Metabolic syndrome is prevalent worldwide and its prevalence is related to physical activity, race, and lifestyle. Little data is available for people living in rural areas of China. In this study we ...examined associations of physical activity and sedentary behaviors with metabolic syndrome components among people in rural China.
The Nantong Metabolic Syndrome Study recruited 13,505 female and 6,997 male participants between 2007 and 2008. Data of socio-demographic characteristics and lifestyle were collected. The associations of physical activity and sedentary behaviors with metabolic syndrome components were analyzed.
Prevalence of metabolic syndrome was 21.6%. It was significantly lower in men than in women. Low risks of metabolic syndrome were observed in those who did less sitting and engaged in more vigorous physical activity. The highest tertile of vigorous physical activity was associated with 15-40% decreased odds of metabolic syndrome and all of its components, except for low high-density lipoprotein cholesterol in men. Women with the highest tertile of moderate physical activity had 15-30% lower odds of central obesity, high glucose, and high triglycerides compared with those in the lowest tertile. Sitting time >42 hours per week had a 4%-12% attributable risk of metabolic syndrome, central obesity, and high triglycerides in both genders, and abnormal glucose and diastolic blood pressure in women. Sleeping for more than 8 hours per day was associated with risk of high serum glucose and lipids.
Our data suggested that physical activity has a preventive effect against metabolic syndrome and all its abnormal components, and that longer sitting time and sleep duration are associated with an increased risk of metabolic syndrome components, including central obesity and high triglycerides, glucose, and diastolic blood pressure. This study could provide information for future investigation into these associations. Also, recommendations are developed to reduce prevalence of metabolic syndrome and its components in rural Chinese populations.
To explore a potential expansion of the phenotypic and genotypic characteristics of Finnish variant late-infantile neuronal ceroid lipofuscinosis (NCL), we screened a collection of 47 patients with ...clinically diagnosed NCL in whom no molecular diagnosis had been made.
We used PCR amplification of genomic DNA, followed by fluorescent-labeled dideoxy-nucleotide chain termination sequencing and multiplex ligation-dependent probe amplification, to screen our cohort of patients for mutations in CLN5. We collected ethnic background, clinical, and pathologic information, as available, to clarify the breadth of CLN5 disease expression and to explore possible genotype-phenotype correlations.
We identified 10 patients with pathogenic CLN5 mutations, including 11 mutations not previously described: 4 missense, 5 out-of-frame insertion/deletion mutations, and 2 large intragenic deletions. We also documented 3 previously reported CLN5 mutations. The age at disease onset in this cohort is predominantly juvenile rather than late infantile. Importantly, we have identified 2 adult-onset patients who share a common pathogenic allele. The majority of patients presented with motor and visual impairments and not seizures. In those patients with available longitudinal data, most had progressed to global neurodevelopmental and visual failure with seizures within 1 to 4 years.
Our study suggests that CLN5 mutations 1) are more common in patients with neuronal ceroid lipofuscinosis (NCL) than previously reported, 2) are found in non-Finnish NCL patients of broad ethnic diversity, and 3) can be identified in NCL patients with disease onset in adult and juvenile epochs. CLN5 genetic testing is warranted in a wider population with clinical and pathologic features suggestive of an NCL disorder.
The cross section of the e+e−→Λc+Λ¯c− process is measured with unprecedented precision using data collected with the BESIII detector at /¯s=4574.5, 4580.0, 4590.0 and 4599.5 MeV. The nonzero cross ...section near the Λc+Λ¯c− production threshold is cleared. At center-of-mass energies /¯s=4574.5 and 4599.5 MeV, the higher statistics data enable us to measure the Λc polar angle distributions. From these, the Λc electric over magnetic form-factor ratios (|GE/GM|) are measured for the first time. They are found to be 1.14±0.14±0.07 and 1.23±0.05±0.03, respectively, where the first uncertainties are statistical and the second are systematic.
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Background. A single administration of laninamivir octanoate, a long-acting neuraminidase inhibitor, against influenza infection has been proven effective in nonclinical studies. This study evaluated ...the clinical efficacy of laninamivir octanoate for the treatment of adult influenza patients. Methods. A double-blind, randomized controlled trial examined whether laninamivir octanoate was noninferior to oseltamivir. A total of 1003 patients aged ⩾20 years with febrile influenza symptoms for no more than 36 h were randomized to receive either 40 mg of laninamivir octanoate, 20 mg of laninamivir octanoate, or oseltamivir. Laninamivir octanoate was inhaled once on day 1, and oseltamivir (75 mg) was administered orally twice daily for 5 days. The primary end point was the time to illness alleviation. Results. A total of 996 patients were included in the primary analysis (40-mg laninamivir octanoate, n= 334; 20-mg laninamivir octanoate, n=326; and oseltamivir, n=336). The median time to illness alleviation in the 40-mg laninamivir octanoate, 20-mg laninamivir octanoate, and oseltamivir groups was 73.0, 85.8, and 73.6 h, respectively. The difference between laninamivir octanoate and oseltamivir was −0.6 h (95% confidence interval, −9.9 to 6.9 h) for the 40-mg group and 12.2 h (95% confidence interval, −1.5 to 17.2 h) for the 20-mg group. The upper limits of the 95% confidence intervals were less than the prespecified noninferiority margin (18 h). The proportion of patients shedding virus at day 3 was significantly lower in the 40-mg laninamivir octanoate group than in the oseltamivir group (P=.006). Conclusions. A single inhalation of laninamivir octanoate is effective for the treatment of seasonal influenza, including that caused by oseltamivir-resistant virus, in adults. Clinical trials registration. NCT00803595.
Based on an e+e− collision data sample corresponding to an integrated luminosity of 567 pb−1 taken at the center-of-mass energy of s=4.6 GeV with the BESIII detector, we measure the absolute ...branching fraction of the inclusive decay Λc+→Λ+X to be B(Λc+→Λ+X)=(38.2−2.2+2.8±0.9)% using the double-tag method, where X refers to any possible final state particles. In addition, we search for direct CP violation in the charge asymmetry of this inclusive decay for the first time, and obtain ACP≡B(Λc+→Λ+X)−B(Λ¯c−→Λ¯+X)/B(Λc+→Λ+X)+B(Λ¯c−→Λ¯+X)=(2.1−6.6+7.0±1.6)%, a statistically limited result with no evidence of CP violation.
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Using a data sample of ${e}^{+}{e}^{{-}}$ collisions corresponding to an integrated luminosity of $567\text{ }\text{ }{\mathrm{pb}}^{{-}1}$ collected at a center-of-mass energy of $\sqrt{s}=4.6\text{ ...}\text{ }\mathrm{GeV}$ with the BESIII detector, we measure the absolute branching fraction of the inclusive semileptonic ${\mathrm{{\Lambda}}}_{c}^{+}$ decay with a double-tag method. We obtain $\mathcal{B}({\mathrm{{\Lambda}}}_{c}^{+}{\rightarrow}X{e}^{+}{{\nu}}_{e})=(3.95\pm{}0.34\pm{}0.09)%$, where the first uncertainty is statistical and the second systematic. Using the known ${\mathrm{{\Lambda}}}_{c}^{+}$ lifetime and the charge-averaged semileptonic decay width of nonstrange charmed mesons (${D}^{0}$ and ${D}^{+}$), we obtain the ratio of the inclusive semileptonic decay widths $\mathrm{{\Gamma}}({\mathrm{{\Lambda}}}_{c}^{+}{\rightarrow}X{e}^{+}{{\nu}}_{e})/\overline{\mathrm{{\Gamma}}}(D{\rightarrow}X{e}^{+}{{\nu}}_{e})=1.26\pm{}0.12$.
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To obtain better performance of meteorological applications, it is necessary to distinguish radar echoes from meteorological and non-meteorological targets. After a comprehensive analysis of the ...computational efficiency and radar system characteristics, we propose a fuzzy logic method that is similar to the MetSignal algorithm; the performance of this method is improved significantly in weak-signal regions where polarimetric variables are severely affected by noise. In addition, post-processing is adjusted to prevent anomalous propagation at a far range from being misclassified as meteorological echo. Moreover, an additional fuzzy logic echo classifier is incorporated into post-processing to suppress misclassification in the melting layer. An independent test set is selected to evaluate algorithm performance, and the statistical results show an improvement in the algorithm performance, especially with respect to the classification of meteorological echoes in weak-signal regions.
Abstract P5-04-06: Withdrawn Katzenellenbogen, JA; Min, J; Kim, SH ...
Cancer research (Chicago, Ill.),
02/2019, Volume:
79, Issue:
4_Supplement
Journal Article
Peer reviewed
Abstract
This abstract was withdrawn by the authors.
Citation Format: Katzenellenbogen JA, Min J, Kim SH, Laws MJ, Zhao Y, Ziegler Y, Nelson ER, Shahoei SH, Chu D, Park BH, Katzenellenbogen BS. ...Withdrawn abstract. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P5-04-06.
We present the first amplitude analysis of the decay Ds+ → π+π0η . We use an e+e– collision data sample corresponding to an integrated luminosity of 3.19 fb–1 collected with the BESIII detector at a ...center-of-mass energy of 4.178 GeV. We observe for the first time the W -annihilation dominant decays Ds+ → a0 ( 980 ) +π0 and Ds+ → a0 ( 980 ) 0π+ . In addition, we measure the branching fraction of Ds+ → π+π0η with significantly improved precision.
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