Xylella fastidiosa
is an important plant pathogen that attacks several plants of economic importance. Once restricted to the Americas, the bacterium, which causes olive quick decline syndrome, was ...discovered near Lecce, Italy in 2013. Since the initial outbreak, it has invaded 23,000 ha of olives in the Apulian Region, southern Italy, and is of great concern throughout Mediterranean basin. Therefore, predicting its spread and estimating the efficacy of control are of utmost importance. As data on this invasive infectious disease are poor, we have developed a spatially-explicit simulation model for
X. fastidiosa
to provide guidance for predicting spread in the early stages of invasion and inform management strategies. The model qualitatively and quantitatively predicts the patterns of spread. We model control zones currently employed in Apulia, showing that increasing buffer widths decrease infection risk beyond the control zone, but this may not halt the spread completely due to stochastic long-distance jumps caused by vector dispersal. Therefore, management practices should aim to reduce vector long-distance dispersal. We find optimal control scenarios that minimise control effort while reducing
X. fastidiosa
spread maximally—suggesting that increasing buffer zone widths should be favoured over surveillance efforts as control budgets increase. Our model highlights the importance of non-olive hosts which increase the spread rate of the disease and may lead to an order of magnitude increase in risk. Many aspects of
X. fastidiosa
disease invasion remain uncertain and hinder forecasting; we recommend future studies investigating quantification of the infection growth rate, and short and long distance dispersal.
Purpose: To examine the association of seizures with health‐related quality of life (HRQOL), physical and psychiatric comorbidities, and health behaviors.
Methods: We analyzed data obtained from ...adults aged 18 years or older (n = 30,445) who participated in the 2002 National Health Interview Survey, an ongoing, computer‐assisted personal interview of the noninstitutionalized U.S. population.
Results: An estimated 1.4% of adults 18 years or older reported being told by a health care professional that they had seizures. Persons with seizures were significantly more likely than those without seizures to report lower levels of education, higher levels of unemployment, pain, hypersomnia and insomnia, and psychological distress (e.g., feelings of sadness, nervousness, hopelessness, and worthlessness). In addition, they were significantly more likely to report insufficient leisure‐time physical activity as well as physical comorbidities such as cancer, arthritis, heart disease, stroke, asthma, severe headaches, lower back pain, and neck pain.
Conclusions: Our findings suggest that it is advisable for health care professionals to assess psychiatric and physical comorbidities among patients with a history of seizures potentially to improve patient health outcomes. Furthermore, public health surveillance systems should include questions on seizures, epilepsy, and mental health to better examine associations among these disorders and to better identify populations meriting further assessment and intervention.
Repeated biomass harvesting for human livelihood needs can cause significant changes in forest structure, composition and diversity. Such impacts have often been associated with the distance to ...villages and their size, but the effects of individual villages in relation to their characteristics have been little studied. Focussing on the issues around communities’ impacts on the forest, this research aimed to understand how resource extraction by two Buffer Zone villages in Nepal's Bardia National Park affects forest structure and diversity. Tree density, basal area, diameter at breast height (DBH), species richness, two diversity indices and disturbance indices were recorded in 108 plots in 12 transects, from March till May 2005, within the park along the village boundaries, where resource extraction occurs, and in the core park area which is isolated from human disturbance. Forest subject to resource extraction had a lower density of trees, smaller DBH and lower species richness and diversity. Forest disturbance declined with distance from the villages but the two villages differed widely in their impact on the forest. Resource use was more intensive in Shivapur village and percentage of trees lopped, average lopping intensity and numbers of dung piles were statistically significant. This was mainly due to the lack of access to Buffer Zone community Forest for Shivapur households. Interviews with villagers suggested that there have been changes in species availability compared to 5 years ago. Households also underestimated the impact of their resource extraction, which may prevent them from changing their behaviour to benefit conservation. It is clear that understanding rural communities’ needs, their framing of resource extraction and utilisation, and dependence on forest resources will be very helpful for long term conservation measures.
Plant pathogens are introduced to new geographical regions ever more frequently as global connectivity increases. Predicting the threat they pose to plant health can be difficult without in‐depth ...knowledge of behaviour, distribution and spread. Here, we evaluate the potential for using biological traits and phylogeny to predict global threats from emerging pathogens.
We use a species‐level trait database and phylogeny for 179 Phytophthora species: oomycete pathogens impacting natural, agricultural, horticultural and forestry settings. We compile host and distribution reports for Phytophthora species across 178 countries and evaluate the power of traits, phylogeny and time since description (reflecting species‐level knowledge) to explain and predict their international transport, maximum latitude and host breadth using Bayesian phylogenetic generalised linear mixed models.
In the best‐performing models, traits, phylogeny and time since description together explained up to 90%, 97% and 87% of variance in number of countries reached, latitudinal limits and host range, respectively. Traits and phylogeny together explained up to 26%, 41% and 34% of variance in the number of countries reached, maximum latitude and host plant families affected, respectively, but time since description had the strongest effect.
Root‐attacking species were reported in more countries, and on more host plant families than foliar‐attacking species. Host generalist pathogens had thicker‐walled resting structures (stress‐tolerant oospores) and faster growth rates at their optima. Cold‐tolerant species are reported in more countries and at higher latitudes, though more accurate interspecific empirical data are needed to confirm this finding.
Policy implications. We evaluate the potential of an evolutionary trait‐based framework to support horizon‐scanning approaches for identifying pathogens with greater potential for global‐scale impacts. Potential future threats from Phytophthora include Phytophthora x heterohybrida, P. lactucae, P. glovera, P. x incrassata, P. amnicola and P. aquimorbida, which are recently described, possibly under‐reported species, with similar traits and/or phylogenetic proximity to other high‐impact species. Priority traits to measure for emerging species may be thermal minima, oospore wall index and growth rate at optimum temperature. Trait‐based horizon‐scanning approaches would benefit from the development of international and cross‐sectoral collaborations to deliver centralised databases incorporating pathogen distributions, traits and phylogeny.
We evaluate the potential of an evolutionary trait‐based framework to support horizon‐scanning approaches for identifying pathogens with greater potential for global‐scale impacts. Potential future threats from Phytophthora include Phytophthora x heterohybrida, P. lactucae, P. glovera, P. x incrassata, P. amnicola and P. aquimorbida, which are recently described, possibly under‐reported species, with similar traits and/or phylogenetic proximity to other high‐impact species. Priority traits to measure for emerging species may be thermal minima, oospore wall index and growth rate at optimum temperature. Trait‐based horizon‐scanning approaches would benefit from the development of international and cross‐sectoral collaborations to deliver centralised databases incorporating pathogen distributions, traits and phylogeny.
Objective
There has been limited characterization of the burden of anxiety and depression, especially the former, among US adults with arthritis in the general population. The study objective was to ...estimate the prevalence and correlates of anxiety and depression among US adults with doctor‐diagnosed arthritis.
Methods
The study sample comprised US adults ages ≥45 years with doctor‐diagnosed arthritis (n = 1,793) from the Arthritis Conditions Health Effects Survey (a cross‐sectional, population‐based, random‐digit–dialed telephone interview survey). Anxiety and depression were measured using separate and validated subscales of the Arthritis Impact Measurement Scales. Prevalence was estimated for the sample overall and stratified by subgroups. Associations between correlates and each condition were estimated with prevalence ratios and 95% confidence intervals using logistic regression models.
Results
Anxiety was more common than depression (31% and 18%, respectively); overall, one‐third of respondents reported at least 1 of the 2 conditions. Most (84%) of those with depression also had anxiety. Multivariable logistic regression modeling failed to identify a distinct profile of characteristics of those with anxiety and/or depression. Only half of the respondents with anxiety and/or depression had sought help for their mental health condition in the past year.
Conclusion
Despite the clinical focus on depression among people with arthritis, anxiety was almost twice as common as depression. Given their high prevalence, their profound impact on quality of life, and the range of effective treatments available, we encourage health care providers to screen all people with arthritis for both anxiety and depression.
Background and purpose: Sleep-related problems, which affect 50–70 million Americans, involve all areas of life, including cognitive performance, emotional well-being, work and leisure-time ...activities, and general physical and mental well-being. We examined the association of insufficient sleep with health-related quality of life (HRQOL) and health behaviors.
Patients and methods: Data were obtained from the Behavioral Risk Factor Surveillance System, an ongoing, state-based, random-digit telephone survey of the non-institutionalized US population aged ≥18 years. In 2002, HRQOL measures were administered in 18 states and the District of Columbia, yielding complete responses to questions regarding sleep and demographic characteristics from 98% of study participants (
n=79,625).
Results: An estimated 26% of adults reported frequent (≥14 days in the past 30 days) sleep insufficiency. They were significantly more likely than those without frequent sleep insufficiency to report fair/poor general health, frequent physical distress, frequent mental distress, activity limitations, depressive symptoms, anxiety, and pain. In addition, they were significantly more likely to smoke, to be physically inactive, to be obese, and, among men, to drink heavily.
Conclusion: Insufficient sleep is associated with a variety of adverse health behaviors and impairment in all HRQOL domains investigated. Accordingly, assessment of sleep appears to be an important component of general medical care. Moreover, expanded assessment of sleep in the general population may provide a better understanding of prevalence of impaired sleep and its many implications.
The impact of climate change on social conflict and violence is of increasing concern. The significant risk that climate change poses for human conflict has driven scholars to investigate the ...processes underlying the relationship. Although climate change may not directly cause conflict, heat waves and extreme weather events could amplify interpersonal violence, and climate change consequences (i.e. economic deprivation and migration) could also intensify intergroup conflict. However, psychological research is weakly integrated with this literature, and interdisciplinary efforts are needed to uncover the underpinnings of the relationship between climate change and conflict. In particular, psychological research on intergroup threat, climate change mitigation and adaptation, and culture can provide valuable insights into understanding and responding to climate-induced conflict.
•Climatic variation is linked to increases in interpersonal and intergroup conflict.•The link between climate change and conflict is heavily context dependent.•Climate change will cause conflict through both direct and indirect pathways.•Adaptation interventions may reduce the impact of climate change on conflict.
Abstract Understanding family forest owner (FFO) estate planning decisionmaking is fundamental to ensuring the survival of landscapes that provide many public goods, but little is known about how ...land-based estate planning differs by gender. Analyses of a survey of FFOs in northeastern United States indicated that female FFOs rate themselves with lower levels of land-based estate planning self-efficacy—being less prepared, confident, and financially able to move forward with planning the future of their land than males. Of the FFOs who had positive levels of land-based estate planning self-efficacy, females were more likely to want to keep their land undeveloped than males. Our research suggests that increasing land-based estate planning self-efficacy of female FFOs may lead to higher rates of keeping land undeveloped for regions with FFOs similar to those of the northeast. We recommend ways in which foresters and programs could play an important role in increasing land-based estate planning self-efficacy.
Protein folding within the endoplasmic reticulum is assisted by molecular chaperones and folding catalysts that include members of the protein-disulfide isomerase and peptidyl-prolyl isomerase ...families. In this report, we examined the contributions of the cyclophilin subset of peptidyl-prolyl isomerases to protein folding and identified cyclophilin C as an endoplasmic reticulum (ER) cyclophilin in addition to cyclophilin B. Using albumin and transferrin as models of cis-proline-containing proteins in human hepatoma cells, we found that combined knockdown of cyclophilins B and C delayed transferrin secretion but surprisingly resulted in more efficient oxidative folding and secretion of albumin. Examination of the oxidation status of ER protein-disulfide isomerase family members revealed a shift to a more oxidized state. This was accompanied by a >5-fold elevation in the ratio of oxidized to total glutathione. This “hyperoxidation” phenotype could be duplicated by incubating cells with the cyclophilin inhibitor cyclosporine A, a treatment that triggered efficient ER depletion of cyclophilins B and C by inducing their secretion to the medium. To identify the pathway responsible for ER hyperoxidation, we individually depleted several enzymes that are known or suspected to deliver oxidizing equivalents to the ER: Ero1αβ, VKOR, PRDX4, or QSOX1. Remarkably, none of these enzymes contributed to the elevated oxidized to total glutathione ratio induced by cyclosporine A treatment. These findings establish cyclophilin C as an ER cyclophilin, demonstrate the novel involvement of cyclophilins B and C in ER redox homeostasis, and suggest the existence of an additional ER oxidative pathway that is modulated by ER cyclophilins.
The purpose of this study was to assess the relation of adverse childhood experiences (ACEs), including abuse, neglect, and household dysfunction, to the risk of ischemic heart disease (IHD) and to ...examine the mediating impact on this relation of both traditional IHD risk factors and psychological factors that are associated with ACEs.
Retrospective cohort survey data were collected from 17,337 adult health plan members from 1995 to 1997. Logistic regression adjusted for age, sex, race, and education was used to estimate the strength of the ACE-IHD relation and the mediating impact of IHD risk factors in this relation. Nine of 10 categories of ACEs significantly increased the risk of IHD by 1.3- to 1.7-fold versus persons with no ACEs. The adjusted odds ratios for IHD among persons with > or =7 ACEs was 3.6 (95% CI, 2.4 to 5.3). The ACE-IHD relation was mediated more strongly by individual psychological risk factors commonly associated with ACEs than by traditional IHD risk factors. We observed significant association between increased likelihood of reported IHD (adjusted ORs) and depressed affect (2.1, 1.9 to 2.4) and anger (2.5, 2.1 to 3.0) as well as traditional risk factors (smoking, physical inactivity, obesity, diabetes and hypertension), with ORs ranging from 1.2 to 2.7.
We found a dose-response relation of ACEs to IHD and a relation between almost all individual ACEs and IHD. Psychological factors appear to be more important than traditional risk factors in mediating the relation of ACEs to the risk of IHD. These findings provide further insights into the potential pathways by which stressful childhood experiences may increase the risk of IHD in adulthood.
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