El megayacimiento de gas shale situado en la Patagonia argentina (segunda reserva mundial de recursos de gas shale y cuarta de petróleo shale) se ha transformado en el proyecto estrella, en un ...contexto de transición energética global que busca sustituir los combustibles fósiles y superar la crisis geopolítica derivada de la invasión rusa de Ucrania. ¿Qué es Vaca Muerta y cuáles son los proyectos en marcha?
The participation of “Yacimientos Petrolíferos Fiscales” (YPF SA nowadays) has contributed throughout 100 years of the argentine oil industry, to the economic, productive, and social development of ...the 24 subnational jurisdictions and, at the same time, has been useful as an emblem of social cohesion and construction of a national identity throughout our vast Nation.
Thus, YPF has performed, on the field, as the “captain” of the national team and has developed in every segment of the country’s hydrocarbon and energy industry, which is why it has become the omnipresent “Aleph”.
La participación de Yacimientos Petrolíferos Fiscales SE (hoy YPF SA) ha contribuido, a lo largo de 100 años de historia petrolera argentina, al desarrollo económico, productivo y social de las 24 jurisdicciones subnacionales, y al mismo tiempo ha servido de estandarte a la cohesión social y construcción de una identidad nacional a lo largo, a lo ancho y en lo profundo de nuestra vasta Nación. Así, YPF se ha desempeñado, en la cancha, como el “capitán” del equipo nacional y ha desplegado una actuación en todos los segmentos de la industria hidrocarburífera y energética del país, por lo que se ha convertido en el “Aleph” omnipresente allí donde miremos.
More than 20% of hospitalized patients with COVID-19 demonstrate ARDS requiring ICU admission. The long-term respiratory sequelae in such patients remain unclear.
What are the major long-term ...pulmonary sequelae in critical patients who survive COVID-19?
Consecutive patients with COVID-19 requiring ICU admission were recruited and evaluated 3 months after hospitalization discharge. The follow-up comprised symptom and quality of life, anxiety and depression questionnaires, pulmonary function tests, exercise test (6-min walking test 6MWT), and chest CT imaging.
One hundred twenty-five patients admitted to the ICU with ARDS secondary to COVID-19 were recruited between March and June 2020. At the 3-month follow-up, 62 patients were available for pulmonary evaluation. The most frequent symptoms were dyspnea (46.7%) and cough (34.4%). Eighty-two percent of patients showed a lung diffusing capacity of less than 80%. The median distance in the 6MWT was 400 m (interquartile range, 362-440 m). CT scans showed abnormal results in 70.2% of patients, demonstrating reticular lesions in 49.1% and fibrotic patterns in 21.1%. Patients with more severe alterations on chest CT scan showed worse pulmonary function and presented more degrees of desaturation in the 6MWT. Factors associated with the severity of lung damage on chest CT scan were age and length of invasive mechanical ventilation during the ICU stay.
Three months after hospital discharge, pulmonary structural abnormalities and functional impairment are highly prevalent in patients with ARDS secondary to COVID-19 who required an ICU stay. Pulmonary evaluation should be considered for all critical COVID-19 survivors 3 months after discharge.
The COVID-19 pandemic created tremendous challenges for health-care systems. Intensive care units (ICU) were hit with a large volume of patients requiring ICU admission, mechanical ventilation, and ...other organ support with very high mortality. The Centro de Investigación Biomédica en Red-Enfermedades Respiratorias (CIBERES), a network of Spanish researchers to investigate in respiratory disease, commissioned the current proposal in response to the Instituto de Salud Carlos III (ISCIII) call.
CIBERESUCICOVID is a multicenter, observational, prospective/retrospective cohort study of patients with COVID-19 admitted to Spanish ICUs. Several work packages were created, including study population and ICU data collection, follow-up, biomarkers and miRNAs, data management and quality.
This study included 6102 consecutive patients admitted to 55 ICUs homogeneously distributed throughout Spain and the collection of blood samples from more than 1000 patients. We enrolled a large population of COVID-19 ICU-admitted patients including baseline characteristics, ICU and MV data, treatments complications, and outcomes. The in-hospital mortality was 31%, and 76% of patients required invasive mechanical ventilation. A 3-6 month and 1 year follow-up was performed. Few deaths after 1 year discharge were registered. Low anti-SARS-CoV-2 S antibody levels predict mortality in critical COVID-19. These antibodies contribute to prevent systemic dissemination of SARS-CoV-2. The severity of COVID-19 impacts the circulating miRNA profile. Plasma miRNA profiling emerges as a useful tool for risk-based patient stratification in critically ill COVID-19 patients.
We present the methodology used in a large multicenter study sponsored by ISCIII to determine the short- and long-term outcomes in patients with COVID-19 admitted to more than 50 Spanish ICUs.
La pandemia de COVID-19ha supuesto un enorme reto para los sistemas sanitarios. Las unidades de cuidados intensivos (UCI) se han visto afectadas por un gran volumen de pacientes que requerían ingreso en la UCI, ventilación mecánica y otras asistencias de órganos con gran mortalidad. El Centro de Investigación Biomédica en Red-Enfermedades Respiratorias (CIBERES), una red de investigadores españoles para el estudio de enfermedades respiratorias, encargó la presente propuesta en respuesta a la convocatoria del Instituto de Salud Carlos III (ISCIII).
CIBERESUCICOVID es un estudio de cohortes multicéntrico, observacional, prospectivo/retrospectivo de pacientes con COVID-19 ingresados en UCI españolas. Se crearon varios paquetes de trabajo: población de estudio y recogida de datos en la UCI, seguimiento, biomarcadores y miRNA, gestión de datos y calidad.
Este estudio incluyó a 6.102 pacientes consecutivos ingresados en 55 UCI distribuidas homogéneamente por toda España, y se recogieron muestras de sangre de más de 1.000 pacientes. Se incluyó a una amplia población de pacientes ingresados en UCI de COVID-19, y se registraron las características basales, los datos de la UCI y la ventilación mecánica, las complicaciones de los tratamientos y los resultados. La mortalidad hospitalaria fue del 31%, y el 76% de los pacientes requirieron ventilación mecánica invasiva. Se realizó un seguimiento de 3-6 meses y de 1 año. Se registraron pocas muertes después del alta a 1 año. Las bajas cifras de anticuerpos anti-SARS-CoV-2 S predicen la mortalidad en la COVID-19 crítica. Estos anticuerpos contribuyen a prevenir la diseminación sistémica del SARS-CoV-2. La gravedad de la COVID-19 influye en el perfil de miRNA circulantes. El perfil de miRNA plasmático emerge como un dato útil para la estratificación basada en el riesgo de los pacientes con COVID-19 en estado crítico.
Se presenta la metodología utilizada en un gran estudio multicéntrico patrocinado por el ISCIII para determinar los resultados a corto y largo plazo en pacientes con COVID-19 ingresados en más de 50 UCI españolas.
We herein document a large collection of 108 2-amino-4,6-disubstituted-pyrimidine derivatives as potent, structurally simple, and highly selective A1AR ligands. The most attractive ligands were ...confirmed as antagonists of the canonical cyclic adenosine monophosphate pathway, and some pharmacokinetic parameters were preliminarilly evaluated. The library, built through a reliable and efficient three-component reaction, comprehensively explored the chemical space allowing the identification of the most prominent features of the structure–activity and structure–selectivity relationships around this scaffold. These included the influence on the selectivity profile of the aromatic residues at positions R4 and R6 of the pyrimidine core but most importantly the prominent role to the unprecedented A1AR selectivity profile exerted by the methyl group introduced at the exocyclic amino group. The structure–activity relationship trends on both A1 and A2AARs were conveniently interpreted with rigorous free energy perturbation simulations, which started from the receptor-driven docking model that guided the design of these series.
We herein document a large collection of 108 2-amino-4,6-disubstituted-pyrimidine derivatives as potent, structurally simple, and highly selective A
AR ligands. The most attractive ligands were ...confirmed as antagonists of the canonical cyclic adenosine monophosphate pathway, and some pharmacokinetic parameters were preliminarilly evaluated. The library, built through a reliable and efficient three-component reaction, comprehensively explored the chemical space allowing the identification of the most prominent features of the structure-activity and structure-selectivity relationships around this scaffold. These included the influence on the selectivity profile of the aromatic residues at positions R
and R
of the pyrimidine core but most importantly the prominent role to the unprecedented A
AR selectivity profile exerted by the methyl group introduced at the exocyclic amino group. The structure-activity relationship trends on both A
and A
ARs were conveniently interpreted with rigorous free energy perturbation simulations, which started from the receptor-driven docking model that guided the design of these series.
We herein document a large collection of 108 2-amino-4,6-disubstituted-pyrimidine derivatives as potent, structurally simple, and highly selective A(1)AR ligands. The most attractive ligands were ...confirmed as antagonists of the canonical cyclic adenosine monophosphate pathway, and some pharmacokinetic parameters were preliminarily evaluated. The library, built through a reliable and efficient three-component reaction, comprehensively explored the chemical space allowing the identification of the most prominent features of the structure-activity and structure-selectivity relationships around this scaffold. These included the influence on the selectivity profile of the aromatic residues at positions R-4 and R-6 of the pyrimidine core but most importantly the prominent role to the unprecedented A(1)AR selectivity profile exerted by the methyl group introduced at the exocyclic amino group. The structure-activity relationship trends on both A(1) and A(2A)ARs were conveniently interpreted with rigorous free energy perturbation simulations, which started from the receptor-driven docking model that guided the design of these series.
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Critical COVID-19 survivors have a high risk of respiratory sequelae. Therefore, we aimed to identify key factors associated with altered lung function and CT scan abnormalities at a ...follow-up visit in a cohort of critical COVID-19 survivors.
Multicenter ambispective observational study in 52 Spanish intensive care units. Up to 1327 PCR-confirmed critical COVID-19 patients had sociodemographic, anthropometric, comorbidity and lifestyle characteristics collected at hospital admission; clinical and biological parameters throughout hospital stay; and, lung function and CT scan at a follow-up visit.
The median p25–p75 time from discharge to follow-up was 3.57 2.77–4.92 months. Median age was 60 53–67 years, 27.8% women. The mean (SD) percentage of predicted diffusing lung capacity for carbon monoxide (DLCO) at follow-up was 72.02 (18.33)% predicted, with 66% of patients having DLCO<80% and 24% having DLCO<60%. CT scan showed persistent pulmonary infiltrates, fibrotic lesions, and emphysema in 33%, 25% and 6% of patients, respectively. Key variables associated with DLCO<60% were chronic lung disease (CLD) (OR: 1.86 (1.18–2.92)), duration of invasive mechanical ventilation (IMV) (OR: 1.56 (1.37–1.77)), age (OR per-1-SD (95%CI): 1.39 (1.18–1.63)), urea (OR: 1.16 (0.97–1.39)) and estimated glomerular filtration rate at ICU admission (OR: 0.88 (0.73–1.06)). Bacterial pneumonia (1.62 (1.11–2.35)) and duration of ventilation (NIMV (1.23 (1.06–1.42), IMV (1.21 (1.01–1.45)) and prone positioning (1.17 (0.98–1.39)) were associated with fibrotic lesions.
Age and CLD, reflecting patients’ baseline vulnerability, and markers of COVID-19 severity, such as duration of IMV and renal failure, were key factors associated with impaired DLCO and CT abnormalities.
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