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  • CRISPR-DAV: CRISPR NGS data... CRISPR-DAV: CRISPR NGS data analysis and visualization pipeline
    Wang, Xuning; Tilford, Charles; Neuhaus, Isaac ... Bioinformatics, 12/2017, Volume: 33, Issue: 23
    Journal Article
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    Open access

    The simplicity and precision of CRISPR/Cas9 system has brought in a new era of gene editing. Screening for desired clones with CRISPR-mediated genomic edits in a large number of samples is made ...
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2.
  • 'Cold shock' increases the ... 'Cold shock' increases the frequency of homology directed repair gene editing in induced pluripotent stem cells
    Guo, Q; Mintier, G; Ma-Edmonds, M ... Scientific reports, 02/2018, Volume: 8, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Using CRISPR/Cas9 delivered as a RNA modality in conjunction with a lipid specifically formulated for large RNA molecules, we demonstrate that homology directed repair (HDR) rates between 20-40% can ...
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  • The Hemochromatosis Gene Pr... The Hemochromatosis Gene Product Complexes with the Transferrin Receptor and Lowers Its Affinity for Ligand Binding
    Feder, John N.; Penny, David M.; Irrinki, Alivelu ... Proceedings of the National Academy of Sciences - PNAS, 02/1998, Volume: 95, Issue: 4
    Journal Article
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    We recently reported the positional cloning of a candidate gene for hereditary hemochromatosis called HFE. The gene product, a member of the major histocompatibility complex class I-like family, was ...
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  • Quantitative PCR tissue exp... Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members
    Chen, Jian; Williams, Sandy; Ho, Samantha ... Diabetes Therapy, 12/2010, Volume: 1, Issue: 2
    Journal Article
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    SGLT2 (for “Sodium GLucose coTransporter” protein 2) is the major protein responsible for glucose reabsorption in the kidney and its inhibition has been the focus of drug discovery efforts to treat ...
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5.
  • Expression and Characteriza... Expression and Characterization of Human Transient Receptor Potential Melastatin 3 (hTRPM3)
    Lee, Ning; Chen, Jian; Sun, Lucy ... Journal of biological chemistry/˜The œJournal of biological chemistry, 06/2003, Volume: 278, Issue: 23
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    Transient receptor potential (TRP) cation-selective channels are an emerging class of proteins that are involved in a variety of important biological functions including pain transduction, ...
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  • An Analytical Comparison of... An Analytical Comparison of Dako 28-8 PharmDx Assay and an E1L3N Laboratory-Developed Test in the Immunohistochemical Detection of Programmed Death-Ligand 1
    Cogswell, John; Inzunza, H. David; Wu, Qiuyan ... Molecular diagnosis & therapy, 02/2017, Volume: 21, Issue: 1
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    Aim Nivolumab, a fully human immunoglobulin G4 programmed death-1 (PD-1) immune checkpoint inhibitor antibody, has activity in melanoma, non–small-cell lung cancer (NSCLC), renal cell carcinoma ...
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  • Identification and validati... Identification and validation of G protein-coupled receptors modulating flow-dependent signaling pathways in vascular endothelial cells
    Qiu, Dike; Xu, Ke; Chung, Namjin ... Frontiers in molecular biosciences, 06/2023, Volume: 10
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    Vascular endothelial cells are exposed to mechanical forces due to their presence at the interface between the vessel wall and flowing blood. The patterns of these mechanical forces (laminar vs. ...
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  • Identification of Acyl Coen... Identification of Acyl Coenzyme A:Monoacylglycerol Acyltransferase 3, an Intestinal Specific Enzyme Implicated in Dietary Fat Absorption
    Cheng, Dong; Nelson, Thomas C.; Chen, Jian ... Journal of biological chemistry/˜The œJournal of biological chemistry, 04/2003, Volume: 278, Issue: 16
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    Acyl coenzyme A:monoacylglycerol acyltransferase (MGAT) catalyzes the synthesis of diacylglycerol using 2-monoacylglycerol and fatty acyl coenzyme A. This enzymatic reaction is believed to be an ...
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  • Asymmetric Localization of ... Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis
    Zhong, Weimin; Feder, John N; Jiang, Ming-Ming ... Neuron, 07/1996, Volume: 17, Issue: 1
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    During Drosophila neurogenesis, differential segregation of Numb is necessary for daughter cells of asymmetric divisions to adopt distinct fates, at least partly by biasing the Notch-mediated ...
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  • The cloning of the gene for... The cloning of the gene for hereditary hemochromatosis
    Feder, John N; Thomas, Winston Clinical chemistry 58, Issue: 10
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    Because individual phased chromosomes were analyzed, we could accurately recreate the haplotype of the ancestral chromosome. The gene must reside between 2 markers known as D6S2238 and D6S2241, a ...
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