Giano is a Cryogenic Spectrograph located in T.N.G. (Spain) and commisioned in 2013. It works in the range 950-2500 nm with a resolving power of 50000. This instrument was designed and built for ...direct feeding from the telescope 2. However, due to constraints imposed on the telescope interfacing during the pre-commissioning phase, it had to be positioned on the rotating building, far from the telescope focus. Therefore, a new interface to the telescope, based on IR-transmitting ZBLAN fibers with 85\mu m core, was developed.Originally designed to work directly at the \(f/11\) nasmyth focus of the telescope, in 2011 it has decided to use a fiber to feed it. The beam from the telescope is focused on a double fiber boundle by a Preslit Optical Bench attached to the Nasmith A interface of the telescope. This Optical Bench contains the fiber feeding system and other important features as a guiding system, a fiber viewer, a fiber feed calibration lamp and a nodding facility between the two fibers. The use of two fibers allow us to have in the echellogram two spectrograms side by side in the same acquisition: one of the star and the other of the sky or simultaneously to have the star and a calibration lamp. Before entering the cryostat the light from the fiber is collectd by a second Preslit Optical Bench attached directly to the Giano cryostat: on this bench the correct f-number to illuminate the cold stop is generated and on the same bench is placed an image slicer to increase the efficiency of the system.
Aims Determining the intensity of lines and continuum airglow emission in the H-band is important for the design of faint-object infrared spectrographs. Existing spectra at low/medium resolution ...cannot disentangle the true sky-continuum from instrumental effects (e.g. diffuse light in the wings of strong lines). We aim to obtain, for the first time, a high resolution infrared spectrum deep enough to set significant constraints on the continuum emission between the lines in the H-band. Methods During the second commissioning run of the GIANO high-resolution infrared spectrograph at La Palma Observatory, we pointed the instrument directly to the sky and obtained a deep spectrum that extends from 0.97 to 2.4 micron. Results The spectrum shows about 1500 emission lines, a factor of two more than in previous works. Of these, 80% are identified as OH transitions; half of these are from highly excited molecules (hot-OH component) that are not included in the OH airglow emission models normally used for astronomical applications. The other lines are attributable to O2 or unidentified. Several of the faint lines are in spectral regions that were previously believed to be free of line emission. The continuum in the H-band is marginally detected at a level of about 300 photons/m^2/s/arcsec^2/micron, equivalent to 20.1 AB-mag/arcsec^2. The observed spectrum and the list of observed sky-lines are published in electronic format. Conclusions Our measurements indicate that the sky continuum in the H-band could be even darker than previously believed. However, the myriad of airglow emission lines severely limits the spectral ranges where very low background can be effectively achieved with low/medium resolution spectrographs. We identify a few spectral bands that could still remain quite dark at the resolving power foreseen for VLT-MOONS (R ~6,600).
The inner disk of the Galaxy has a number of young star clusters dominated by red supergiants that are heavily obscured by dust extinction and observable only at infrared wavelengths. These clusters ...are important tracers of the recent star formation and chemical enrichment history in the inner Galaxy. During the technical commissioning and as a first science verification of the GIANO spectrograph at the Telescopio Nazionale Galileo, we secured high-resolution (R~50,000) near-infrared spectra of three red supergiants in the young Scutum cluster RSGC2. Taking advantage of the full YJHK spectral coverage of GIANO in a single exposure, we were able to identify several tens of atomic and molecular lines suitable for chemical abundance determinations. By means of spectral synthesis and line equivalent width measurements, we obtained abundances of Fe and other iron-peak elements such as V, Cr, Ni, of alpha (O, Mg, Si, Ca and Ti) and other light elements (C, N, Na, Al, K, Sc), and of some s-process elements (Y, Sr). We found iron abundances between half and one third solar and solar-scaled X/Fe abundance patterns of iron-peak, alpha and most of the light elements, consistent with a thin-disk chemistry. We found a depletion of C/Fe and enhancement of N/Fe, consistent with CN burning, and low 12C/13C abundance ratios (between 9 and 11), requiring extra-mixing processes in the stellar interiors during the post-main sequence evolution. Finally, we found a slight Sr/Fe enhancement and a slight Y/Fe depletion (by a factor of <=2), with respect to solar.
A flux-calibrated high resolution spectrum of the airglow emission is a practical lambda-calibration reference for astronomical spectral observations. It is also useful for constraining the molecular ...parameters of the OH molecule and the physical conditions in the upper mesosphere. methods: We use the data collected during the first technical commissioning of the GIANO spectrograph at the Telescopio Nazionale Galileo (TNG). The high resolution (R~50,000) spectrum simultaneously covers the 0.95-2.4 micron wavelength range. Relative flux calibration is achieved by the simultaneous observation of spectrophotometric standard star. results: We derive a list of improved positions and intensities of OH infrared lines. The list includes Lambda-split doublets many of which are spectrally resolved. Compared to previous works, the new results correct errors in the wavelengths of the Q-branch transitions. The relative fluxes of OH lines from different vibrational bands show remarkable deviations from theoretical predictions: the Deltav=3,4 lines are a factor of 2 and 4 brighter than expected. We also find evidence of a significant fraction (1-4%) of OH molecules with ``non-thermal'' population of high-J levels. Finally we list wavelengths and fluxes of 153 lines not attributable to OH. Most of these can be associated to O2, while 37 lines in the H band are not identified. The O2 and unidentified lines in the H band account for ~5% of the total airglow flux in this band.
•Empirical relations between ISW and initial experimental setting parameters.•The ISW shoaling process affects the consequent breaking mechanism.•Breaking ISW features nonlinearly related with the ...increase of pycnocline thickness.
Internal solitary waves (ISWs) propagating in a two layer stratified fluid system are studied by laboratory experiments through the standard lock-release method. We investigated the generation, propagation, and breaking phases of large amplitude internal solitary waves of depression, propagating horizontally in a wave tank. ISWs main features depend on the geometrical parameters that define the initial experimental setting. Relations between ISWs geometric and kinematic features and the initial setting parameters are analyzed and empirical relations are developed. The approach of the ISWs towards a uniform slope is investigated. Depending on both wave properties and slopes values, different physical processes characterize the shoaling phase, causing different breaker type. Following a qualitatively analysis of the different breaking mechanisms, collapsing-plunging breakers show the larger contribution in terms of mixing. The characteristics of the breaking events affecting internal wave packets propagating towards the North of the Messina Strait (Mediterranean Sea) are discussed. Additional laboratory experiments are performed to investigate how the pycnocline thickness is affected by the breaking of plunging ISWs. The consequent increase of the pycnocline thickness results to be nonlinearly related with the Iribarren number.
GIANO is an IR cross-dispersed echelle spectrometer designed to achieve high throughput, high resolving power, wide band coverage and high accuracy radial velocity measurements. It also includes ...polarimetric capabilities and a low resolution mode that make it a very versatile, common user instrument which will be permanently mounted and available at one of the Nasmyth foci of the Telescopio Nazionale Galileo (TNG) located at Roque de Los Muchachos Observatory (ORM), La Palma, Spain. This project was selected by INAF as the top priority instrument among those proposed within the Second Generation Instrumentation Plan of the TNG. More information on this project can be found at the web page http://www.bo.astro.it/giano.
Abstract Background Head and neck (H&N) cancers are a heterogeneous group of malignancies, affecting various sites, with different prognoses. The aims of this study are to analyse survival for ...patients with H&N cancers in relation to tumour location, to assess the change in survival between European countries, and to investigate whether survival improved over time. Methods We analysed about 250,000 H&N cancer cases from 86 cancer registries (CRs). Relative survival (RS) was estimated by sex, age, country and stage. We described survival time trends over 1999–2007, using the period approach. Model based survival estimates of relative excess risks (RERs) of death were also provided by country, after adjusting for sex, age and sub-site. Results Five-year RS was the poorest for hypopharynx (25%) and the highest for larynx (59%). Outcome was significantly better in female than in male patients. In Europe, age-standardised 5-year survival remained stable from 1999–2001 to 2005–2007 for laryngeal cancer, while it increased for all the other H&N cancers. Five-year age-standardised RS was low in Eastern countries, 47% for larynx and 28% for all the other H&N cancers combined, and high in Ireland and the United Kingdom (UK), and Northern Europe (62% and 46%). Adjustment for sub-site narrowed the difference between countries. Fifty-four percent of patients was diagnosed at advanced stage (regional or metastatic). Five-year RS for localised cases ranged between 42% (hypopharynx) and 74% (larynx). Conclusions This study shows survival progresses during the study period. However, slightly more than half of patients were diagnosed with regional or metastatic disease at diagnosis. Early diagnosis and timely start of treatment are crucial to reduce the European gap to further improve H&N cancers outcome.
ObjectivesTo analyse the prevalence of CECR1 mutations in patients diagnosed with early onset livedo reticularis and/or haemorrhagic/ischaemic strokes in the context of inflammation or polyarteritis ...nodosa (PAN). Forty-eight patients from 43 families were included in the study.MethodsDirect sequencing of CECR1 was performed by Sanger analysis. Adenosine deaminase 2 (ADA2) enzymatic activity was analysed in monocyte isolated from patients and healthy controls incubated with adenosine and with or without an ADA1 inhibitor.ResultsBiallelic homozygous or compound heterozygous CECR1 mutations were detected in 15/48 patients. A heterozygous disease-associated mutation (p.G47V) was observed in two affected brothers. The mean age of onset of the genetically positive patients was 24 months (6 months to 7 years). Ten patients displayed one or more cerebral strokes during their disease course. Low immunoglobulin levels were detected in six patients. Thalidomide and anti-TNF (tumour necrosis factor) blockers were the most effective drugs. Patients without CECR1 mutations had a later age at disease onset, a lower prevalence of neurological and skin manifestations; one of these patients displayed all the clinical features of adenosine deaminase 2deficiency (DADA2) and a defective enzymatic activity suggesting the presence of a missed mutation or a synthesis defect.ConclusionsDADA2 accounts for paediatric patients diagnosed with PAN-like disease and strokes and might explain an unrecognised condition in patients followed by adult rheumatologist. Timely diagnosis and treatment with anti-TNF agents are crucial for the prevention of severe complications of the disease. Functional assay to measure ADA2 activity should complement genetic testing in patients with non-confirming genotypes.
Rituximab (RTX) efficacy in NMO is suggested by several case series. No consensus exists on optimal dosing strategies. At present the treatment schedules more frequently used are 375 mg/m2/week iv ...for 4 weeks (RTX-A) and 1000 mg iv twice, 2 weeks apart (RTX-B). Aim of this study is to confirm RTX efficacy and safety in the treatment of NMO and to evaluate whether a most favourable dosage regimen exists. Data on RTX-treated NMO patients were collected from 13 Italian Hospitals. 73 patients (64 F), were enlisted. RTX-A was administered in 42/73 patients, RTX-B in 31/73. Median follow-up was 27 months (range 7–106). Mean relapse rate in the previous year before RTX start was 2.2 ± 1.3 for RTX-A and 2.3 ± 1.2 for RTX-B. ARR in the first year of treatment was 0.8 ± 0.9 for RTX-A and 0.2 ± 0.4 for RTX-B, in the second year of treatment was 0.9 ± 1.5 for RTX-A and 0.4 ± 0.8 for RTX-B patients (
p
= 0.001 for the first year, ns (0.09) for the second year). RTX-B was more effective in delaying the occurrence of a relapse (HR 2.2 (95 % IC 1.08–4.53)
p
= 0.02). Adverse events were described in 19/73 patients (mainly urinary tract and respiratory infections, and infusion reactions). Two deaths were reported in severely disabled patients. Though with the limitations of an observational study, our data support RTX efficacy in NMO and suggest that high dose pulses might be more effective than a more fractioned dose.
Subaqueous, asymmetric sand waves are typically observed in marine channel/canyon systems, tidal environments, and continental slopes exposed to strong currents, where they are formed by current ...shear resulting from a dominant unidirectional flow. However, sand-wave fields may be readily observed in marine environments where no such current exists; the physical processes driving their formation are enigmatic or not well understood. We propose that internal solitary waves (ISWs) induced by tides can produce an effective, unidirectional boundary "current" that forms asymmetric sand waves. We test this idea by examining a sand-wave field off the Messina Strait, where we hypothesize that ISWs formed at the interface between intermediate and surface waters are refracted by topography. Hence, we argue that the deflected pattern (i.e., the depth-dependent orientation) of the sand-wave field is due to refraction of such ISWs. Combining field observations and numerical modelling, we show that ISWs can account for three key features: ISWs produce fluid velocities capable of mobilizing bottom sediments; the predicted refraction pattern resulting from the interaction of ISWs with bottom topography matches the observed deflection of the sand waves; and predicted migration rates of sand waves match empirical estimates. This work shows how ISWs may contribute to sculpting the structure of continental margins and it represents a promising link between the geological and oceanographic communities.
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