New butyrolactones aspernolides C and D, along with two known butyrolactones (A and B) were isolated from the culture of the endophytic fungus Aspergillus versicolor. Their structures were elucidated ...on the basis of extensive spectroscopic analysis, including 1D and 2D nuclear magnetic ressonance techniques, and electronic circular dichroism. The butyrolactones aspernolides C and D were tested for their anti-tobacco mosaic virus activity. The results showed that butyrolactones aspernolides C and D exhibited moderate anti-tobacco mosaic virus activity with IC50 values of 64.2 and 88.6 μM, respectively.
We present the case of a 72-year-old female patient with gallbladder cancer (GBC) who developed
recurrence and liver metastases 9 mo after irreversible electroporation ablation and oral tegafur (a ...fluoropyrimidine derivative) chemotherapy, which failed to control the progression of the disease. The patient further developed metastases in the lymph nodes around the head of the pancreas. The patient had severe anemia, requiring weekly blood transfusions. The gallbladder tumor invaded the descending part of the duodenum, causing intestinal leakage and hepatic colonic adhesion.
The patient refused other treatments and began daily hydrogen inhalation therapy. After 1 mo of treatment, the gallbladder and liver tumors continued to progress, and intestinal obstruction occurred. After continuous hydrogen therapy and symptomatic treatments including gastrointestinal decompression and intravenous nutrition support, the intestinal obstruction was gradually relieved. Three months after hydrogen therapy, the metastases in the abdominal cavity gradually reduced in size, her anemia and hypoalbuminemia were corrected, lymphocyte and tumor marker levels returned to normal, and the patient was able to resume normal life.
This is the first report of an efficacy and safety study about hydrogen therapy in patient with metastatic GBC and a critical general condition, who has remained stable for more than 4 months.
New Biphenyls from Garcinia multiflora Gao, Xue-Mei; Ji, Bing-Kun; Li, Yin-Ke ...
Journal of the Brazilian Chemical Society,
01/2016, Volume:
27, Issue:
1
Journal Article
Peer reviewed
Open access
Three new biphenyls were isolated from Garcinia multiflora. The structures of these biphenyls were elucidated by spectroscopic methods, and their rotavirus activity was evaluated.
Two new biphenyls (1 and 2) and three known xanthones (3-5) were isolated from the ethanol extract of the stems of Garcinia tetralata. Structural elucidations of 1-2 were elucidated by spectroscopic ...methods including extensive 1D- and 2D-nuclear magnetic resonance spectroscopy techniques. Compounds 1-2 showed anti-rotavirus activities with SI above 10.
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•The metallogenic link among Au, Sb and Hg has been identified.•Sulfur in the Au-Sb-Hg-rich fluids derived from the Cambrian ore-bearing strata via thermal-chemical sulfate reduction ...process.•Fluid-rock interaction and changes of temperature and oxygen-sulfur fugacity are responsible for Au and Sb mineralization, respectively.•The Au-Sb-Hg deposits are best classified as orogenic type.
The turbidite-hosted Au-Sb-Hg deposits in the Sandu-Danzhai area are distributed along the southwestern marginal fault of the Jiangnan Orogen, yet any genetic link among the Au, Sb and Hg mineralization and their respective ore-forming process remain unclear. Here, we investigate the Paiting Au(-Hg) and Miaolong Au-Sb deposits and present a new metallogenic model based on detailed petrographic observations, and in-situ trace element (EPMA and LA-ICP-MS) and sulfur isotope (fs-LA-MC-ICPMS) analyses on sulfide minerals. Our results show that the ore formation in the Sandu-Danzhai metallogenic belt (SDMB) can be divided into Au (pyrite + arsenopyrite + dolomite), Au-Sb (pyrite + arsenopyrite + stibnite + quartz), Sb (stibnite + native antimony + barite + dolomite + quartz) and Hg (cinnabar + calcite) stages, based on mineral paragenetic and vein crosscutting relationships. Trace element compositions suggest that progressive As enrichment in pyrite is accompanied by increasing Au, Sb and Cu contents, implying that these elements may have been leached from the same source via fluid-rock reactions. Sulfur isotope compositions of the sulfates and sulfides in the Au-Sb-Hg ores reveal that the sulfur was originated from thermal-chemical sulfate reduction (TSR) of marine sulfates in the Cambrian ore-bearing strata. Thus, we propose that deep metamorphic fluids (as evidenced from the high fluid CO2 and CH4 contents) may have promoted ore-material (e.g., Au, Sb, As, Hg) mobilization in the metamorphic basement and/or Cambrian strata. As for the metal transport and precipitation mechanism, fluid-rock interaction may have decreased the ore-fluid As content and caused auriferous pyrite precipitation. Meanwhile, changes in temperature and oxygen-sulfur fugacity may have significantly decreased Sb solubility, leading to extensive stibnite precipitation. Cinnabar associated with calcite was likely deposited via carbonate dissolution in the Cambrian strata in late hydrothermal (waning) stage. Overall, we propose that the Au-Sb-Hg deposits in the SDMB are best classified as orogenic type, and the metallogeny was controlled by boundary faults of the Jiangnan Orogen.
It is an important way to massively rear parasitoid wasps by using appropriate methods to treat the wasps' hosts and preserve them for a long duration. Pachycrepoideus vindemmiae Rondani is a pupal ...parasitoid of several dipteral pests, being of significance for the biological control of the pests. In this paper, housefly pupae were frozen at -20 degrees C, cold storage-preserved at 6 degrees C, and CO2-asphyxiated for 1-, 3-, and 30 days, respectively, and some pupae were heat-killed and cold storage-preserved for 30 days, aimed to approach the effects of these treatment methods on the reproduction of P. vindemmiae on the pupae. The results showed that P. vindemmiae could reproduce on the pupae treated with the above-mentioned methods, and the tibia length of the offspring had less difference with that on the fresh pupae. However, the reproduction of P. vindemmiae on the pupae treated with the above-mentioned methods except frozen decreased with the increasing preserving duration of the pupae. At the prerequi
With the ongoing construction and development of the enhanced long-range navigation (eLoran) system, people's needs for the accuracy of positioning navigation and timing (PNT) service provided by the ...Loran system are increasing. Due to the high altitude at which the new eLoran transmit station will be constructed, the effects of elevation cannot be discounted. Since the existing Loran propagation model has not systematically taken the impact of elevation into account, new factors have to be added to existing model for users at high-altitude areas. In this letter, the groundwave transmission delay model's height correction factor is provided. Also, by using a modified ellipsoid expansion technique, it is possible to investigate the impact of elevation on the calculation of geodetic line length, a crucial step in the PNT solution of the Loran system. The findings indicate that, in comparison to the built-in algorithm of the current receiver, taking elevation into consideration will result in unavoidable correction for users who are 250 km or less from the transmitter or for users who are more than 500 km away.
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•Large-area MS2 vertical nanosheets with mixed 1T/2H phases are fabricated.•The MS2 nanosheets show a low detection limit and a good linear response.•The substrates provide excellent ...uniformity, reproducibility and long-term stability.•Abundant edge-active sites enable sufficient molecule-substrate interaction.
Two-dimensional (2D) materials have recently attracted abundant interest as cost-effective surface-enhanced Raman scattering (SERS) substrates for precise molecular monitoring. However, the challenge of large-area substrate production with high stability and uniformity still imposes unavoidable barrier of 2D materials for practical applications. In this work, we show that large-scale MS2 (M = Mo, W) vertical nanosheets with mixed 1T/2H phases on metal foils as SERS substrates can be fabricated by a simple and low-cost route. We find that the detection limits of MoS2 and WS2 can be up to 5 × 10–8 M for Rhodamine 6G (R6G), which are much lower than those of most semiconductor SERS substrates. Moreover, the recyclable and scalable substrates provide excellent uniformity and reproducibility on the whole substrates (3 × 4 cm2), and the Raman signals keep unchanged after 30 days. The excellent SERS performance is contributed by the high content of 1T phase and 1T-2H heterostructures that significantly improve the charge transfer process, and rich edges that enable sufficient interaction with the interested molecules. Our findings offer potential candidates for practical applications in the food security field and provide insight to design novel SERS substrates.
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