It is predicted that climate change characterized by global warming will adversely affect the rice. To study the impacts of future climate change on rice growth and yields are of significance to ...ensure world food supply.
This study aims to explore the growth and yield changes of double cropping rice in Southeast China, determine the key meteorological factors affecting the yield of double cropping rice and analyze the impact of planting date shifts on the phenology and yield of double cropping rice.
The phenology and yield of double cropping rice in the future was simulated based on Decision Support System for Agrotechnology Transfer (DSSAT) v4.7.5. The relationship between double cropping rice yield and meteorological factors is explored by using feature importance (IF) based on Random Forests model and copula entropy (CE). The impact of planting date shifts on phenology and yield of double cropping rice was determined by changing the planting date.
The result suggested that the yield of double cropping rice increased by 2.6%, 1.8%, −2.0% and 0.1% respectively under the scenarios for SSP1–2.6, SSP2–4.5, SSP3–7.0 and SSP5–8.5 when considered the effects of CO2. With the increase of radiative forcing, the precipitation (Pre) and solar radiation (SRAD) on yield of double cropping rice would become less and less important, and the importance of temperature on yield of double cropping rice would be greater and greater. Early planting of early rice and late planting of late rice will increase the length of phenology and yield of double cropping rice. However, the increased phenological length for early rice is mainly due to the increase for length of planting to anthesis (P-A), and late rice is due to the increase for length of anthesis to maturation (A-M). When the optimal planting date is adopted, the rice yield will increase by 4.6%, 5.4%, 3.4% and 10.2%, respectively.
This study provides adaptive measures and suggestions for local decision makers on how to deal with the impact of future climate change.
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•The simulation of future phenology and yield of double cropping rice is based on the latest CMIP6 data.•To determine the correlation based on Copula entropy.•Early planting of early rice and late planting of late rice are beneficial to increase yield.•The prolong for early rice phenology is caused by P-A and for late rice is the A-M.
Accurate identification of the spatio-temporal planting structure and analysis of its driving factors in an irrigation district are the important bases for scientific and reasonable utilization of ...irrigation water resources. In pursuit of this goal, the training sample migration method combined with the random forest algorithm were used to classify land use and planting structure over 2001–2022 in the lower Yellow River Basin. Moreover, an econometric regression model was applied to quantify the driving factors of the change in the crop-planted area. The results illustrated that the identification method has relatively high accuracy in identifying historical periods of land use and planting structures, with the average kappa coefficient equating to 0.953. From 2001 to 2022, the area of cultivated land was the largest, with the proportion of the total area increasing from 45.72% to 58.12%. The planted area of winter wheat–summer maize rotation increased from 74.84% to 88.11% of the cultivated land. While the planted area of cotton declined by 96.36%, about 50% of cotton planting was converted to the winter wheat–summer maize rotation planting. The government policies about grain purchase and storage were the dominant factors for the change in the crop-planted area. This resulted in an increase of 63.32 × 103 ha and 63.98 × 103 ha in the planted area of winter wheat and summer maize, respectively. The findings are of great significance to the allocation of water resources in irrigation districts of the lower Yellow River Basin.
Abstract
Background
Metabolic reprogramming refers to tumor-associated metabolic alterations during tumorigenesis and has been regarded as one of the most important features of cancer. Profiling the ...altered metabolites and lipids in hepatocellular carcinoma with spatial signature will not only enhance our understanding of tumor metabolic reprogramming, but also offer potential metabolic liabilities that might be exploited for hepatocellular carcinoma therapy.
Methods
We perform matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) analysis on both hepatocellular carcinoma xenograft mouse model and hepatocellular carcinoma patients. Discriminatory metabolites that altered during the development of hepatocellular carcinoma are screened and imaged in xenograft mouse model and are further validated in 21 hepatocellular carcinoma patients.
Results
We discover stepwise metabolic alterations and progressively increasing metabolic heterogeneity during the growth of hepatocellular carcinoma. Arginine and its metabolites spermine and spermidine, choline and phosphatidylcholine metabolism, and fatty acids were found to be significantly reprogrammed in hepatocellular carcinoma tissues.
Conclusions
The spatially resolved profiling of the metabolites and lipids in highly heterogeneous hepatocellular carcinoma tissue will contribute to obtaining precise metabolic information for the understanding of tumor metabolic reprogramming.
Cp*RuCl(PPh3)2 is an effective catalyst for the regioselective “fusion” of organic azides and terminal alkynes, producing 1,5-disubstituted 1,2,3-triazoles. Internal alkynes also participate in this ...catalysis, resulting in fully substituted 1,2,3-triazoles.
Hypercrosslinked polymers HCPs have been widely used as precursors to prepare porous carbon materials because of their highly ordered porous structure and large specific surface area. In this paper, ...we used a solvothermal method to prepare a hypercrosslinked polymer, and the HCPC-700-A was prepared using an activation method with the hypercrosslinked polymer as the precursor. The effects of different carbon–alkali ratios on the microstructure, composition and electrochemical properties of porous carbon HCP were studied. The results show that the surface of porous carbon HCPC-700-A presents a relatively regular geometric shape, and a large number of pore structures are mainly micro- and mesopores. The specific surface area is 2074.53 m2 g−1, and the average pore size is between 1.29 and 1.93 nm. Porous carbon HCPC-700-1:2 has excellent electrochemical performance in 1 M H2SO4, and the specific capacitance is up to 464.4 F g−1 at a current density of 1 A g−1. The specific capacitance decay rate is 29.72% when the current density is increased from 1 A g−1 to 8 A g−1. After 5000 cycles, the capacitance retention rate is 91.16% at a current density of 2 A g−1, showing excellent electrochemical performance, good cycle stability and perfect energy storage performance. This research provides new experimental ideas for HCPs in the electrochemical energy storage field.
Nuclear noncoding RNA (ncRNA) surveillance pathways play key roles in shaping the steady-state transcriptomes of eukaryotic cells. Defective and unneeded ncRNAs are primarily degraded by ...exoribonucleases that rely on protein cofactors to identify these RNAs. Recent studies have begun to elucidate both the mechanisms by which these cofactors recognize aberrant RNAs and the features that mark RNAs for degradation. One crucial RNA determinant is the presence of an accessible end; in addition, the failure of aberrant RNAs to fold into compact structures and assemble with specific binding proteins probably also contributes to their recognition and subsequent degradation. To date, ncRNA surveillance has been most extensively studied in budding yeast. However, mammalian cells possess nucleases and cofactors that have no known yeast counterparts, indicating that RNA surveillance pathways may be more complex in metazoans. Importantly, there is evidence that the failure of ncRNA surveillance pathways contributes to human disease.
Supercross-linked polymers are widely used as carbon precursor materials due to their abundant carbon sources and low cost. In this paper, a supercross-linked polymer was prepared by the solvothermal ...method. The supercross-linked polymer as a precursor and the PPyC-800-A was synthesized by activating this with KOH. The microstructure, structure, and electrochemical performances of porous carbon PPyC-800-A were studied at different of temperature and carbon alkali ratio. According to the results, the porous carbon PPyC-800-1:2 is mainly composed of a stack of spherical particles with a high surface area of 1427.03 m2 g−1, an average pore diameter of 2.32 nm, and a high specific capacitance of 217.7 F g−1 at a current density of 1.0 A g−1 in a 6 M KOH electrolyte. It’s retention rate is 97.58% after 5000 constant current charges and discharges. With a specific capacitance decay rate of 21.91 percent, an energy density of 11.96 Wh kg−1, and a power density of 500.0 W kg−1, the current density rises from 1.0 A g−1 to 10.0 A g−1, exhibiting remarkable electrochemical properties, cycling stability, and energy production performance This study contributes experimental ideas to the field of supercross-linked polymer-derived carbon materials and energy storage.
Palliative care might be beneficial to heart failure. However, the results remain controversial. We conducted a systematic review and meta-analysis to explore the effect of palliative care on heart ...failure.PubMed, Embase, Web of Science, EBSCO, and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of palliative care versus usual care on heart failure were included. Two investigators independently searched articles, extracted data, and assessed the quality of included studies. The primary outcome was readmission. Meta-analysis was performed using random-effect model.Five RCTs involving 545 patients were included in the meta-analysis. Overall, compared with control intervention, palliative care intervention was found to significantly reduce the readmission Std. mean difference = 0.79; 95% confidence intervals (CI) = 0.23 to 1.35; P = 0.006, Edmonton Symptom Assessment Scale (ESAS) (Std. mean difference = -2.5; 95% CI = -4.39 to -0.62; P = 0.009), and PHQ-9 (Std. mean difference = -1.16; 95% CI = -1.73 to -0.58; P < 0.005), as well as improve heart failure questionnaire (Std. mean difference = 4.46; 95% CI = 3.44 to 5.47; P < 0.005), but had no influence on mortality (RR = 1.54; 95% CI = 0.80 to 2.96; P = 0.19) and quality of life questionnaire (Std. mean difference = 1.81; 95% CI = -0.14 to 3.77; P = 0.07).Compared with control intervention, palliative care intervention was found to significantly reduce readmission, ESAS, PHQ-9, and improve heart failure questionnaire, but showed no influence on mortality and quality of life questionnaire in patients with heart failure.
Aim
To explore the effects of protein phosphatase 2 regulatory subunit B''Alpha (PPP2R3A) on the proliferation and migration of liver cancer cells.
Methods
Expression of PPP2R3A in tumor tissues of ...hepatocellular carcinoma (HCC) patients was detected by immunohistochemistry and western blotting. In two liver cancer cell lines (HepG2 and HuH7), PPP2R3A expression was silenced and then overexpression with PPP2R3A lentiviral vectors, and the effects of PPP2R3A knockdown or overexpression on the proliferation, cell cycle, migration, and invasion of HCC cells were determined in vitro. In a xenograft cancer model in nude mice, the in vivo effects of PPP2R3A knockdown on tumor growth and cancer cell proliferation were evaluated.
Results
PPP2R3A expression was found in tumor foci in six of eight HCC samples, at a level higher than that in the adjacent para‐tumor tissues. PPP2R3A expression was observed primarily in the cytoplasm of the cancer cells. Knockdown of PPP2R3A resulted in significant inhibition of hepatoma cell proliferation (P < .05), migration (P < .01), and invasion (P < .01) as well as a significant delay in the G1/S transition in both liver cancer lines (P < .05) and increased p53 expression. Conversely, overexpression of PPP2R3A promoted the proliferation (P < .05) and altered cell cycle progression (P < .05) of both liver cancer cell lines. In vivo, PPP2R3A knockdown in liver cancer cells led to significant reductions in the tumor volume (P < .001) and the expression of Ki‐67 in tumor tissues (P < .05).
Conclusion
PPP2R3A may play a role in liver cancer via the regulation of tumor cell proliferation and invasion.
The PPP2R3A may play a pro‐tumor function in HCC by regulating the proliferation and invasion of HCC cells.
Introduction: Aconitine is a highly toxic diterpenoid alkaloid, produced by plants of the Aconitum genus, that is still used in Chinese herbal medicines. Aconitine poisoning remains common in China ...and other parts of Asia. Case Report: A 48-year-old man received a diagnosis of aconitine poisoning after ingesting herbal medicinal wine made with caowu, which is made from Aconitum kusnezoffii roots, and was admitted to our hospital' s emergency department. Electrocardiography and thoracoabdominal computed tomography showed cardiovascular toxicity from aconitine poisoning along with polycystic renal hemorrhaging. Because the arrhythmia was not controlled with lidocaine, blood purification with a reduced dosage of heparin was performed to treat the arrhythmia and to avoid increasing the bleeding of the polycystic renal hemorrhage. The patient recovered from aconitine poisoning and polycystic kidney hemorrhage. Conclusions: This case significantly advances our understanding of hemoperfusion with reduced heparin for the treatment of ventricular arrhythmia caused by aconitine poisoning.
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