Recycling of iron and steelmaking dusts is a key issue in environmental protection efforts and to ensure efficient utilization. In this investigation, we developed a novel recovery process that uses ...a dispersed in-situ phase induced by an explosive reaction of composite balls of iron and steelmaking dusts. We designed and prepared composite balls for this function using a laboratory model batch-type balling disc(at 12 r/min) and optimized the feeding modes in 180-t and 260-t basic oxygen furnace(BOF) converters. The results indicate that feeding composite balls into BOF converters is an effective novel technology for recovering iron and steelmaking dusts. The period after hot metal charging and prior to the oxygen-blowing process is the most reasonable time to feed composite balls. Composite ball treatment is not appropriate for steel production with sulfur requirements lower than 80 ppm. The maximum composite ball feeding amount is 40 kg/t and the iron yield rate is better than 95%. Compared with the conventional recycling process of sludge and dust, this novel technology is more convenient and efficient, saving up to 309 RMB per ton of steel. Further investigation of this novel recycling technology is merited.
Aim： A novel coumarin derivative 7-hydroxy-5-methoxy-4-methyl-3-（4-methylpiperazin-l-yl）-coumarin （IMM-HO04） has shown antiapoptotic, anti-inflammatory and neuroprotective activities. In this study ...we investigated the effects of IMM-HOO4 on spatial memory in rats treated with okadaic acid （OKA）, which was used to imitate Alzheimer＇s disease （AD）-Iike symptoms. Methods： SD rats were administered IMM-HOO4 （8 mg.kg-1d-1, ig） or donepezil （positive control, 1mg.kg-1.d-1, ig） for 25 d. On d 8 and 9, OKA （200 ng） was microinjected into the right ventricle. Morris water maze test was used to evaluate the spatial memory impairments. Tau and 13-amyloid （Aβ） pathology in the hippocampus was detected using Western blot and immunohistochemistry. TUNEL staining was used to detect cell apoptosis. Results： OKA-treated rats showed significant impairments of spatial memory in Morris water maze test, which were largely reversed by administration of IMM-HO04 or donepezil. Furthermore, OKA-treated rats exhibited significantly increased phosphorylation of tau, deposits of Aβ protein and cell apoptosis in the hippocampus, which were also reversed by administration of IMM-HOO4 or donepezil. Conclusion： Administration of IMM-HO04 or donepezil protects rats against OKA-induced spatial memory impairments via attenuating tau or Aβ pathology. Thus, IMM-HOO4 may be developed as a therapeutic agent for the treatment of AD.
Hypotheses concerning the origins of modern humans have been intensively debated, and two competing models, the recent ＂Out-of-Africa＂ and ＂Multiregional Evolution＂ paradigms, have dominated research ...and discussions for decades. Evidence from China has played a fundamental role in this debate： regional continuity and replacement by populations in-migrated from Africa have both been suggested and supported mainly by paleoanthropologists and geneticists, respectively. As more evidence has accumulated, new results obtained, and more scholars from various disciplines become involved, supporters of the recent ＂Out-of-Africa＂ model agree more or less with the ＂Multiregional Evolution＂ model regarding the complex history of modern humans and their interbreeding with other archaic populations（e.g., Neandertals）. Recent discoveries of new human fossils, Paleolithic archaeological materials, and ancient DNA evidence in China have yielded a large body of information regarding the formation and development of modern humans in this region. However, controversies continue, including that most molecular biologists insist on the replacement of archaic populations by modern humans dispersed from Africa, while most paleoanthropologists and archaeologists propose an enhanced ＂Continuity with Hybridization＂ model. In this paper, we compile new results and progress in China and present the current debates and issues on the origins of modern humans. Finally, we offer several suggestions for future studies.
Structure stability analysis of rock masses is essential for forecasting catastrophic structure failure in coal seam mining. Steeply dipping thick coal seams （SDTCS） are common in the Urumqi ...coalfield, and some dynamical hazards such as roof collapse and mining-induced seismicity occur frequently in the coal mines. The cause of these events is mainly structure instability in giant rock pillars sand- wiched between SDTCS. Developing methods to predict these events is important for safe mining in such a complex environment. This study focuses on understanding the structural mechanics model of a giant rock pillar and presents a viewpoint of the stability of a trend sphenoid fractured beam （TSFB）. Some stability index parameters such as failure surface dips were measured, and most dips were observed to be between 46° and 51°. We used a digital panoramic borehole monitoring system to measure the TSFB＇s height （△H）, which varied from 56.37 to 60.50 m. Next, FLAC^3D was used to model the distribution and evolution of vertical displacement in the giant rock pillars; the results confirmed the existence of a TSFB structure. Finally, we investigated the acoustic emission （AE） energy accumulation rate and observed that the rate commonly ranged from 20 to 40 kJ/min. The AE energy accumulation rate could be used to anticipate impeding seismic events related to structure failure. The results presented provide a useful approach for forecasting catastrophic events related to structure instability and for developing hazard prevention technology for mining in SDTCS.
A numerical simulation study was performed to clarify the thermal mixing characteristics of coolant in the core bottom structure of the high-temperature gas-cooled reactor （HTR）. The flow field and ...temperature field in the hot gas chamber and the hot gas duct of the HTR were obtained based on the commercial computational fluid dynamics （CFD） program. The numerical simulation results showed that the helium flow with different tem- peratures in the hot gas mixing chamber and the hot gas duct mixed intensively, and the mixing rate of the tem- perature in the outlet of the hot gas duct reached 98 %. The results indicated many large-scale swirling flow structures and strong turbulence in the hot gas mixing chamber and the entrance of the hot gas duct, which were responsible for the excellent thermal mixing of the hot gas chamber and the hot gas duct. The calculated results showed that the temperature mixing rate of the hot gas chamber decreased only marginally with increasing Reynolds number.
Objective Conflicting data have been generated from previous studies to determine which kind of relationship exists between HIV-1 specific CD8 Tcell responses and HIV-1 viral load or CD4 count over ...the course of infection.In this study,153 HIV-1 infected LTNPs were enrolled to investigate the role of HIV-1 specific CD8 T-cell responses in chronic HIV-1 infection among HIV-1 infected former blood donors.Methods The patients were stratified into three groups according to CD4 count：CD4≥500 cells/μL;350 cells/μL≤CD4〈500 cells/μL;CD4〈350 cells/μL.PBMCs were isolated from the patients＇ anticoagulated blood samples.IL-2 and IFN-γ secretions of CD 8 T cells against 17 HIV-1 consensus B full peptide pools were analyzed by using ICS assay.Results An overall inverse correlation were observed between CD4 count and plasma viral load.Although no significant difference was observed during the comparisons of frequency/breadth of HIV-1 specific CD8 T cell responses,CD4 count stratification analysis showed that different correlation pattern existed in three strata：as for patients whose CD4 counts were less than 350 cells/μL,no significant correlations were identified between frequency/breadth of HIV-1 specific CD8 T cell responses and CD4 count/viral load;as for patients whose CD4 counts ranged from 350 cells /μL to 500 cells/μL,significant correlation was only observed between the response breadth of IL-2＋IFN-γ＋ CD8 T cells and CD4 count;however,as for patients whose CD4 counts were more than 500 cells/μL,direct correlations were identified between IL-2＋IFN-γ＋/IL-2＋/IFN-γ＋ CD8 T cells and viral load or CD4 count.Conclusions Universal consistent inverse correlation was only indentified between CD4 count and viral load.The relationship between HIV-1 specific CD8 T cell responses and CD4 count/viral load varied in different CD4 strata,which showed that better preserved CD4 T cells were correlated with better CD8 T cell functions.
Pilomyxoid Astrocytoma in Cerebellum Ge, Peng-fei; Wang, Hai-feng; Qu, Li-mei ...
Chinese Journal of Cancer Research/Chinese journal of cancer research,
09/2011, Volume:
23, Issue:
3
Journal Article
Peer reviewed
Open access
Pilomyxoid astrocytoma is a new identified variant type of pilocytic astrocytoma,and typically locates in the hypothalamic and chiasmatic region.Herein,we reported a nine-year-old boy with pilomyxoid ...astrocytoma in the cerebellum.MRI scanning showed a tumor involved the cerebellar vermis,tonsil,the forth ventricle and brainstem.It was homogeneous isointensity on T1WI,relative hyper-intensity on T2WI,hyper-intensity on fluid attenuated inversion recovery （FLAIR） images,and uniform enhancement on contrast T1WI.The tumor was sub-totally removed and was proved histologically to be pilomyxoid astrocytoma.Follow-up at the 5th month,MRI showed the residual tumor enlarged at the brainstem.The patient survived 10 months after the operation,and finally died of respiration failure resulting from brainstem dysfunction.
A series of novel anthranilic diamides analogues containing benzobthiophenyl ring was designed and synthesized. Their structures were characterized by melting points, 1H nuclear magnetic resonance（IH ...NMR） and high-resolution mass spectrometry（HRMS）. The bioassay tests indicate that their insecticidal activities were weak to moderate. Antibacterial tests indicate that some of the compounds showed favourable activity in vitro against Physa- lospora piricola, Alternaria solani, Cercospora arachidicola, Gibberella sanbinetti and Phytophthora infestans at a dosage of 50 mg/L.
The major storage substance in rice endosperm is starch, which accounts for 80% of dry matter weight. In this study, rice mutant flo7, selected from the progeny of Nipponbare＇s tissue culture, ...displayed floury and opaque endosperm. Compared with its corresponding wild type （WT） Nipponbare, the mutant rio7 produced longer, narrower, thinner and lighter grains. The levels of glucose, fructose and sucrose in the mutant flo7 endosperm were higher than those in the WT endosperm, whereas the protein content was not affected. With respect to both amylose content and gel consistency, the mutant flo7 was lower than WT, but its alkali value was higher. Scanning electron microscopic examinations showed that the endosperm of the mutant flo7 contained irregular, loosely packed and compound starch granules. Genetic analysis indicated that the mutant phenotype was determined by a single recessive nuclear gene The flo7 locus was mapped to a region on the long arm of chromosome 12, within a 95.1 kb interval defined by the markers C2-11 and C5-15. There are 13 open reading frames in the mapping interval. Transcription profiling of the developing grains showed that a number of genes involved in starch synthesis were affected differently in the mutant flo7.
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