The effects of maternal thyroid hormone levels on the course of pregnancy and birth weight have attracted interest. The aim of the present study was to consider FT3 and FT3/FT4 ratio in the ...evaluation of the effects of maternal thyroid functions in gestational transient thyrotoxicosis (GTT).
This case-control study included 45 patients with GTT and 45 healthy pregnant women. Maternal history before pregnancy, thyroid function tests, thyroid autoantibodies, and thyroid ultrasonography results in 6th to 10th weeks of pregnancy were used in the differential diagnosis of GTT. In both groups, the effects of FT3, FT4 and FT3/FT4 ratios on gestational age and birth weight were evaluated.
There was no significant difference in the gestational age between the GTT and control groups (39,3±1,0 weeks and 39,2±1,2 weeks, respectively). Birth weights were similar in both groups (3205,2±4899 g and 3196,6±309,3 g, respectively). When maternal weight was adjusted, a positive correlation was observed between maternal FT3/FT4 ratio and birth weight (r=0,317, p=0,017). Additionally there was a positive correlation between the gestational age and the birth weight in the control group (ρ=0,726, p=0,001).
GTT had no significant effect on the gestational age and the birth weight. On the other hand an increase in the maternal FT3/FT4 ratio had a positive effect on the birth weight in the patient with GTT. Maternal characteristics (age, weight, BMI) and FT3/FT4 ratio should be taken into consideration in future impact assessment studies on this issue.
Thalassemia is a common genetic disorder. We aimed to present thalassemia mutation data that covers a period of 7 years from the Mediterranean region of Turkey by comparing with hemoglobin indices ...and to contribute to prenatal diagnosis and genetic counseling studies which should be decided very quickly. In this study, in which a retrospective archive was scanned, the cases were first grouped as α and β thalassemia, and then β thalassemia mutations were examined in a total of 5 groups as UTR-Pro, Codon, IVS, β
0
, and β
+
. We have reached the family of the proband that analyzed their Hb indices and genetic mutation. All mutations were statistically compared with Hb indices, HbF, and HbA
2
. We have identified two new β thalassemia mutations that have the feature of not being defined previously HBB:C*62 A>G. (3′UTR+1536 A>G) and HBB:C*1 G>A (3′UTR+1475 G>A). The most commonly encountered 23 mutations account for 74.7% of all mutations which is unlike the literature. In the β thalassemia group, 73 different mutations were detected. The most common β thalassemia mutation was HBB: c.93-21 G>A (IVS I-110 G>A) with a frequency of 19.72%. A statistically significant difference was found when comparing the mutation groups with Hb indices. We think that it may be useful to evaluate the mutations we have newly identified too together with the Hb indices especially in evaluating the carriers of thalassemia and it will contribute to prenatal diagnosis and genetic counseling studies which should be decided very quickly.
Cutaneous leishmaniasis (CL) is a skin disease affecting all ages but especially children. Cutaneous leishmaniasis exists in Turkey, and, especially together with emigration from Syria to Turkey in ...recent years due to the civil war in Syria, the incidence of the disease has increased.
To investigate Syrian patients (SP) and Turkish patients (TP) in the pediatric age group who were diagnosed with CL and to compare the age, gender, clinical type, number of lesions, and lesion localizations of these patients.
We included CL patients aged 0-18 who were admitted to the outpatient clinic in the period 2015-2017 and in the first half of 2018. A total of 121 patients (SP,
= 87; TP,
= 34) were included in the study.
The mean ages of TP and SP were 12.06 ±4.47 and 8.68 ±5.18 years and the disease durations were 6.25 ±3.86 and 4.73 ±3.39 months respectively (
= 0.049). The total number of lesions was 247. The mean lesion number per child was 2.35 ±2.28 in SP, and 1.23 ±0.55 in TP (
= 0.002). Two and multiple lesions were significantly higher in SP (
= 0.005). It was found that the lesions were most frequently located in the head/neck (HN) region (76.9%) and 44.1% of patients with HN localization belonged to the 7-12 age group. We also found that 57.1% of the HN lesions were of the papule type in the patients.
We obtained similar results as in other studies in terms of age, gender, localization, and duration of lesions in general. When SP and TP were compared, we found that the number of lesions was higher, the disease duration was shorter, and the mean age was younger in SP.
mites are highly found in the skin of patients with rosacea. The diagnosis of
can be made by standardized skin surface biopsy. Dermoscopy is a tool used in the noninvasive diagnosis of various ...dermatological diseases.
To determine whether dermoscopic features of demodicosis are associated with the result of standardized skin surface biopsy in patients with rosacea and to compare dermoscopic features of rosacea in
-positive and negative samples and
type.
A total of 30 patients (7 male, 23 female) were included in the study. Dermoscopic examination was performed on both the clinically most severely affected areas and adjacent healthy skin. The skin surface biopsy sample was taken from the same place from where the dermoscopic image was taken.
A total of 83 (lesion n = 60, non-lesion n = 23) areas were evaluated.
was detected in 60.2% (n = 50) of the samples. Half of these samples revealed only
, and the remaining half revealed
and
Of the
-positive samples, 88% had
tails (P =0.001) and 68%
follicular openings (P = 0.002) on dermoscopy. In
+
-positive samples, the rate of scale and pustule was higher than
positive samples (P = 0.017 and P = 0032, respectively).
The sensitivity and specificity of
tail are higher than
follicular opening and scale and pustule detection with dermoscopy and may indicate the coexistence of both
and
Limited research has examined the clinical consequences of sarcopenia and myosteatosis in Crohn's disease. This study aimed to determine the prevalence, risk factors, and effects of sarcopenia and ...myosteatosis on prognostic outcomes in Crohn's disease patients who underwent magnetic resonance enterography.
This retrospective observational study included 116 Crohn's disease patients who underwent magnetic resonance enterography between January 2015 and August 2021. Skeletal muscle index was the ratio of the cross-sectional area of skeletal muscles at the L3 vertebral level to the square of the neck in cross-sectional imaging. Sarcopenia was defined as skeletal muscle index <38.5 cm2/m2 in women and <52.4 cm2/m2 in men. Myosteatosis was considered positive if the ratio of the mean signal intensity of the psoas muscle to the mean signal intensity of the cerebrospinal fluid was above 0.107.
Among the negative results in the post-procedure follow-up of the patients, a significant increase was observed in the sarcopenia group regarding abscess and the need for surgery (P < .05). Anti-tumor necrosis factor initiation was found to be significantly higher in the follow-up than in patients without myosteatosis (P = .029). In the multivariate model established with these variables, the presence of sarcopenia in the surgical follow-up was odds ratio = 5.34 (CI: 1.02-28.03, P = .047) and was found to be significantly associated with the increased risk.
The presence of myosteatosis and sarcopenia detected in magnetic resonance enterography may be a harbinger of negative outcomes in Crohn's disease patients. Nutritional support should be provided to these patients with the potential to alter the course of the disease.
INTRODUCTION: People mostly live in the nonfasting state during a normal 24-h cycle. This study aims to compare the levels of 18 biochemical parameters during different hours of the day. METHODS: A ...total of 18 biochemical tests of patients who visited outpatient clinics only once between January 1, 2010, and December 31, 2019, were evaluated at the Hatay Mustafa Kemal University (HMKU) Central Laboratory by using hospital database information. The tests are albumin (Alb), aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), alkaline phosphatase (ALP), amylase, blood urea nitrogen (BUN), calcium (Ca), total cholesterol (TC), creatine kinase (CK), creatinine (Cr), gamma-glutamyltransferase (GGT), glucose, high-density lipoprotein cholesterol (HDL-C), inorganic phosphorus (Pi), iron (Fe), total protein (TP), triglyceride (TG), and lipase. The blood samples of the patient were divided into eight groups according to their collection time as follows: (a) 07: 00-07: 59, (b) 08: 00-08: 59, (c) 09: 00-09: 59, (d) 10: 00-10: 59, (e) 11: 00-11: 59, (f ) 12: 00-13: 59, (g) 14: 00-14: 59, and (h) 15: 00-17: 00. RESULTS: A statistically significant difference was found between the groups in terms of all parameters except amylase, GGT, and TP (p<0.05). The effect size refers to the minimum amount of difference that is clinically significant. According to the effect size values, there was no significant difference between time groups in the following parameters: Alb, ALT, AST, Pi, Ca, TC, Cr, Fe, glucose, BUN, lipase, TG, ALP, HDL-C, and CK (ʈ<0.30). DISCUSSION AND CONCLUSION: When considering all of the results, nonfasting screening would not only be acceptable but also make physiologic sense.
Purpose: Despite current hypolipidemic drugs, the search for a more effective hypolipidemic agent is ongoing. In this study, it was aimed to investigate the effect of Silibinin on hyperlipidemia in ...rats fed high cholesterol diet (HCD). Materials and Methods: Rats were made obese. Rats were given egg yolk for 60 days and then 50 mg/kg, 100 mg/kg Silibinin were applied i.p. for 7 days. Results: The first and last weights of the rats were significantly different. While total cholesterol (TC), LDL, TG and VLDL levels increased significantly in the groups fed with HCD, HDL level reduced compared to control group (CG). OxLDL and TAS were significantly different between groups. Conclusion: The effects of Silibinin on serum LDL, TC, VLDL, HDL, TG, OxLDL levels and to observe the antioxidant effect, TAS and TOS were investigated in experimental obese rat models. It was concluded that Silibinin plays an effective role in lowering TG and LDL levels, increasing HDL levels and decreasing hepatic lipid accumulation in HCD rats at 100 mg/kg dose. The use of Silibinin does not cause antihyperlipidemic effect but has antioxidant effect.
Aim: Tumor microenvironment plays an important role in onset and progression of the cancer. Tumor budding (TB), tumor stroma and tumor-infiltrating lymphocytes are component of the tumor ...microenvironment. It was aim to determine the relationship of TB, tumor stroma ratio (TSR) and tumor-infiltrating lymphocytes (TILs) with clinicopathological prognostic parameters in gallbladder adenocarcinoma.
Materials and Methods: Thirty cholecystectomy cases that were diagnosed as adenocarcinoma between 2010 and 2020, that did not receive neoadjuvant therapy and of which archive slides could be accessed, were included in the study. TB, TSR and TILs were evaluated. A p<0.05 value was statistically significant.
Results: High TB score was significantly associated with higher histological grade (p=0.008), higher pT stage, lymphovascular invasion (LVI) (p=0.038), lymph node metastasis (p=0.046) and distant metastasis (p=0.036) . Patients with high TB scores had a shorter overall survival (p<0.001). In the high TILs group, lower histological grade (p=0.004), less LVI (p=0.029), fewer distant metastases (p=0.021) and lower TSR (p=0.008) were detected. Increased TCR was associated with higher histological grade (p=0.015) and increased distant metastasis (p=0.013). There was no significant effect of TCR on overall survival (p=0.239).
Conclusion: TB can be used as a novel prognostic histological characteristic in the gallbladder cancer patients. We have concluded that it is early to recommend TILs and TSR as the prognostic indicators in gallbladder cancers. In the future, further studies can be conducted on a larger number of GBC cases with a multicenter participation to clarify the prognostic value of TILs and TSR.
Amaç: Tümör mikroçevresi kanserin başlangıcında ve ilerlemesinde önemli rol oynar. Tümör tomurcuklanması (TB), tümör stroması ve tümörü infiltre eden lenfositler, tümör mikroçevresinin bileşenleridir. Bu çalışmada safra kesesi adenokarsinomunda TB, tümör stroma oranı (TSR) ve tümörü infiltre eden lenfositlerin (TILs) klinikopatolojik prognostik parametrelerle ilişkisinin belirlenmesi amaçlandı.
Gereç ve yöntem: 2010-2020 yılları arasında adenokarsinom tanısı alan, neoadjuvan tedavi almayan ve arşiv preparatlarına ulaşılabilen 30 kolesistektomi olgusu çalışmaya dahil edildi. TB, TSR ve TILs değerlendirildi. p<0.05 değeri istatistiksel olarak anlamlı kabul edildi.
Bulgular: Yüksek TB skoru, daha yüksek histolojik derece (p=0,008), daha yüksek pT evresi, lenfovasküler invazyon (LVI) (p=0,038), lenf nodu metastazı (p=0,046) ve uzak metastaz (p=0,036) ile anlamlı ilişkiliydi. TB skoru yüksek olan hastaların genel sağkalım süreleri daha kısaydı (p<0,001). Yüksek TILs grubunda, daha düşük histolojik derece (p=0,004), daha az LVI (p=0,029), daha az uzak metastaz (p=0,021) ve daha düşük TSR (p=0,008) saptandı. Yüksek TSR, daha yüksek histolojik derece (p=0.015) ve artan uzak metastaz (p=0.013) ile ilişkilendirildi. TSR'nin genel sağkalım üzerinde anlamlı bir etkisi yoktu (p=0,239).
Sonuç: TB, safra kesesi kanserli hastalarda yeni bir prognostik histolojik özellik olarak kullanılabilir. Safra kesesi kanserlerinde prognostik göstergeler olarak TILs ve TSR'yi önermek için erken olduğu kanaatindeyiz. Gelecekte, TILs ve TSR'nin prognostik değerini netleştirmek için çok merkez katılımlı daha fazla sayıda GBC vakası üzerinde çalışmalar yapılabilir.
Abstract
Background:
It is unclear, whether the initial disease severity may help to predict which COVID-19 patients at risk of developing persistent symptoms.
Aim:
The aim of this study was to ...examine whether the initial disease severity affects the risk of persistent symptoms in post-acute COVID-19 syndrome and long COVID.
Methods:
A systematic search was conducted using PUBMED, Google Scholar, EMBASE, and ProQuest databases to identify eligible articles published after January 2020 up to and including 30 August 2021. Pooled odds ratio (OR) and confidence intervals (CIs) were calculated using random effects meta-analysis.
Findings:
After searching a total of 7733 articles, 20 relevant observational studies with a total of 7840 patients were selected for meta-analysis. The pooled OR for persistent dyspnea in COVID-19 survivors with a severe versus nonsevere initial disease was 2.17 95%CI 1.62 to 2.90, and it was 1.33 95%CI 0.75 to 2.33 for persistent cough, 1.30 95%CI 1.06 to 1.58 for persistent fatigue, 1.02 95%CI 0.73 to 1.40 for persistent anosmia, 1.22 95%CI 0.69 to 2.16 for persistent chest pain, and 1.30 95%CI 0.93 to 1.81 for persistent palpitation.
Conclusions:
Contrary to expectations, we did not observe an association between the initial COVID-19 disease severity and common persistent symptoms except for dyspnea and fatigue. In addition, it was found that being in the acute or prolonged post-COVID phase did not affect the risk of symptoms. Primary care providers should be alert to potential most prevalent persistent symptoms in all COVID-19 survivors, which are not limited to patients with critical–severe initial disease.
Background and study aims:
The present study was undertaken to design a new machine learning (ML) model that can predict the presence of viremia in hepatitis C virus (HCV) antibody (anti-HCV) ...seropositive cases.
This retrospective study was conducted between January 2012-January 2022 with 812 patients who were referred for anti-HCV positivity and were examined for HCV ribonucleic acid (HCV RNA). Models were constructed with 11 features with a predictor (presence and absence of viremia) to predict HCV viremia. To build an optimal model, this current study also examined and compared the three classifier data mining approaches: RF, SVM and XGBoost.
The highest performance was achieved with XGBoost (90%), which was followed by RF (89%), SVM Linear (85%) and SVM Radial (83%) algorithms, respectively. The four most important key features contributing to the models were: alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (ALB) and anti-HCV levels, respectively, while “ALB” was replaced by the “AGE” only in the XGBoost model.
This study has shown that XGBoost and RF based ML models, incorporating anti-HCV levels and routine laboratory tests (ALT, AST, ALB), and age are capable of providing HCV viremia diagnosis with 90% and 89% accuracy, respectively. These findings highlight the potential of ML models in the early diagnosis of HCV viremia, which may be helpful in optimizing HCV elimination programs.
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