Using phosphotungstic acid, tetraethyl ethylenebisphosphonate (L) and rare earth chloride as raw materials, a series of Keggin-type POM-based rare earth complexes were synthesized by a heating and ...stirring method: LnL
3
(H
2
O)PW
12
O
40
·CH
3
CN (
1-6
) (Ln = Dy, Ho, Er, Tm, Yb, Lu). The molecular structures of the complexes were determined by X-ray single-crystal diffraction, and the influence of weak forces on the molecular packing structures were studied by calculating the presence of hydrogen bonds inside the complexes using PLATON. By analyzing the experimental results, it is concluded that tetraethyl ethylenebisphosphonate is coordinated with rare earth ions through bidentate chelation, and POMs which are not involved in coordination exist as anions. Complexes
1-6
are three-dimensional supramolecular structures constructed by hydrogen bonds. Powder X-ray diffraction proved that the structures of the synthesized complexes are consistent with the results of single-crystal analysis, and the purity is high. Thermogravimetric analysis showed that the series of complexes have good thermal stability above 200 °C. Notably, the complexes
1-6
showed good photocatalytic degradation ability to methyl orange (MO) solution under UV irradiation; their degradation rate reached more than 95% within 15 min. The membrane material of complex
1
was successfully prepared by combining complex
1
with polyvinylidene fluoride (PVDF). Scanning electron microscopy (SEM) showed that complex
1
was supported on the surface of the PVDF film. For photocatalytic degradation of MO solution, the MO degradation rate reached 97.4% within 50 min. Compared with the powder-type catalyst, the degradation efficiency is lower, but the membrane material catalysis solves the problem of catalyst recovery and has better recyclable performance. Using the method of adding different active species scavengers, the mechanism of the photocatalytic reaction was studied. Finally, terahertz time-domain spectroscopy (THz-TDS) was performed, which provided a spectroscopic basis for the rapid detection of the weak forces contained in the complexes.
Rare earth complexes based on Keggin-type polyoxometalate for photocatalytic degradation of MO. The degradation rate reached more than 95% within 15 min.
The vigorous shoots and roots help to improve drought resistance and post-transplanting recovery in rice seedlings (
Oryza sativa
L.). Hundreds of loci related to root system have been identified ...recently, but little research has been done on shoot traits, and the relationship between roots and shoots development is also still unclear. The objective of this study was to identify associated loci for roots and shoots in rice seedlings as well as to screen pleiotropic QTLs involved in coordinated development of roots and shoots. Using mini core collection of 273 cultivated rice accessions and 280 simple-sequence repeat markers, we investigated six traits root length (RL), root thickness (RT), root weight (RW), shoot length (SL), shoot weight (SW) and ratio of root-to-shoot mass in seedlings. Study was performed in hydroponic medium and genetic analysis was performed by association mapping using general linear model (GLM) with population structure (Q) and mixed linear model (MLM) involving Q and familial relatedness (K). Two subgroups
indica
and
japonica
showed significant differences in RT, RW and SW. Maximum correlation was observed between RW and SW. Using GLM 65 QTLs for root and 43 QTLs associated with shoot traits were detected. Among them, seven QTLs were present between RL and RW and five common QTLs were detected between SL and SW with high phenotypic variation effects (PVEs). Two key pleiotropic QTLs were also identified involved in collaborative development of roots and shoots in rice seedlings. Importantly, 17 and 10 QTLs were identified for root and shoot traits respectively in both studies of GLM and MLM. More common QTLs with high PVEs between root and shoot traits suggested that longitudinal growth (RL and SL) played an important role in accumulation of biomass (RW and SW). Considering the obvious phenotypic differences and fewer common QTLs between
indica
and
japonica
, we suggested that there could be different mechanisms of seedling development between both subpopulations. Key pleiotropic QTLs and QTLs identified for root and shoot traits in both studies of GLM and MLM could be preferentially used in marker-assisted breeding for strong rice seedling.
Recently, neuromorphic devices have attracted great attention in the field of artificial intelligence technology at the hardware level. In particular regarding the developments of flexible ...electronics, there is an increasing interest in brain‐inspired multi‐functional perception learning system. In the present work, flexible cognitive memristors based on poly(vinyl alcohol)–graphene oxide (PVA‐GO) hybrid nanocomposite are proposed. These devices exhibit excellent electrical performance at ultralow voltage below 0.5 V with high stability against mechanical stress. The threshold voltage of resistance switching is as low as ≈0.2 V. Good endurance and stability are observed. Most importantly, the PVA‐GO‐hybrid‐based memristor demonstrates an ultralow power consumption of ≈0.5 µW during the SET process. Moreover, such cognitive memristor‐based neuron circuits demonstrate Pavlovian‐associative learning behaviors. These memristors have potential applications in ultralow‐power multi‐functional perception learning systems.
Flexible cognitive memristors are fabricated using poly(vinyl alcohol)–graphene oxide hybrid nanocomposite as the resistor switch layer. The device exhibits excellent electrical performance with resistance‐switching threshold voltage as low as ≈0.2 V. It demonstrates high stability against mechanical stress. A cognitive‐memristor‐based neuron circuit demonstrates Pavlovian associative learning behaviors. These devices have potential applications in ultralow‐power multi‐functional perception learning system.
Metal oxide semiconductor (MOSC) sensors based on nanocrystalline MoO3, In2O3, and their composites are considered to be very sensitive to detect low concentrations of ethanol, ozone, hydrogen, ...formaldehyde, and nitrogen dioxide. Here, we firstly introduced In2(MoO4)3 phase, which has excellent negative thermal expansion and high electric conductivity properties, into In2(MoO4)3@In2O3 crystalline nanocomposites. The gas-sensing performance of the In2(MoO4)3@In2O3 nanocomposites was studied upon exposure to the ethanol gas with different concentration from 5 to 300 ppm at the optimum temperature (300 °C). What's more, the device possesses ultra-high response of 110 and selectivity to ethanol. Particularly, it can effectively work in high humidity (RH = 80%) with super long-term stability of as long as 90 days, compared with the pristine In2O3 sensor and previous reports. The presented novel In2(MoO4)3@In2O3 sensor offers great opportunities for future ethanol detection under harsh conditions.
Display omitted
•In2(MoO4)3) as an outstanding functional material has not been introduced in the MOSC sensors.•The peony shaped In2(MoO4)3@In2O3 nanocomposites were fabricated via the hydrothermal and the calcination routes.•The In2(MoO4)3@2.5In2O3 sensor possesses ultra-high response of 110 under 300 ppm and good selectivity to ethanol vapor.•The device can effectively work in high humidity (RH = 80%) with super long-term stability of as long as 90 days.
Internal motions of folded proteins have been assumed to be ergodic,
i.e.
, that the dynamics of a single protein molecule averaged over a very long time resembles that of an ensemble. Here, by ...performing single-molecule fluorescence resonance energy transfer (smFRET) experiments and molecular dynamics (MD) simulations of a multi-domain globular protein, cytoplasmic protein-tyrosine phosphatase (SHP2), we demonstrate that the functional inter-domain motion is observationally non-ergodic over the time spans 10
−12
to 10
−7
s and 10
−1
to 10
2
s. The difference between observational non-ergodicity and simple non-convergence is discussed. In comparison, a single-strand DNA of similar size behaves ergodically with an energy landscape resembling a one-dimensional linear chain. The observed non-ergodicity results from the hierarchical connectivity of the high-dimensional energy landscape of the protein molecule. As the characteristic time for the protein to conduct its dephosphorylation function is ∼10 s, our findings suggest that, due to the non-ergodicity, individual, seemingly identical protein molecules can be dynamically and functionally different.
Internal motions of folded proteins have been assumed to be ergodic,
i.e.
, that the dynamics of a single protein molecule averaged over a very long time resembles that of an ensemble.
Using triphenylphosphine oxide (OPPh
3
) or tetraethyl ethylenebisphosphonate (L) as a ligand and phosphomolybdic acid hydrate as an anion template, six new lanthanide complexes Nd(OPPh
3
)
4
(H
2
O)
...3
(PMo
12
O
40
)·4CH
3
CN (
1a
), Ln(OPPh
3
)
4
(H
2
O)
3
(PMo
12
O
40
)·4C
2
H
5
OH (
2a-4a
) (Ln = Dy, Ho, Er), NdL
4
(PMo
12
O
40
)·CH
3
CN (
1b
), and ErL
3
(H
2
O)(PMo
12
O
40
)·CH
3
CN (
4b
) were synthesized. They were characterized by single crystal X-ray diffraction, elemental analysis, IR spectroscopy, powder X-ray diffraction, thermogravimetric analysis and THz spectroscopy. Also, LnL
3
(H
2
O)(PMo
12
O
40
)·CH
3
CN (
2b
,
3b
) (Ln = Dy, Ho) have been published previously and they are cited in this paper for comparison. Complexes
1a-4a
and
2b-4b
are all seven-coordination mononuclear structures centered on lanthanide ions, while complex
1b
is of eight-coordination. These mononuclear structures eventually form complicated supramolecular structures through hydrogen bonding, Mo-O π or C-H π weak interactions. The photocatalytic experiments show that the photocatalytic degradation removal rates of methylene blue are 94.93-99.55% for
1a-4a
,
1b
and
4b
, and they have good stability and can be recycled, so they can be used as catalysts to degrade dye molecules in sewage. Due to the similar structures of complexes
1a-4a
,
1b
and
4b
, they have almost the same THz absorption spectra with different absorption intensities, which may be attributed to the difference in the number of weak interactions. So THz spectroscopy can be used as a sensitive way to distinguish and determine small differences between lanthanide-organic complexes. In summary, the structures, photocatalytic properties, adsorption and terahertz spectra of a series of lanthanide complexes based on phosphine oxide ligands and Keggin type polyoxometalates were studied in this paper.
The potential relationships between the weak interactions of polyoxometalate-based lanthanide complexes and their photocatalytic properties - a new discovery from THz.
BACKGROUND AND AIMSType 2 diabetes mellitus (DM) accounts for more and more individuals worldwide. D-dimer has been demonstrated to be associated with cardiovascular diseases. The aim is to study the ...potential impact of D-dimer on the long-term prognosis of acute coronary syndrome (ACS) in the special population with type 2 DM. METHODS AND RESULTSA total of 2265 consecutive patients with DM and ACS were eligible in the study. Patients were divided into four groups according to quartiles of D-dimer concentration. Univariate and multivariate Cox regression analysis were conducted to explore the prognostic value of D-dimer for future outcomes. Patients with higher level of D-dimer presented with higher percentage of major adverse cardiovascular events (MACEs) (23.7%), all-cause death (18.3%) and cardiovascular (CV) death (9.4%) in Quartile 4. In multivariate Cox regression analysis, D-dimer was demonstrated to be independently associated with MACEs, all-cause death and CV death. The prognostic value of D-dimer is still significant in subgroups of HbA1C <7% and ≥7%. In Kaplan-Meier analysis, higher D-dimer showed poorer prognosis in MACEs, all-cause death and CV death (all log rank p < 0.001). The area under the curve (AUC) by receiver operating characteristic (ROC) curve analysis is 0.609 for MACEs, 0.708 for all-cause death, 0.747 for CV death (p < 0.001). CONCLUSIONThe present study demonstrated the independent predictive value of D-dimer for outcomes in DM patients with ACS. In addition, for the first time, we explored the prognostic value in different glucose control status.
Integrating multi-omics data is emerging as a critical approach in enhancing our understanding of complex diseases. Innovative computational methods capable of managing high-dimensional and ...heterogeneous datasets are required to unlock the full potential of such rich and diverse data.
We propose a Multi-Omics integration framework with auxiliary Classifiers-enhanced AuToencoders (MOCAT) to utilize intra- and inter-omics information comprehensively. Additionally, attention mechanisms with confidence learning are incorporated for enhanced feature representation and trustworthy prediction.
Extensive experiments were conducted on four benchmark datasets to evaluate the effectiveness of our proposed model, including BRCA, ROSMAP, LGG, and KIPAN. Our model significantly improved most evaluation measurements and consistently surpassed the state-of-the-art methods. Ablation studies showed that the auxiliary classifiers significantly boosted classification accuracy in the ROSMAP and LGG datasets. Moreover, the attention mechanisms and confidence evaluation block contributed to improvements in the predictive accuracy and generalizability of our model.
The proposed framework exhibits superior performance in disease classification and biomarker discovery, establishing itself as a robust and versatile tool for analyzing multi-layer biological data. This study highlights the significance of elaborated designed deep learning methodologies in dissecting complex disease phenotypes and improving the accuracy of disease predictions.
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