Being a transcription factor, NF-κB regulates gene expressions involving cell survival and proliferation, drug resistance, metastasis, and angiogenesis. The activation of NF-κB plays a central role ...in the development of inflammation and cancer. Thus, the down-regulation of NF-κB may be an exciting target in prevention and treatment of cancer. NF-κB could act as a tumor activator or tumor suppressant decided by the site of action (organ). Polyphenols are widely distributed in plant species, consumption of which have been documented to negatively regulate the NF-κB signaling pathway. They depress the phosphorylation of kinases, inhibit NF-κB translocate into the nucleus as well as interfere interactions between NF-κB and DNA. Through inhibition of NF-κB, polyphenols downregulate inflammatory cascade, induce apoptosis and decrease cell proliferation and metastasis. This review highlights the anticancer effects of polyphenols on the basis of NF-κB signaling pathway regulation.
Este texto é parte de uma pesquisa mais ampla, aprovada pelo CNPq, que busca investigar as relações entre arte, comunicação, tecnologia e educação. A partir de autores que subsidiam a importância da ...renovação das posturas ligadas à educação e ao conhecimento, apresenta uma metodologia de pesquisa interativa e multilinguagem que, criada nos anos 1990, recebeu o nome de Foto Voz. Integrando registro de imagens fotográficas, reflexão e discussão de situações-problema, essa metodologia tem sido utilizada em pesquisas que visam a intervenção social, com propostas ligadas à cultura dos participantes, à sua percepção da realidade e à sua subjetividade.
Este texto trata dos obstáculos que impedem o público em geral diferenciar mensagens e informações da realidade que o cerca. Para isso, trabalhamos com duas ideias básicas: de um lado, os avanços da ...democracia no mundo ocidental e, de outro, o desenvolvimento dos meios de comunicação e a instituição da sociedade mediática. Apresenta-se o conflito que existe entre os mecanismos políticos republicanos e a liberdade de expressão, assim como entre os interesses do mercado e a informação. Analisando historicamente diferentes etapas desses conflitos, propõe- -se, na sociedade globalizada e conectada pela comunicação em rede, a luta pela democratização das mídias como forma de libertar o público da Caverna de Platão do mundo contemporâneo.
Resumo Este trabalho objetivou identificar, por meio de uma revisão sistemática de literatura, o que já se sabe sobre a relação entre ansiedade matemática (AM), família, estilo parental e status ...socioeconômico. As buscas foram realizadas nas bases eletrônicas Portal de Periódicos Capes e Web of Science, incluindo apenas artigos publicados de 2001 a 2020. Os aspectos mais relevantes nos artigos incluem fatores ambientais, comportamentais, afetivos, acadêmicos e econômicos. Nenhum deles apresentou discussões sobre o conceito de família em termos históricos, sociais e culturais. Discutimos que, ao trabalhar com os responsáveis na relação entre AM e família, lidamos com fatores de risco que predizem a AM. Consideramos a importância de fundamentos históricos e culturais que possibilitam construir uma postura caracterizada pela capacidade de ser na dinâmica da realidade e de interferir nessa dinâmica como tal.
Abstract This study aimed to identify, through a systematic literature review, what is already known about the relationship between mathematical anxiety (MA), family, parenting style and socioeconomic status. The searches were carried out in the electronic bases Portal de Periódicos Capes and Web of Science, including only articles published from 2001 to 2020. The most relevant aspects in the articles include environmental, behavioral, affective, academic and economic factors. None of the articles presented a discussion about the concept of family in historical, social and cultural terms. We discussed that, when working with parents and caregivers in the relationship between MA and family, we deal with risk factors that predict MA. We consider the importance of historical and cultural foundations that make it possible to build a posture characterized by the ability to be in the dynamics of reality and to interfere in this dynamic as such.
Resumen Este trabajo tuvo como objetivo identificar, por medio de una revisión sistemática de la literatura, lo que ya se sabe sobre la relación entre la ansiedad matemática (AM), la familia, el estilo parental y el status socioeconómico. Las búsquedas fueron realizadas en las bases de datos electrónicas Portal de Periódicos Capes y Web of Science, incluyendo únicamente artículos publicados entre 2001 y 2020. Los aspectos más relevantes en los artículos incluyen factores ambientales, conductuales, afectivos, académicos y económicos. Ninguno de los artículos presentó una discusión sobre el concepto de familia en términos históricos, sociales y culturales. Discutimos que, al trabajar con los responsables de la relación entre AM y familia, tratamos con factores de riesgo que predicen la AM. Consideramos la importancia de fundamentos históricos y culturales que posibiliten construir una postura caracterizada por la capacidad de estar en la dinámica de la realidad e interferir en esa dinámica como tal.
Résumé Cette étude vise à identifier, à travers une revue systématique de la littérature, ce qui est acquis sur la relation entre l’anxiété mathématique (AM), style parental et statut socio-économique. Les recherches, effectuées dans les bases de données électroniques Portal de Periódicos Capes et Web of Science, n’ont inclus que les articles publiés de 2001 à 2020 dont. Les aspects les plus pertinents concernent les facteurs environnementaux, comportementaux, affectifs, académiques et économiques. Aucun article n’a soulevé de discussion sur le concept de famille du point de vue historique, social et culturel. On discute que travailler avec les résponsables qui s’occupent de la relation entre l’anxiété mathématique et la famille permet d’identifier des facteurs de risque prédicteurs de cette anxiété. Il nous a semblé important de considérer quels étaient les fondements historiques et culturels qui favorisent construire une position caractérisée par la capacité d’être et d’interférer dans la dynamique de la réalité.
Two series of new chitosan derivatives were synthesized by reaction of deacetylated chitosan (CH) with propyl (CH-Propyl) and pentyl (CH-Pentyl) trimethylammonium bromides to obtain derivatives with ...increasing degrees of substitution (DS). The derivatives were characterized by 1H NMR and potentiometric titration techniques and their antifungal activities on the mycelial growth of Aspergillus flavus were investigated in vitro. The antifungal activities increase with DS and the more substituted derivatives of both series, CH-Propyl and CH-Pentyl, exhibited antifungal activities respectively three and six times higher than those obtained with commercial and deacetylated chitosan. The minimum inhibitory concentrations (MIC) were evaluated at 24, 48 and 72h by varying the polymer concentration from 0.5 to 16g/L and the results showed that the quaternary derivatives inhibited the fungus growth at polymer concentrations four times lower than that obtained with deacetylated chitosan (CH). The chitosans modified with pentyltrimethylammonium bromide exhibited higher activity and results are discussed taking into account the degree of substitution (DS).
Hair cortisol level has recently been identified as a promising marker for detecting long-term cortisol levels and a marker of hypothalamic-pituitary-adrenal cortex (HPA) axis activity. However, ...research on the association between obesity and an altered cortisol metabolism remains controversial.
This study aimed to investigate the relationship between hair cortisol levels and overweight and obesity in participants from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
This was a cross-sectional study involving 2,499 participants from the second follow-up (visit 3, 2017-2019) attending research centers in Rio de Janeiro and Rio Grande do Sul states. Hair samples were collected, and cortisol levels were analyzed using enzyme-linked immunosorbent assay (ELISA) kits. Cortisol levels were classified as low (< 40 pg/mg), medium (40-128 pg/mg), or high (> 128 pg/mg). The participants were classified as eutrophic, overweight, or obese according to their weight (kg) and height (m
). Odds ratios (ORs) with 95% confidence intervals (95%CI) were estimated.
Of the 2499 individuals, 30% had eutrophic weight, 40% were overweight, and 30% were obese. Notably, cortisol levels gradually increased with increasing body weight. Among participants with high hair cortisol levels, 41.2% were classified as overweight and 34.2% as obese. Multinomial logistic regression analysis indicated that participants with high cortisol levels were 43% (OR =1.43; 95%CI: 1.02-2.03) more likely to be overweight and 72% (OR =1.72; 95%CI:1.20-2.47) more likely to be obese than participants with low hair cortisol levels. After adjustment for all covariates, high cortisol levels remained associated with obesity (OR = 1.54; 95%CI:1.02-2.31) and overweight (OR =1.33; 95%CI:0.91-1.94).
In the ELSA-Brazil cohort, hair stress were positively associated with overweight and obesity. These results underscore the importance of considering stress and cortisol as potential factors in obesity prevention and intervention efforts, and highlight a novel aspect of the complex relationship between stress and obesity in the Brazilian population.
Este artigo trabalha com dois conceitos fundamentais, a educomunicação e a desinformação, procurando mostrar que a manipulação de informações e a influência das tecnologias de comunicação sobre a ...opinião pública têm sido uma preocupação central dos filósofos e estudiosos da comunicação humana. Assim, analisando a desinformação como fenômeno da atualidade, são apresentadas as principais teorias das ciências da comunicação que trazem subsídios para estudá-lo – de perspectivas diferentes, mas complementares. A partir dessa abordagem, questões como democracia, ideologia e poder se tornam elementos aglutinadores dessas análises.
Piping is an erosive process in which subsurface soil particles are removed, causing the formation of underground tunnels. A variety of physical and chemical factors control pipe formation. This ...study focused on hydrophysical soil properties to propose a mechanism to explain the piping process in soils in a tropical climate in Brazil. We observed two levels of pipes in the field: shallow pipes that form at the transition between E/B horizons (~0.30–0.45 m) and deep pipes that form between different Bt horizons (~1.50 m). We collected disturbed soil samples to determine the soil particle distribution and organic matter content, and undisturbed soil samples were collected to determine the hydrophysical attributes and for soil micromorphometric analysis. We found that the study area was prone to soil collapse and that physical properties controlled the process. The results showed a textural and structural gradient between the E and Bt horizons, where the Bt horizons presented a higher clay content and a well-developed structure (strong sub-angular blocks) compared to the essentially sandy E horizons (single grain). This gradient changed the soil porosity from macroporosity in the E horizon to microporosity in the Bt horizon, particularly represented by the decrease in complex pores. For deeper pipes, soil attribute gradients were found between different Bt horizons. A modification in the structure grade from moderate to weakly moderate, soil water retention curves with different slopes and shapes, and an increase in porosity correlating with soil depth, reflect an increase in larger complex pores. These changes in structure, texture, porosity, and pore type reflect the soil's hydraulic conductivity in the transition of different horizons, which can promote the accumulation and temporary stagnation of water at the top of the Bt horizons, and trigger the piping process when the lateral water flow reaches the critical flow velocity.
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•Two levels of pipes were detected: shallow (~0.30–0.45 m) and deep (~1.50 m) pipes.•Piping process is controlled mainly by soil structure, texture, and porosity.•Ksat reduction due to gradients in physical properties between horizons triggers piping.
O talk show na escola Giannini, Myrian Clark; Costa, Maria Cristina Castilho
Comunicação & educação,
11/2017, Volume:
22, Issue:
2
Journal Article
Peer reviewed
Open access
A passagem pelo ensino médio impõe aos jovens decisões, desafios e mudanças. No entanto, há um esvaziamento dos espaços de diálogo nas escolas. Nesta experiência – executada como monografia ...apresentada para obtenção do título de especialista em Educomunicação em 2015 –, alunos atuaram em grupo e desempenharam diferentes papéis na produção de um talk show, desfrutando de diálogos enriquecedores e de uma vivência do universo do trabalho e da pesquisa. Esse processo permitiu avaliar relacionamentos interpessoais, práticas educomunicativas, além de possibilitar a leitura crítica dos meios de comunicação e a ressignificação das informações do mundo complexo em que vivemos. As práticas educomunicativas da pesquisa foram registradas num diário de campo e somam forças para que outros educadores reflitam, renovem e ampliem a comunicação no ambiente escolar.
Diabetes is currently a worldwide health concern. Hyperglycemia, hypertension, obesity, and oxidative stress are the major risk factors that inevitably lead to all the complications from diabetes. ...These complications severely impact the quality of life of patients, and they can be managed, reduced, or even reverted by several polyphenols, plant extracts and foods rich in these compounds. The goal of this review is to approach diabetes not as a single condition but rather an interconnected combination of risk factors and complications. This work shows that polyphenols have multi target action and effects and they have been systematically proven to be relevant in the reduction of each risk factor and improvement of associated complication.
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