Kindergarten teachers' quality of work life (QWL) is of great significance in ensuring teacher stability, improvement in education quality, and the development of education. This study used the newly ...developed and validated tool, the QWL scale for kindergarten teachers (QWLSKT) to investigate QWL among kindergarten teachers in China. The participants comprised 936 kindergarten teachers. Psychometric results showed that the QWLSKT is a reliable and effective scale across six dimensions: health status, interpersonal relationships, working conditions, professional growth, participation in decision making, and leisure life. The Chinese teachers' evaluation of their professional growth was positive, while their evaluation of their working conditions was negative. Latent profile analysis results showed that a three-profile model had the best fitting model, comprising low, middle, and high profiles in relation to low, medium, or high scale scores, respectively. Finally, the results of hierarchical regression analysis showed that the educational level and establishment of kindergarten teachers, as well as the quality level of kindergartens and their regions, play an important role in the QWL of kindergarten teachers. The results showed that more effective policy and management strategies are needed to improve QWL among kindergarten teachers in China.
Online learning has gradually become a mainstream teaching method to replace traditional classroom teaching during the COVID-19 pandemic. However, there are some issues such as the lack of ...theoretical guidance on online learning, and the influencing factors of online learning effect are not well proven. On this basis, this study aimed to construct and test a theoretical model of online learning influencing factors among college students through a mixed-method approach in China to further explore the influencing factors of online learning and the relationship between these influencing factors. First, 130 college students were interviewed from May 2021 to November 2021, and the collected data were coded to a theoretical model through grounded theory. Second, we tested and verified the theoretical model through the analysis of survey data of 225 college students from January 2022 to July 2022. Lastly, the results indicate that the learning expectation influences the learning result through learning quality or learning interaction and their combined effects. These findings can help educators around the world gain insight into the process of online learning and improve the quality of online learning during the COVID-19 pandemic.
•Cultural Existentialism Pedagogy (CEP) is the theoretical basis of this study.•Chinese Kindergarten Teacher Quality Scale (CKTQS) helps teacher quality assessment.•Exploratory and confirmatory ...factor analyses confirmed five constructs of the CKTQS.•A survey of 1810 teachers of 81kindergartens from seven districts of Shanghai.•Shanghai kindergarten teachers show higher quality and position matters in quality.
This study develops and validates the Chinese Kindergarten Teacher Quality Scale (CKTQS) based on China’s National Professional Standards for K-12 Teachers. We randomly selected and surveyed 1834 teachers from Shanghai kindergartens. Exploratory and confirmatory factor analyses confirmed a five-factor structure (healthy condition, practical wisdom, cultural literacy, empowerment and autonomy, and loyalty and commitment), indicating satisfactory construct validity. Descriptive statistics indicated that the Shanghai kindergarten teachers were generally of good quality, ranking highly in practical wisdom. Latent profile analyses generated three profiles, (1) low teacher quality, (2) medium teacher quality, and (3) high teacher quality, while MANOVA results revealed the significant effects of age, educational background, professional title, and position on these quality levels. Finally, hierarchical regression analyses found that job position predicted better teacher quality and that public school tenure was a negative predictor, after controlling for demographic and kindergarten factors. Implications for policy-making and teacher education are discussed.
This study focuses on using the chemical compositions of plagioclase to further investigate the petrogenesis of Chang'E-5 young mare basalts and constrain its parental melt composition. Together with ...previously published data, our results show that the plagioclase in mare basalts overall displays large variations in major and trace element concentrations. Inversion of the plagioclase data indicates that the melt compositions parental to Chang'E-5 basalts have high rare earth elements (REE) concentrations similar to the high-K KREEP rocks (potassium, rare earth elements, and phosphorus). Such a signature is unlikely to result from the assimilation of KREEP components, because the estimated melt Sr shows positive correlations with other trace elements (e.g., Ba, La), which are far from the KREEP end-member. Instead, the nearly parallel REE distributions and a high degree of trace element enrichment in plagioclase indicate an extensive fractional crystallization process. Furthermore, the estimated melt REE concentrations from plagioclase are slightly higher than those from clinopyroxene, consistent with its relatively later crystallization. Using the Ti partition coefficient between plagioclase and melt, we estimated the parental melt TiO2 content from the earliest crystallized plagioclase to be ∼3.3 ± 0.4 wt%, thus providing robust evidence for a low-Ti and non-KREEP origin for the Chang'E-5 young basalts in the Procellarum KREEP terrane.
As a new type of pollutant, microplastics are of emerging widespread concern, while amount of research done in freshwater environments and organisms is litter compared to that in marine. Following ...this reality, the categories of MPs in two economic freshwater fish at 25 sites from 11 cities in the north and west rivers of Guangdong province were documented. Here, 76 individuals belong Oreochromis niloticus and Cirrhinus molitorella were investigated and microplastics were found in the GITs of 43.4% and gills of 25%. The average abundances of microplastics have significant difference between Oreochromis niloticus (0.015 items/ g) and Cirrhinus molitorella (0.031 items/g), while no difference by individual (~1.9 items). The plastics were dominated by white in color (61%), fragment in shape (67%), and lass than 1 mm in size (74%). The spatial distribution of microplastics revealed that there are significant differences between different cities in average abundances, and the highest average abundances of MPs were found in Zhanjiang city (4.25 items/individual) and Guangzhou city (0.044 items/g), respectively. Our results fully proved that the microplastics was widely ingested by wild fish species and suggested that the abundance and distribution of microplastics are positively related with the development of economy, tourism, industry, agriculture, and fishery.
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•The color, shape and size of MPs were mostly in white, fragment, and < 0.5 mm.•The abundance and spatial distribution of MPs have significant regional specificities.•The extensive of MPs in wild fish reflecting the universality of environmental MPs.
To evaluate the performance of a multi-parametric MRI (mp-MRI)-based radiomics signature for discriminating between clinically significant prostate cancer (csPCa) and insignificant PCa (ciPCa).
Two ...hundred and eighty patients with pathology-proven PCa were enrolled and were randomly divided into training and test cohorts. Eight hundred and nineteen radiomics features were extracted from mp-MRI for each patient. The minority group in the training cohort was balanced via the synthetic minority over-sampling technique (SMOTE) method. We used minimum-redundancy maximum-relevance (mRMR) selection and the LASSO algorithm for feature selection and radiomics signature building. The classification performance of the radiomics signature for csPCa and ciPCa was evaluated by receiver operating characteristic curve analysis in the training and test cohorts.
Nine features were selected for the radiomics signature building. Significant differences in the radiomics signature existed between the csPCa and ciPCa groups in both the training and test cohorts (p < 0.01 for both). The AUC, sensitivity and specificity of the radiomics signature were 0.872 (95% CI: 0.823−0.921), 0.883, and 0.753, respectively, in the training cohort, and 0.823 (95% CI: 0.669−0.976), 0.841, and 0.727, respectively, in the test cohort.
Mp-MRI-based radiomics signature have the potential to noninvasively discriminate between csPCa and ciPCa.
•Li2FeSiO4/C/Cu/Li3PO4 composites were synthesized by a sol-gel method.•Li2FeSiO4/C is modified by electronic conductor and ionic conductor.•LFS-4 exhibits enhanced rate capability and superior cycle ...performance.
The practical use of Li2FeSiO4 (LFS) is largely restricted by its inherent low electronic conductivity and slow lithium ions diffusion rate. Carbon (C) coating has been widely used to improve the electrochemical performance of LFS, but it can reduce the tap density and block lithium ion transmission. Herein, we design and synthesize the LFS/C/Cu/Li3PO4 composites with elaborate structure that the elemental Cu is encapsulated by LFS particles and Li3PO4 distributes both inside LFS particles and the surface carbon layer. The as-prepared samples with the unique structure depict enhanced electronic/ionic conductivities and kinetic properties due to the synergistic effect of Li3PO4 and Cu. LFS-4, which contains 2 wt% Cu and 2.42 wt% Li3PO4, exhibits the best rate performance with an average discharge specific capacity of 165.8, 142.9, 119.2, 102.1, 83.3 and 60.4 mAh g−1 at 1, 2, 5, 10, 20 and 40 C rate (1 C = 165.6 mA g−1). Over 800 cycles, a capacity of 116.2 mAh g−1 is maintained under the high current density of 10 C with the capacity retention of 88.9%. The study indicates that the rational design of hybrid material with multi-functional engineering possesses important significance in cathode materials for lithium-ion batteries.
To evaluate the therapeutic effect of Saccharomyces boulardii supplementation on jaundice in premature infants undergoing phototherapy.
In this article, the authors reviewed 100 hospitalized ...jaundiced premature infants under 35 weeks of gestational age. All infants were assigned to a control group (n = 45) and a treatment group (n = 55) randomly. The infants in the treatment group received S. boulardii supplementation by undergoing phototherapy and the infants in the control group were only treated by phototherapy. The total serum bilirubin levels were detected before and at the end of phototherapy, and transcutaneous bilirubin levels were measured on the 1st, 4th, 8th and 15th day of treatment. The duration of jaundice resolution and phototherapy, stool frequency, and characteristics were compared after phototherapy.
The duration of jaundice resolution and phototherapy were shortened. Total serum bilirubin level was lower than the control group at the end of phototherapy (p < 0.05). Transcutaneous bilirubin levels decreased more significantly on the 8th and 15th day of treatment (p < 0.05), while there were no significant differences on the post-treatment 1st and 4th day (p > 0.05). In addition, bowel movements including stool frequency and Bristol Stool Form Scale ratings of stools also improved after treatment.
S. boulardii in combination with phototherapy is effective and safe in reducing bilirubin levels and duration of phototherapy, accelerating jaundice resolution in premature infants with jaundice. The procedure also provided an ideal therapeutic effect of diarrhea induced by phototherapy to promote compliance and maternal-infant bonding.
The novel Bruton's tyrosine kinase inhibitor ibrutinib has demonstrated high response rates in B-cell lymphomas; however, a growing number of ibrutinib-treated patients relapse with resistance and ...fulminant progression. Using chemical proteomics and an organotypic cell-based drug screening assay, we determine the functional role of the tumour microenvironment (TME) in ibrutinib activity and acquired ibrutinib resistance. We demonstrate that MCL cells develop ibrutinib resistance through evolutionary processes driven by dynamic feedback between MCL cells and TME, leading to kinome adaptive reprogramming, bypassing the effect of ibrutinib and reciprocal activation of PI3K-AKT-mTOR and integrin-β1 signalling. Combinatorial disruption of B-cell receptor signalling and PI3K-AKT-mTOR axis leads to release of MCL cells from TME, reversal of drug resistance and enhanced anti-MCL activity in MCL patient samples and patient-derived xenograft models. This study unifies TME-mediated de novo and acquired drug resistance mechanisms and provides a novel combination therapeutic strategy against MCL and other B-cell malignancies.
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