This paper provides an overview of Scalable High efficiency Video Coding (SHVC), the scalable extensions of the High Efficiency Video Coding (HEVC) standard, published in the second version of HEVC. ...In addition to the temporal scalability already provided by the first version of HEVC, SHVC further provides spatial, signal-to-noise ratio, bit depth, and color gamut scalability functionalities, as well as combinations of any of these. The SHVC architecture design enables SHVC implementations to be built using multiple repurposed single-layer HEVC codec cores, with the addition of interlayer reference picture processing modules. The general multilayer high-level syntax design common to all multilayer HEVC extensions, including SHVC, MV-HEVC, and 3D HEVC, is described. The interlayer reference picture processing modules, including texture and motion resampling and color mapping, are also described. Performance comparisons are provided for SHVC versus simulcast HEVC and versus the scalable video coding extension to H.264/advanced video coding.
•Domestic cooking methods on phytochemicals and antioxidant activity were systemic evaluated.•Stir-frying and air frying on phytochemicals and antioxidant were first studied.•Antioxidant activity was ...well accordance with total phenolic while showed least accordance with vitamin C.
The effects of domestic cooking methods (boiling, baking, steaming, microwaving, frying, and stir-frying) and a new cooking method (air-frying) on the composition of phytochemicals (phenolics, anthocyanins, and carotenoids) and the antioxidant activity in purple-fleshed potatoes were investigated. Compared with raw potatoes, reductions of 23.59–90.42%, 7.09–72.44%, 7.45–83.15%, and 20.15–76.16% in the vitamin C, total phenolic, anthocyanin and carotenoid contents, respectively, was observed after cooking. Decreases of 7.88%, 21.55%, 22.48, 6.31%, and 61.38% in DPPH radical-scavenging activity was also observed after boiling, steaming, baking, microwaving and stir-frying, respectively, whereas an increase of 30.52% was noted after air-frying. A correlation analysis revealed that the antioxidant activity was in accordance with the total phenolic content and that this activity showed the lowest correlation with the vitamin C content. Among all of the cooking methods investigated in this study, stir-frying retained only slight levels of the phytochemicals and antioxidant activity observed in raw potatoes, whereas steaming and microwaving were able to retain most of the health-promoting compounds found in raw potatoes and may thus be suitable methods for cooking potatoes.
Cross-component linear model (CCLM) for chroma intra-prediction is a promising coding tool in the joint exploration model (JEM) developed by the Joint Video Exploration Team (JVET). CCLM assumes a ...linear correlation between the luma and chroma components in a coding block. With this assumption, the chroma components can be predicted by the linear model (LM) mode, which utilizes the reconstructed neighboring samples to derive parameters of a linear model by linear regression. This paper presents three new methods to further improve the coding efficiency of CCLM. First, we introduce a multi-model CCLM (MM-CCLM) approach, which applies more than one linear model to a coding block. With MM-CCLM, reconstructed neighboring luma and chroma samples of the current block are classified into several groups, and a particular set of linear model parameters is derived for each group. The reconstructed luma samples of the current block are also classified to predict the associated chroma samples with the corresponding linear model. Second, we propose a multi-filter CCLM (MF-CCLM) technique, which allows the encoder to select the optimal down-sampling filter for the luma component with the 4:2:0 color format. Third, we present an LM-angular prediction method, which synthesizes the angular intra-prediction and the MM-CCLM intra-prediction into a new chroma intra-coding mode. Simulation results show that the BD-rate savings of 0.55%, 4.66%, and 5.08% on average for Y, Cb, and Cr components, respectively, are achieved in all intra-configurations with the proposed three methods. MM-CCLM and MF-CCLM have been adopted into the JEM by JVET.
•CAFs suppress the killing effect of PBMCs on lung cancer cells through PD-L1.•Exosomes derived from CAFs suppress the killing effect of PBMCs on lung cancer cells.•MiR-142-5p suppresses lung cancer ...development through regulating PD-L1 in vivo.
Cancer-associated fibroblasts (CAFs) are the most important stromal cells in the tumor microenvironment (TEM) and have been reported to regulate various cancer development. Exosomes are considered important elements involved in intercellular communication and TME regulation, while the potential function of CAFs in lung cancer immunosuppressive microenvironments remains unknown. CAFs-derived exosomes (CAFs-exo) and normal fibroblasts (NFs)-derived exosomes (NFs-exo) were isolated by ultra-centrifugation and characterized by transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA) and western blot analysis. A549 cells were co-cultured with peripheral blood mononuclear cells (PBMCs). Flow cytometry assay was performed to detect the killing role of PBMCs on A549 cells. Bioinformatics and luciferase reporter assays were used to analyze the relationship among microRNA (miRNA), long non-coding RNA (lncRNA) and target gene. BALB/c mice were used to construct the lung cancer model by subcutaneous injection. Programmed death ligand 1 (PD-L1) was up-regulated in lung cancer tissues and cells. PD-L1 also up-regulated in CAFs cell medium-mediated A549 cells. CAFs decreased PBMCs induced-cell apoptosis through increasing PD-L1 in A549 cells. Moreover, CAFs transferred exosomes to lung cancer cells to suppress the killing effect of PBMCs through up-regulating PD-L1. Using microarray assays, opa-interacting protein 5 antisense RNA 1 (OIP5-AS1) level was highly expressed in CAFs-exos. After treatment by CAFs-exos, miR-142-5p level was significantly down-regulated in A549 cells. OIP5-AS1 served as a sponge to target miR-142-5p and negatively regulated miR-142-5p expression in lung cancer cells. In addition, PD-L1 was a direct target of miR-142-5p. CAFs derived exosomal OIP5-AS1 reduced PBMCs induced-cell apoptosis and promoted tumor growth through decreasing miR-142-5p and up-regulating PD-L1. CAFs-derived exosomes suppressed the role of PBMCs induced-killing of lung cancer cells and promoted lung cancer progression by OIP5-AS1/ miR-142-5p/ PD-L1 axis, which provided a potential opportunity for diagnosis and treatment of lung cancer.
Throughout the past few decades, the separable discrete cosine transform (DCT), particularly the DCT type II, has been widely used in image and video compression. It is well-known that, under ...first-order stationary Markov conditions, DCT is an efficient approximation of the optimal Karhunen-Loève transform. However, for natural image and video sources, the adaptivity of a single separable transform with fixed core is rather limited for the highly dynamic image statistics, e.g., textures and arbitrarily directed edges. It is also known that non-separable transforms can achieve better compression efficiency for images with directional texture patterns, yet they are computationally complex, especially when the transform size is large. In order to achieve higher transform coding gains with relatively low-complexity implementations, we propose a joint separable and non-separable transform. The proposed separable primary transform, named enhanced multiple transform (EMT), applies multiple transform cores from a pre-defined subset of sinusoidal transforms, and the transform selection is signaled in a joint block level manner. Moreover, a non-separable secondary transform (NSST) method is proposed to operate in conjunction with EMT. Unlike the existing non-separable transform schemes which require excessive amounts of memory and computation, the proposed NSST efficiently improves coding gain with much lower complexity. Extensive experimental results show that the proposed methods, in a state-of-the-art video codec, such as high efficiency video coding, can provide significant coding gains (average 6.9% and 4.5% bitrate reductions for intra and random-access coding, respectively).
This paper presents an overview of the decoder-side motion vector refinement (DMVR) algorithm in the Versatile Video Coding (VVC) standard. The proposed DMVR algorithm aims to increase the prediction ...accuracy of the blocks coded in merge mode using the bilateral matching-based refinement method. Compared with previous decoder-side motion vector derivation approaches, the proposed method significantly increases the coding efficiency without signaling additional side information. Furthermore, the hardware implementation considerations of the DMVR design are particularly focused in this study. This paper details and analyzes the novel features of DMVR contributing to the increase in coding efficiency and the reduction in computational complexity and implementation difficulty. Experimental results based on the VVC test model version 8.0 demonstrate that average Bjøntegaard Delta rate savings of 0.80 % and 2.81 % are achieved for the "tool-off" and "tool-on" test configurations, respectively. Moreover, 4 % additional decoding time and negligible additional external memory bandwidth requirements of DMVR based on the common test conditions for VVC are reported.
Efficient representation and coding of fine-granular motion information is one of the key research areas for exploiting inter-frame correlation in video coding. Representative techniques towards this ...direction are affine motion compensation (AMC), decoder-side motion vector refinement (DMVR), and subblock-based temporal motion vector prediction (SbTMVP). Fine-granular motion information is derived at subblock level for all the three coding tools. In addition, the obtained inter prediction can be further refined by two optical flow-based coding tools, the bi-directional optical flow (BDOF) for bi-directional inter prediction and the prediction refinement with optical flow (PROF) exclusively used in combination with AMC. The aforementioned five coding tools have been extensively studied and finally adopted in the Versatile Video Coding (VVC) standard. This paper presents technical details of each tool and highlights the design elements with the consideration of typical hardware implementations. Following the common test conditions defined by Joint Video Experts Team (JVET) for the development of VVC, 5.7% bitrate reduction on average is achieved by the five tools. For test sequences characterized by large and complex motion, up to 13.4% bitrate reduction is observed. Additionally, visual quality improvement is demonstrated and analyzed.
Polysaccharides are considered to be the most important active substances in Goji. However, the structure of polysaccharides varies according to the extraction methods applied, and the solution used ...to prepare Goji polysaccharides (LBPs) were limited. Thus, it is important to clarify the connection between extraction methods and structure of Goji polysaccharide. In view of the complex composition of cell wall polysaccharides and the various forms of interaction, different extraction methods will release different parts of the cell wall. The present study compared the effects of different extraction methods, which have been used to prepare different types of plant cell wall polysaccharides based on various sources, on the structure of cell-wall polysaccharides from Goji, by the single separate use of hot water, hydrochloric acid (0.4%) and sodium hydroxide (0.6%), at both high and low temperatures. Meanwhile, in order to explore the limitations of single extraction, sequential extraction methods were applied. Structural analysis including monosaccharide analysis, GPC-MALLS, AFM and
H-NMR suggested the persistence of more extensively branched rhamnogalacturonan I (RG-I) domains in the procedures involving low-temperature-alkali, while procedures prepared by high-temperature-acid contains more homogalacturonan (HG) regions and results in the removal of a substantial part of the side chain, specifically the arabinan. A kind of acidic heteropolysaccharide was obtained by hot water extraction. SEC-MALLS and AFM confirmed large-size polymers with branched morphologies in alkali-extracted polysaccharides. Our results provide new insight into the extraction of Goji polysaccharides, which differ from the hot water extraction used by traditional Chinese medicine.
Pectin, a natural polysaccharide found in the cell wall of most higher plant such as citrus, has drawn much attention due to its potential beneficial role in facilitating the treatment of many ...diseases like cancer, hyper cholesterol and diabetes. However, the broad application of pectin faces great limitations as the large molecular size of pectin severely prevents its bioavailability in vivo. In this study, we report an effective and highly convenient approach to degrade natural pectin into lower molecular pectin. By combining ultrasound with Fenton system (US-Fenton), we show that ultrasound synergistically enhances the efficiency of Fenton reaction to degrade pectin into 5.5 kDa within only 35 minutes. Importantly, RG-I domain, the most effective portion of natural pectin, was well preserved and highly enriched. In addition, the antioxidant activities of US-Fenton-treated pectin was significantly elevated. The mechanism of this novel observation was further investigated through the multiple structural analyses including HPLC, IR and NMR. Taken together, we present a novel and convenient approach to generate ultra-low molecular weight pectin with high efficiency and higher bioactivity. We expect our approach will have broader applications in improving the bioavailability and bioactivity of other polysaccharide-based natural compounds.
Pectin had been recovered from canning wastewater produced by chemical treatment of segment membrane during preparation of canned citrus in our previous research. The purpose of this study was to ...characterize the extracted pectin from canning wastewater, and to evaluate its application as a fat alternative to replace fat in ice cream. The monosaccharide composition and rheological properties of the pectin were determined. The influences of fat reduction and pectin addition on the physicochemical, rheological and sensory properties of low-fat ice cream were determined. The rheological results showed that pectin solutions were typical pseudoplastic fluids. The addition of pectin in ice cream can cause an increase in viscosity, overrun, and hardness, and a decrease in meltdown of the ice cream. When 0.72% pectin (
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) is incorporated into ice cream, a prototype product of ice cream with 45% lower fat content compared to the control was made. Results indicated that their qualities such as appearance, flavor, and taste were not significantly different. The low-fat ice cream had higher smoothness scores and lower mouth-coating scores. Hence, pectin extracted from citrus canning wastewater can be potentially used as fat replacer in ice cream, which benefits both the environment and the food industry.
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