focus on power inequities to accelerate progress towards the Sustainable Development Goals?
This study aimed to evaluate the feasibility of switching from transrectal to transperineal prostate biopsy (TPPBx) by urologists with no previous experience with TPPBx. Material A monocentric ...clinical study with exhaustive and consecutive inclusions was conducted between January and November 2021, including 105 consecutive patients who underwent TPPBx performed by two senior urologists with no previous experience of TPPBx (GR, FB). Biopsies were performed under local anesthesia (LA) without antibioprophylaxis. The main objective was to assess the safety of this procedure. Adverse events were classified according to the Clavien-Dindo score. The secondary objectives were to assess the level of pain experienced during the different steps of the procedure using a numerating rating scale (NRS), the rate of clinically significant prostate cancer (csPCa) detected, and the level of anxiety using the Hospital Anxiety and Depression Scale (HAD).
No major complications (Clavien-Dindo score≥3) were reported. One patient presented with acute urinary retention (1%) and a urinary tract infection (1%). Other adverse events were hematuria (43%), hemospermia (23%), rectal bleeding (1%), perineal hematoma (3%), persistent perineal pain (5%), and de novo erectile dysfunction (2%). The median level of pain on NRS for the procedure was 2.00 (IQ: 1.00-4.00); it was 3.00 (IQ: 2.00-5.00) during LA and 3.00 (IQ: 2.00-5.00) during punctions. In anxious patients (HAD score>10), the level of pain during the procedure was 2.5 (IQ: 2.00-3.00). Overall, csPCa was detected in 63%.
TPPBx under LA without antibioprophylaxis provides few complications, an acceptable pain threshold, and a satisfactorily rate of csPCa detection, even if performed by urologists with no previous experience of TPPBx.
PURPOSEManagement of pregnancy and delivery in women with lower urinary tract reconstruction is challenging and the currently available literature is insufficient to guide clinical practice. We ...report pregnancy and delivery outcomes in this specific population. MATERIALS AND METHODSWe conducted a national multicenter retrospective study (16 centers) including 68 women with 96 deliveries between 1998 and 2019. These women had at least 1 successful pregnancy and delivery after augmentation enterocystoplasty, catheterizable channel creation and/or artificial urinary sphincter implantation. Maternal and fetal complications during pregnancy and delivery were reported, as well as postpartum functional outcomes, according to the delivery mode. The chi-square test and Student's t-test were used to compare categorical and continuous variables, respectively. RESULTSOverall 32% of reported pregnancies were complicated by febrile urinary tract infections, 13.5% by renal colic and 14.6% required upper urinary tract diversion. In addition, 10% of patients reported transient self-catheterization difficulties and 13.5% reported de novo or increased urinary incontinence. The preterm delivery rate was 35.3%. Elective C-section was performed in 61% of pregnancies. Twenty complications occurred during delivery (20%), including 19 during elective C-section. Urinary continence at 1 year was unchanged for 93.5% of deliveries. Delivery mode (p=0.293) and multiparity (p=0.572) had no impact on urinary continence. CONCLUSIONSIn this population C-section appeared to be associated with a high risk of complications. In the absence of any obstetric or neurological contraindications, vaginal delivery should be proposed as the first line option to the majority of these women.
The way we live in our cities Capon, Anthony G
Medical journal of Australia,
December 2007, Volume:
187, Issue:
11-12
Journal Article
Peer reviewed
During 2007, the human species became predominantly urban. Australia is highly urbanised, and health varies within Australian cities. Australian urban life is characterised by sedentariness, excess ...food intake, reliance on cars for transport, a high level of exposure to media and marketing messages, and a consumer culture. These characteristics are linked to obesity, diabetes, heart disease, some cancers, chronic respiratory disease, injury, depression and anxiety. The evolution of cities has been characterised as a four-stage process: poverty, industrial, consumption and eco-city. Each stage but the last has defining health disorders. Transition to healthy and sustainable cities requires infrastructure investment in new urban areas (including mass transit, education and health services), better conditions for walking and cycling, access to healthy food and encouragement of suburban economic development. There is a role for everyone in the transition to healthy and sustainable cities.
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