On a global scale demand for the products of the extractive industries is ever increasing. Extraction of the targeted resource results in the concurrent production of a significant volume of waste ...material, including tailings, which are mixtures of crushed rock and processing fluids from mills, washeries or concentrators that remain after the extraction of economic metals, minerals, mineral fuels or coal. The volume of tailings is normally far in excess of the liberated resource, and the tailings often contain potentially hazardous contaminants. A priority for a reasonable and responsible mining organization must be to proactively isolate the tailings so as to forestall them from entering groundwaters, rivers, lakes and the wind. There is ample evidence that, should such tailings enter these environments they may contaminate food chains and drinking water. Furthermore, the tailings undergo physical and chemical change after they have been deposited. The chemical changes are most often a function of exposure to atmospheric oxidation and tends to make previously, perhaps safely held contaminants mobile and available. If the tailings are stored under water, contact with the atmosphere is substantially reduced, thereby forestalling oxygen-mediated chemical change. It is therefore accepted practice for tailings to be stored in isolated impoundments under water and behind dams. However, these dams frequently fail, releasing enormous quantities of tailings into river catchments. These accidents pose a serious threat to animal and human health and are of concern for extractive industries and the wider community. It is therefore of importance to understand the nature of the material held within these dams, what best safety practice is for these structures and, should the worst happen, what adverse effects such accidents might have on the wider environment and how these might be mitigated. This paper reviews these factors, covering the characteristics, types and magnitudes, environmental impacts, and remediation of mine tailings dam failures.
Graphene is a true wonder material that promises much in a variety of applications that include electronic devices, supercapacitors, batteries, composites, flexible transparent displays and sensors. ...This review highlights the different methods available for the synthesis of graphene and discusses the viability and practicalities of using the materials produced
via
these methods for different graphene-based applications.
This review details the synthesis of graphene and discusses the practicalities of using the different materials produced for graphene applications.
The genetic basis of disease has largely focused on coding regions. However, it has become clear that a large proportion of the noncoding genome is functional and harbors genetic variants that ...contribute to disease etiology. Here, we review recent examples of inherited noncoding alterations that are responsible for Mendelian disorders or act to influence complex traits. We explore both rare and common genetic variants and discuss the wide range of mechanisms by which they affect gene regulation to promote disease. We also debate the challenges and progress associated with identifying and interpreting the functional and clinical significance of genetic variation in the context of the noncoding regulatory landscape.
A large proportion of the noncoding genome is functional and can harbor genetic variants that are causally related to Mendelian disorders or act to influence complex traits.Noncoding variants can influence gene expression or function through diverse functional units including untranslated regions, DNA regulatory elements, and noncoding RNAs.The current challenges for the interpretation of noncoding genetic variants include identifying the disease-relevant cell type, predicting and evaluating the underlying mechanisms, and the lack of appropriate in vivo models.A comprehensive understanding of the mechanisms and impact of noncoding genetic variation in human disease will assist future genetic diagnoses and selective targeting as a therapeutic strategy.
When two people look at the same object in the environment and are aware of each other’s attentional state, they find themselves in a shared-attention episode. This can occur through intentional or ...incidental signaling and, in either case, causes an exchange of information between the two parties about the environment and each other’s mental states. In this article, we give an overview of what is known about the building blocks of shared attention (gaze perception and joint attention) and focus on bringing to bear new findings on the initiation of shared attention that complement knowledge about gaze following and incorporate new insights from research into the sense of agency. We also present a neurocognitive model, incorporating first-, second-, and third-order social cognitive processes (the shared-attention system, or SAS), building on previous models and approaches. The SAS model aims to encompass perceptual, cognitive, and affective processes that contribute to and follow on from the establishment of shared attention. These processes include fundamental components of social cognition such as reward, affective evaluation, agency, empathy, and theory of mind.
Personal data is ubiquitous in the digital world, can be highly valuable in aggregate, and can lead to unintended intrusions for the data creator. However, individuals’ expressions of concern about ...exposure of their personal information are generally not matched by their behavioural caution. One reason for this mismatch could be the varied and intangible value of personal data. We present three studies investigating the potential association between personal data value and privacy behaviour, assessing both individual and cross-cultural differences in personal data valuation, comparing collectivist and individualistic cultures. Study 1a, using a representative UK sample, found no relationship between personal data value and privacy behaviour. However, Study 1b found Indian (collectivist) participants’ privacy behaviour was sensitive to personal data value, unlike US (individualist) participants. Study 2 showed that in a UK sample, privacy behaviour was sensitive to personal data value but only for individuals who think of themselves as more similar to others (i.e., self-construe as similar, rather than different). We suggest those who prioritise group memberships are more sensitive to unintentional disclosure harm and therefore behave in accordance with personal data valuations—which informs the privacy concern-behaviour relationship. Our findings can suggest approaches to encourage privacy behaviours.
This review examines mechanisms contributing to the intergenerational transmission of self-regulation. To provide an integrated account of how self-regulation is transmitted across generations, we ...draw from over 75 years of accumulated evidence, spanning case studies to experimental approaches, in literatures covering developmental, social, and clinical psychology, and criminology, physiology, genetics, and human and animal neuroscience (among others). First, we present a taxonomy of what self-regulation is and then examine how it develops-overviews that guide the main foci of the review. Next, studies supporting an association between parent and child self-regulation are reviewed. Subsequently, literature that considers potential social mechanisms of transmission, specifically parenting behavior, interparental (i.e., marital) relationship behaviors, and broader rearing influences (e.g., household chaos) is considered. Finally, evidence that prenatal programming may be the starting point of the intergenerational transmission of self-regulation is covered, along with key findings from the behavioral and molecular genetics literatures. To integrate these literatures, we introduce the self-regulation intergenerational transmission model, a framework that brings together prenatal, social/contextual, and neurobiological mechanisms (spanning endocrine, neural, and genetic levels, including gene-environment interplay and epigenetic processes) to explain the intergenerational transmission of self-regulation. This model also incorporates potential transactional processes between generations (e.g., children's self-regulation and parent-child interaction dynamics that may affect parents' self-regulation) that further influence intergenerational processes. In pointing the way forward, we note key future directions and ways to address limitations in existing work throughout the review and in closing. We also conclude by noting several implications for intervention work.
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CEKLJ, FFLJ, NUK, ODKLJ, PEFLJ
•This paper presents an assessment of the key challenges of COVID-19 through an IS and IM lens.•The pandemic has forced governments and decision makers to reassess the use of IS and technology.•AI ...could engender better, more informed decision making during crisis management scenarios.•Privacy and security are key underlying concerns for many citizens during the pandemic.•In developing countries, the digital divide is most apparent due to social and cultural barriers.
The COVID-19 pandemic has forced many organisations to undergo significant transformation, rethinking key elements of their business processes and use of technology to maintain operations whilst adhering to a changing landscape of guidelines and new procedures. This study offers a collective insight to many of the key issues and underlying complexities affecting organisations and society from COVID-19, through an information systems and technological perspective. The views of 12 invited subject experts are collated and analysed where each articulate their individual perspectives relating to: online learning, digital strategy, artificial intelligence, information management, social interaction, cyber security, big data, blockchain, privacy, mobile technology and strategy through the lens of the current crisis and impact on these specific areas. The expert perspectives offer timely insight to the range of topics, identifying key issues and recommendations for theory and practice.
Newborn piglets have a high incidence of preweaning mortality that is not only associated with low birth weights but also with the presence of intra-uterine growth-restricted (IUGR) piglets. Such ...IUGR piglets are commonly seen in litters from hyperprolific sows as a result of insufficient placental transfer of nutrients. Nutritional strategies can be used prior to and during gestation to enhance foetal development and can also be implemented in the transition period to reduce the duration of farrowing and increase colostrum yield. Recent findings showed that the energy status of sows at the onset of farrowing is crucial to diminish stillbirth rate. Newborn piglets often fail to consume enough colostrum to promote thermostability and subsequent growth, and this is particularly problematic in very large litters when there are fewer available teats than the number of suckling piglets. One injection of 75 IU of oxytocin approximately 14 h after farrowing can prolong the colostral phase, hence increasing the supply of immunoglobulins to piglets. Nevertheless, assistance must be provided to piglets after birth in order to increase their chance of survival. Various approaches can be used, such as: (1) optimising the farrowing environment, (2) supervising farrowing and assisting newborn piglets, (3) using cross-fostering techniques, (4) providing nurse sows, and 5) providing artificial milk. Although research advances have been made in developing feeding and management strategies for sows that increase performance of their newborn piglets, much work still remains to be done to ensure that maximal outcomes are achieved.
SARS-CoV-2 has a zoonotic origin and was transmitted to humans via an undetermined intermediate host, leading to infections in humans and other mammals. To enter host cells, the viral spike protein ...(S-protein) binds to its receptor, ACE2, and is then processed by TMPRSS2. Whilst receptor binding contributes to the viral host range, S-protein:ACE2 complexes from other animals have not been investigated widely. To predict infection risks, we modelled S-protein:ACE2 complexes from 215 vertebrate species, calculated changes in the energy of the complex caused by mutations in each species, relative to human ACE2, and correlated these changes with COVID-19 infection data. We also analysed structural interactions to better understand the key residues contributing to affinity. We predict that mutations are more detrimental in ACE2 than TMPRSS2. Finally, we demonstrate phylogenetically that human SARS-CoV-2 strains have been isolated in animals. Our results suggest that SARS-CoV-2 can infect a broad range of mammals, but few fish, birds or reptiles. Susceptible animals could serve as reservoirs of the virus, necessitating careful ongoing animal management and surveillance.
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